9 ms·

Covid-19 Changes Our Sleep

59 points by prostoalex 6y ago

TameAntelope 6y ago
The amount we still don't know about the long term effects of being infected with COVID-19 is terrifying, and I honestly don't think it's talked about enough, because we have learned more. I recall another submission on HN yesterday, talking about how the brain puts on "brakes" to cognitive capacity in response to some viruses/injuries (the article itself was about reversing that cognitive decline) [0]. I wonder if some of the neurological effects of COVID-19 are related to that or something different entirely. [0] https://www.ucsf.edu/news/2020/12/419201/drug-reverses-age-related-mental-decline-within-days https://www.ucsf.edu/news/2020/12/419201/drug-reverses-age-r...
- JohnTHaller 6y ago
  My (lack of) sense of smell agrees with you. 9 months post infection.
  - andi999 6y ago
    Did you get a checkup? I had loss of sense of smell 4 years ago, some bacterial infection of paranasal sinus, treated with antibiotics. What I mean, maybe initially you lost it due to Corona, but some bacterial superinfection keeps it away.
  - Jon_Lowtek 6y ago
    covid based loss of smell is suspected to be a result of an infection of the sustentacular and basal cells in the olfactory epithelium. It should return once the infection is gone. You should probably have that checked out.
    - JohnTHaller 6y ago
      Some of it returned, but a bit messed up. Same with my girlfriend. Same with several friends. It's pretty common. I only regained the ability to smell natural gas somewhat in the last month. It varies day to day whether I can smell it, though. Or smell at all.
- standardUser 6y ago
  "The amount we still don't know about the long term effects of being infected with COVID-19 is terrifying" The amount that we do know about the potential long term effects of various other illnesses, including some that most of us have already had in our lifetimes, is also terrifying. Let's not forget that many illnesses can, in some percentage of cases, cause serious and ongoing problems. COVID-19 doesn't appear to be bizarrely unique in this respect, it's just new and receiving a uniquely massive amount of attention (obviously for good reason).
  - skulk 6y ago
    > COVID-19 doesn't appear to be bizarrely unique in this respect I don't agree. How many highly contagious, long-incubation, temporarily debilitating, and permanently damaging (cardiovascular, neurological, etc) diseases do we deal with regularly that we aren't already vaccinated against/haven't mostly eradicated? I haven't been alive long enough to remember tuberculosis, so this is quite bizarrely unique to me.
    - Izkata 6y ago
      > I haven't been alive long enough to remember tuberculosis, so this is quite bizarrely unique to me. You're alive right now, aren't you? From wikipedia (https://en.wikipedia.org/wiki/Tuberculosis https://en.wikipedia.org/wiki/Tuberculosis): > In 2018, there were more than 10 million cases of active TB which resulted in 1.5 million deaths.[7] This makes it the number one cause of death from an infectious disease.[13] [..] About 80% of people in many Asian and African countries test positive while 5–10% of people in the United States population test positive by the tuberculin test.[14] Mentions of tuberculosis stick out for me because there was a scare in my middle school that resulted in lots of us getting tested for it (in 2003, in the US). Luckily it was only a scare, as far as I'm aware none of the tests came out positive (and I know mine didn't).
    - standardUser 6y ago
      Influenza can cause all kinds of serious and long term health problems. So can most STDs any given bacterial infection if they are left unobserved/untreated for long enough. Most pathogens have some chance of causing serious problems, they are just usually rare, just like with COVID-19.
- vram22 6y ago
