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Here's the paper: https://nutrition.bmj.com/content/bmjnph/early/2021/01/07/bmjnph-2020-000151.full.pdf https://nutrition.bmj.com/content/bmjnph/early/2021/01/0

Here's the paper: https://nutrition.bmj.com/content/bmjnph/early/2021/01/07/bmjnph-2020-000151.full.pdf https://nutrition.bmj.com/content/bmjnph/early/2021/01/07/bm... Essentially, they appear to have used stratification on genetic factors to reduce potential confounders and improve their ability to get a less biased estimate. This seems reasonably solid to me, from a brief overview of the methods section (I'm not an expert though, so there may be flaws I missed). Definitely some countervailing evidence against Vit-D being directly related. There's almost certainly some third factor between Vit-D and health, but we don't yet have a good sense for what that might be. Note that the study is only analysing data for White British individuals, so if you are of a different ethnicity there may still be hope for you ;)

tomjen3 6y ago
>There's almost certainly some third factor between Vit-D and health A healthy balanced diet and (outdoor) life/exercise? Regardless it seems that a lack of vitamin D is bad for you, so even if it doesn't directly help with Covid taking suplements seems a nobrainer to me.
- disgruntledphd2 6y ago
  Yeah, that's my prior. Rather difficult to measure and put into an RCT though, unfortunately.
aeternum 6y ago
Seems flawed to me. When the individuals with genetic factors that make them Vit-D deficient go to the doctor, they will almost certainly be told to take Vit-D supplements at a higher rate than those without the genetic factor. This confounds the results and makes this type of study useless as it does not measure actual vitamin-D levels.