4 ms·

Yes, dosage should be 10k IU / day for starters with 5mg vitamin K2. Fat-soluble so take with a meal. Vitamin D depletes Vitamin A and magnesium, get the forme

Yes, dosage should be 10k IU / day for starters with 5mg vitamin K2. Fat-soluble so take with a meal. Vitamin D depletes Vitamin A and magnesium, get the former from foods and supplement the latter as magnesium glycinate and/or chloride. Other common & relevant deficiencies are boron and zinc, especially zinc.

mrob 6y ago
10k IU/day exceeds the Tolerable Upper Intake as determined by the US's National Academy of Medicine, the European Food Safety Authority, and similar organizations. Medical doctor Deva Boone posted a report of toxicity at half that dose: https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-story?postId=5f39453f8d01fe00170023fe https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st... This post and related posts about vitamin D were discussed on HN. See: https://news.ycombinator.com/from?site=devaboone.com https://news.ycombinator.com/from?site=devaboone.com
- lambdaba 6y ago
  I know, but that's in error: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/#:~:text=A%20statistical%20error%20in%20the,values%20%E2%89%A550%20nmol%2FL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/#:~:tex.... Doctors correcting vitamin D levels are finding 10k IU is a good starter dose and that is often insufficient to arrive at optimal levels.
  - mrob 6y ago
    Here's another report of toxicity at a similar dose: https://jeffchen.dev/posts/Vitamin-D-And-Heart-Palpitations/ https://jeffchen.dev/posts/Vitamin-D-And-Heart-Palpitations/ Dr Boone posted on HN, and claimed that vitamin K2 would not counteract high dose vitamin D: https://news.ycombinator.com/item?id=24262492 https://news.ycombinator.com/item?id=24262492 I am not aware of any randomized controlled trial of vitamin K2 for protection against vitamin D toxicity.
  - nradov 6y ago
    Really the only way to know the correct dose for any individual is to conduct occasional blood tests and dynamically adjust up or down. There as so many factors including diet, body composition, sunlight exposure, genetics, etc. One individual might need a daily dose several times higher than another.
- lambdaba 6y ago
  In your article the person was taking this dose for 5 years, and probably without vitamin k2 and developed hypercalcemia.

mrob 6y ago

10k IU/day exceeds the Tolerable Upper Intake as determined by the US's National Academy of Medicine, the European Food Safety Authority, and similar organizations. Medical doctor Deva Boone posted a report of toxicity at half that dose: https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-story?postId=5f39453f8d01fe00170023fe https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st... This post and related posts about vitamin D were discussed on HN. See: https://news.ycombinator.com/from?site=devaboone.com https://news.ycombinator.com/from?site=devaboone.com

lambdaba 6y ago
I know, but that's in error: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/#:~:text=A%20statistical%20error%20in%20the,values%20%E2%89%A550%20nmol%2FL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/#:~:tex.... Doctors correcting vitamin D levels are finding 10k IU is a good starter dose and that is often insufficient to arrive at optimal levels.
- mrob 6y ago
  Here's another report of toxicity at a similar dose: https://jeffchen.dev/posts/Vitamin-D-And-Heart-Palpitations/ https://jeffchen.dev/posts/Vitamin-D-And-Heart-Palpitations/ Dr Boone posted on HN, and claimed that vitamin K2 would not counteract high dose vitamin D: https://news.ycombinator.com/item?id=24262492 https://news.ycombinator.com/item?id=24262492 I am not aware of any randomized controlled trial of vitamin K2 for protection against vitamin D toxicity.
- nradov 6y ago
  Really the only way to know the correct dose for any individual is to conduct occasional blood tests and dynamically adjust up or down. There as so many factors including diet, body composition, sunlight exposure, genetics, etc. One individual might need a daily dose several times higher than another.
lambdaba 6y ago
In your article the person was taking this dose for 5 years, and probably without vitamin k2 and developed hypercalcemia.