  > The amount we still don't know about the long term effects of being infected with COVID-19 is terrifying, and I honestly don't think it's talked about enough, because we have learned more. Maybe a dumb question, or maybe I did not understand (the part before the "and"), but how can one be terrified of what one does not know about? I agree with the part after the "and".
  - TameAntelope 6y ago
    https://markmanson.net/the-fear-of-the-unknown https://markmanson.net/the-fear-of-the-unknown Not everyone likes Mark, but if you’re curious, he explains the psychological situation better, at least, than I can.
    - vram22 6y ago
      Will check that out, thanks.
    - vram22 6y ago
      >Not everyone likes Mark Even after a brief look at his site, I can see why :) Didn't put me off, though. A guy who can read @dhh and @gnat can read Mark. Plus, I can see it is for effect.
- moistly 6y ago
  > the brain puts on "brakes" to cognitive capacity in response to some viruses/injuries A terrifying prospect. Misuse of lead (pipes, paint, gas) was a national tragedy with demonstrable ill effect on society and, IMO, still badly affecting the mental health of the older folk who grew up in that era. We can’t afford to take on another generation of mentally diminished, emotionally fragile citizens.
just-juan-post 6y ago
'Brain fog' following COVID-19 recovery may indicate PTSD https://www.uclahealth.org/brain-fog-following-covid-19-recovery-may-indicate-ptsd https://www.uclahealth.org/brain-fog-following-covid-19-reco...
DoofusOfDeath 6y ago
I'll be curious if those countries that minimized infections will be more competitive over the next few decades because of a population with less mental impairment.
- slig 6y ago
  Next decades? See the growth of China in 2020 with less than 100k infections and 5k deaths.
  - whatthesmack 6y ago
    > with less than 100k infections and 5k deaths Acceptance of this statement requires trusting the output of the CCP, which is inherently dishonest with these sort of metrics for political purposes.
zaroth 6y ago
The body of TFA rightly points out that we don’t actually have evidence that COVID directly causes problems with sleep. What we know is that since COVID and lockdowns, the number of people reporting sleep issues and seeking treatment for insomnia is increased. This is obviously entirely unsurprising. I think the more important point, somewhat ironically made on HN, is the critical effects of sleeplessness and promoting healthy sleep as a national public health priority. It seems to me this is just another pernicious example of how lockdowns and disrupting a population’s routines directly and indirectly damages public health.
- simonbarker87 6y ago
  My sleep was a mess over the summer and into mid autumn. I’ve only just reliably started sleeping through the night again. It’s always taken me a long time to get to sleep but from early May it was taking me a long time AND I was waking up two or three time’s a night which I’ve never had. Was horrible and I assumed a result of lock down and furlough.
- jacquesm 6y ago
  I can't believe that 11 months in and 1.7 million confirmed people dead, 350K of those your countrymen and I don't know how many people gravely ill and or affected for life that you are still on the 'let's downplay COVID-19' bandwagon. Didn't you learn anything at all in the last 11 months? I recall you categorically dismissing it and claiming that it was going to all be over in a couple of months. Here we are, almost a year later, the worst is yet to come - in spite of a vaccine, the roll-out is obviously not going to be instantaneous - and still you're harping away in every COVID-19 related thread minimizing whatever is written. It really is astounding.
  - Izkata 6y ago
    > Didn't you learn anything at all in the last 11 months? What I've learned over the past 11 months, from watching the numbers wax and wane with the seasons totally unrelated to the severity of lockdowns, the ages of those most affected (and for that matter asymptomatic estimates and the corrected IFR estimates), and the knock-on effects of the lockdowns? While it was good to be cautious initially, turns out for this particular virus we've blown it way out of proportion and ought to be letting up a lot more than we have been.
srameshc 6y ago
> The virus could potentially be blocked by melatonin. I was sleeping an average of 4-5 hours maximum a night. Once in a while I slept 7 hours, that was the maximum I could and I felt really great about it. Then I accidentally started intermittent fasting about 6 months back to see if helps with lowering cholesterol. But surprisingly I started sleeping more. Now, I eat my meals between 6am and 1pm. After that I fast. I sleep well and I can feel my body producing enough melatonin. For some reason, melatonin supplements never helped me when I tried before. My urge to drink alcohol has also lowered since even though I am an occasional drinker and I sleep for at least 8 hours a day. I can feel my body healing from at least 10 years of insomnia.
- martindbp 6y ago
  Aren't you hungry when going to bed?
  - srameshc 6y ago
    Sometimes when I eat light during the day, I feel intense hunger, happened more during early days. But even that hungry feeling wades off in about 45 minutes.
  - deleted 6y ago
    [deleted]
  - xboxnolifes 6y ago
    I view hunger almost like an addiction or a strong habit. If you eat 3 meals a day at 8am, 1pm, and 6pm, then you will feel hungry around those times every day. If you change your eating habits to eat only between 10am and 3pm, then you go through a period (of around a few days to a week) where you continue to feel hungry around 8am and 6pm or later, but your body adjusts to the new schedule. At least, that's how my body adjusts when I go between phases of eating breakfast and not easting breakfast.
    - leetcrew 6y ago
      the best diet "hack" I have found is simply not to keep any food in your home that can be ready to eat in less than ten minutes. that little bit of delay/work between feeling hungry and eating enables a much more intentional attitude towards eating for me. it's helped me realize that hunger signals don't necessarily mean my body actually needs nutrients at that instant. random feelings of hunger will often pass if I don't act on them.
wtk 6y ago
It makes sense to me. I had a pretty tough time going through Covid - bear in mind I really took care of my vit D intake, sun exposure and healthy food, exercise in months before. One thing I always lack is probably sleep. And then - living with my gf (she must have had it from me, can't imagine she wouldn't catch it) who had no signs of covid, with one thing she always get plenty of - sleep.
blck 6y ago
I was sick in February. At the time covid tests weren't as readily available to be tested but I had many of the symptoms of covid including debilitating headaches like I've never had before. Eventually I recover and test positive for antibodies. To this day I have issues sleeping and I'm not solely sure if it's anxiety due to pandemic or because of my presumptive case of covid. It's gotten slightly better in recent weeks but for months now I'd wake up about 30 minutes after falling asleep with a pounding heart and and feeling of extreme anxiety. Not as bad as a panic attack but still not pleasant.
- crazydoggers 6y ago
  This sounds a lot like sleep apnea symptoms. A sleep study would be well worth it. It may sound like a headache to go sleep in a lab, but if it is sleep apnea the positive life changes of treating it are beyond worth it. I used to wake with near panic attack just like that.... turns out I wasn’t breathing well. And you don’t have to be overweight to have sleep apnea. Since treating it, I sleep like a baby. Maybe covid induces some type of central sleep apnea?
  - glaugh 6y ago
    Barely related PSA: Just want to underline the “You don’t have to be overweight to have sleep apnea” thing. I, for example, have teeny tiny airway (via overbite) that gives me Obstructive Sleep Apnea. Took me, oh, 20 years to figure this out (Snoring is normalized/funny in our society but should be viewed as cause for potential concern) https://www.mayoclinic.org/diseases-conditions/snoring/symptoms-causes/syc-20377694 https://www.mayoclinic.org/diseases-conditions/snoring/sympt...
    - crazydoggers 6y ago
      Totally agree how snoring is normalized and probably shouldn’t be. I think there’s a lot of belief that sleep apnea is something that only happens to old or unhealthy individuals. Frankly for most people it’s due to airway size and back of throat muscle issues. Age and obesity simply bring it to the point where people are so sick they can’t ignore it, hence those who get treated. I tell people it’s more like needing glasses. Most people just are born with the issue that develops over time. We don’t have hang ups with treating vision problems (at least not anymore)... sleep apnea should be the same.
sradman 6y ago
The paper A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19 [1]: > We identified that melatonin usage (odds ratio [OR] = 0.72, 95% CI 0.56–0.91) is significantly associated with a 28% reduced likelihood of a positive laboratory test result for SARS-CoV-2 confirmed by reverse transcription–polymerase chain reaction assay. Using a PS matching user active comparator design, we determined that melatonin usage was associated with a reduced likelihood of SARS-CoV-2 positive test result compared to use of angiotensin II receptor blockers (OR = 0.70, 95% CI 0.54–0.92) or angiotensin-converting enzyme inhibitors (OR = 0.69, 95% CI 0.52–0.90). Importantly, melatonin usage (OR = 0.48, 95% CI 0.31–0.75) is associated with a 52% reduced likelihood of a positive laboratory test result for SARS-CoV-2 in African Americans after adjusting for age, sex, race, smoking history, and various disease comorbidities using PS matching. In summary, this study presents an integrative network medicine platform for predicting disease manifestations associated with COVID-19 and identifying melatonin for potential prevention and treatment of COVID-19. I'm not sure what to make of this. In my mind, melatonin usage is associated with sleep disorders just like ACE inhibitors are associated with cardiovascular disease (CVD), a known comorbidity. There are better ways to determine the impact of sleep on COVID-19 and vice versa. [1] https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000970 https://journals.plos.org/plosbiology/article?id=10.1371/jou...
- nradov 6y ago
  Melatonin is one of the nutritional supplements recommended in the Eastern Virginia Medical School COVID-19 care protocol. https://www.evms.edu/covid-19/covid_care_for_clinicians/#d.en.140202 https://www.evms.edu/covid-19/covid_care_for_clinicians/#d.e...
  - sradman 6y ago
    Is it based on any evidence besides this paper and its precursor [1]? [1] https://www.nature.com/articles/s41421-020-0153-3 https://www.nature.com/articles/s41421-020-0153-3
    - 6y ago
coding123 6y ago
Vitamin D and Vitamin A and anything else you've heard from a naturopath in the last 10 years to stop covid. And there's proof: > IgA antibodies were five times more effective than IgG antibodies at neutralizing SARS-CoV-2, the coronavirus that causes COVID-19. https://chrismasterjohnphd.com/covid-19/iga-antibodies-vitamin-a-and-covid-19 https://chrismasterjohnphd.com/covid-19/iga-antibodies-vitam... > Conclusion Greater proportion of vitamin D-deficient individuals with SARS-CoV-2 infection turned SARS-CoV-2 RNA negative with a significant decrease in fibrinogen on high-dose cholecalciferol supplementation. https://pmj.bmj.com/content/early/2020/11/12/postgradmedj-2020-139065 https://pmj.bmj.com/content/early/2020/11/12/postgradmedj-20...
deleted 6y ago
[deleted]
DataWorker 6y ago
Sleep and breathing are (obviously?) related.
williesleg 6y ago
I think covid changed all the sheeple to have shit for brains.
juancn 6y ago
WTF? How can you tell without explaining the mechanism? This is not a normal year by any measure of it. It's much more likely that the stress and change of habits caused by the pandemic response is causing the sleep patterns than the virus itself.

59 points by prostoalex 6y ago

The amount we still don't know about the long term effects of being infected with COVID-19 is terrifying, and I honestly don't think it's talked about enough, because we have learned more. I recall another submission on HN yesterday, talking about how the brain puts on "brakes" to cognitive capacity in response to some viruses/injuries (the article itself was about reversing that cognitive decline) [0]. I wonder if some of the neurological effects of COVID-19 are related to that or something different entirely. [0] https://www.ucsf.edu/news/2020/12/419201/drug-reverses-age-related-mental-decline-within-days https://www.ucsf.edu/news/2020/12/419201/drug-reverses-age-r...

JohnTHaller 6y ago
My (lack of) sense of smell agrees with you. 9 months post infection.
- andi999 6y ago
  Did you get a checkup? I had loss of sense of smell 4 years ago, some bacterial infection of paranasal sinus, treated with antibiotics. What I mean, maybe initially you lost it due to Corona, but some bacterial superinfection keeps it away.
- Jon_Lowtek 6y ago
  covid based loss of smell is suspected to be a result of an infection of the sustentacular and basal cells in the olfactory epithelium. It should return once the infection is gone. You should probably have that checked out.
  - JohnTHaller 6y ago
    Some of it returned, but a bit messed up. Same with my girlfriend. Same with several friends. It's pretty common. I only regained the ability to smell natural gas somewhat in the last month. It varies day to day whether I can smell it, though. Or smell at all.
standardUser 6y ago
"The amount we still don't know about the long term effects of being infected with COVID-19 is terrifying" The amount that we do know about the potential long term effects of various other illnesses, including some that most of us have already had in our lifetimes, is also terrifying. Let's not forget that many illnesses can, in some percentage of cases, cause serious and ongoing problems. COVID-19 doesn't appear to be bizarrely unique in this respect, it's just new and receiving a uniquely massive amount of attention (obviously for good reason).
- skulk 6y ago
  > COVID-19 doesn't appear to be bizarrely unique in this respect I don't agree. How many highly contagious, long-incubation, temporarily debilitating, and permanently damaging (cardiovascular, neurological, etc) diseases do we deal with regularly that we aren't already vaccinated against/haven't mostly eradicated? I haven't been alive long enough to remember tuberculosis, so this is quite bizarrely unique to me.
  - Izkata 6y ago
    > I haven't been alive long enough to remember tuberculosis, so this is quite bizarrely unique to me. You're alive right now, aren't you? From wikipedia (https://en.wikipedia.org/wiki/Tuberculosis https://en.wikipedia.org/wiki/Tuberculosis): > In 2018, there were more than 10 million cases of active TB which resulted in 1.5 million deaths.[7] This makes it the number one cause of death from an infectious disease.[13] [..] About 80% of people in many Asian and African countries test positive while 5–10% of people in the United States population test positive by the tuberculin test.[14] Mentions of tuberculosis stick out for me because there was a scare in my middle school that resulted in lots of us getting tested for it (in 2003, in the US). Luckily it was only a scare, as far as I'm aware none of the tests came out positive (and I know mine didn't).
  - standardUser 6y ago
    Influenza can cause all kinds of serious and long term health problems. So can most STDs any given bacterial infection if they are left unobserved/untreated for long enough. Most pathogens have some chance of causing serious problems, they are just usually rare, just like with COVID-19.
vram22 6y ago
> The amount we still don't know about the long term effects of being infected with COVID-19 is terrifying, and I honestly don't think it's talked about enough, because we have learned more. Maybe a dumb question, or maybe I did not understand (the part before the "and"), but how can one be terrified of what one does not know about? I agree with the part after the "and".
- TameAntelope 6y ago
  https://markmanson.net/the-fear-of-the-unknown https://markmanson.net/the-fear-of-the-unknown Not everyone likes Mark, but if you’re curious, he explains the psychological situation better, at least, than I can.
  - vram22 6y ago
    Will check that out, thanks.
  - vram22 6y ago
    >Not everyone likes Mark Even after a brief look at his site, I can see why :) Didn't put me off, though. A guy who can read @dhh and @gnat can read Mark. Plus, I can see it is for effect.
moistly 6y ago
> the brain puts on "brakes" to cognitive capacity in response to some viruses/injuries A terrifying prospect. Misuse of lead (pipes, paint, gas) was a national tragedy with demonstrable ill effect on society and, IMO, still badly affecting the mental health of the older folk who grew up in that era. We can’t afford to take on another generation of mentally diminished, emotionally fragile citizens.

just-juan-post 6y ago

'Brain fog' following COVID-19 recovery may indicate PTSD https://www.uclahealth.org/brain-fog-following-covid-19-recovery-may-indicate-ptsd https://www.uclahealth.org/brain-fog-following-covid-19-reco...

DoofusOfDeath 6y ago

I'll be curious if those countries that minimized infections will be more competitive over the next few decades because of a population with less mental impairment.

slig 6y ago
Next decades? See the growth of China in 2020 with less than 100k infections and 5k deaths.
- whatthesmack 6y ago
  > with less than 100k infections and 5k deaths Acceptance of this statement requires trusting the output of the CCP, which is inherently dishonest with these sort of metrics for political purposes.

zaroth 6y ago

The body of TFA rightly points out that we don’t actually have evidence that COVID directly causes problems with sleep. What we know is that since COVID and lockdowns, the number of people reporting sleep issues and seeking treatment for insomnia is increased. This is obviously entirely unsurprising. I think the more important point, somewhat ironically made on HN, is the critical effects of sleeplessness and promoting healthy sleep as a national public health priority. It seems to me this is just another pernicious example of how lockdowns and disrupting a population’s routines directly and indirectly damages public health.

simonbarker87 6y ago
My sleep was a mess over the summer and into mid autumn. I’ve only just reliably started sleeping through the night again. It’s always taken me a long time to get to sleep but from early May it was taking me a long time AND I was waking up two or three time’s a night which I’ve never had. Was horrible and I assumed a result of lock down and furlough.
jacquesm 6y ago
I can't believe that 11 months in and 1.7 million confirmed people dead, 350K of those your countrymen and I don't know how many people gravely ill and or affected for life that you are still on the 'let's downplay COVID-19' bandwagon. Didn't you learn anything at all in the last 11 months? I recall you categorically dismissing it and claiming that it was going to all be over in a couple of months. Here we are, almost a year later, the worst is yet to come - in spite of a vaccine, the roll-out is obviously not going to be instantaneous - and still you're harping away in every COVID-19 related thread minimizing whatever is written. It really is astounding.
- Izkata 6y ago
  > Didn't you learn anything at all in the last 11 months? What I've learned over the past 11 months, from watching the numbers wax and wane with the seasons totally unrelated to the severity of lockdowns, the ages of those most affected (and for that matter asymptomatic estimates and the corrected IFR estimates), and the knock-on effects of the lockdowns? While it was good to be cautious initially, turns out for this particular virus we've blown it way out of proportion and ought to be letting up a lot more than we have been.

srameshc 6y ago

> The virus could potentially be blocked by melatonin. I was sleeping an average of 4-5 hours maximum a night. Once in a while I slept 7 hours, that was the maximum I could and I felt really great about it. Then I accidentally started intermittent fasting about 6 months back to see if helps with lowering cholesterol. But surprisingly I started sleeping more. Now, I eat my meals between 6am and 1pm. After that I fast. I sleep well and I can feel my body producing enough melatonin. For some reason, melatonin supplements never helped me when I tried before. My urge to drink alcohol has also lowered since even though I am an occasional drinker and I sleep for at least 8 hours a day. I can feel my body healing from at least 10 years of insomnia.

martindbp 6y ago
Aren't you hungry when going to bed?
- srameshc 6y ago
  Sometimes when I eat light during the day, I feel intense hunger, happened more during early days. But even that hungry feeling wades off in about 45 minutes.
- deleted 6y ago
  [deleted]
- xboxnolifes 6y ago
  I view hunger almost like an addiction or a strong habit. If you eat 3 meals a day at 8am, 1pm, and 6pm, then you will feel hungry around those times every day. If you change your eating habits to eat only between 10am and 3pm, then you go through a period (of around a few days to a week) where you continue to feel hungry around 8am and 6pm or later, but your body adjusts to the new schedule. At least, that's how my body adjusts when I go between phases of eating breakfast and not easting breakfast.
  - leetcrew 6y ago
    the best diet "hack" I have found is simply not to keep any food in your home that can be ready to eat in less than ten minutes. that little bit of delay/work between feeling hungry and eating enables a much more intentional attitude towards eating for me. it's helped me realize that hunger signals don't necessarily mean my body actually needs nutrients at that instant. random feelings of hunger will often pass if I don't act on them.

wtk 6y ago

It makes sense to me. I had a pretty tough time going through Covid - bear in mind I really took care of my vit D intake, sun exposure and healthy food, exercise in months before. One thing I always lack is probably sleep. And then - living with my gf (she must have had it from me, can't imagine she wouldn't catch it) who had no signs of covid, with one thing she always get plenty of - sleep.

blck 6y ago

I was sick in February. At the time covid tests weren't as readily available to be tested but I had many of the symptoms of covid including debilitating headaches like I've never had before. Eventually I recover and test positive for antibodies. To this day I have issues sleeping and I'm not solely sure if it's anxiety due to pandemic or because of my presumptive case of covid. It's gotten slightly better in recent weeks but for months now I'd wake up about 30 minutes after falling asleep with a pounding heart and and feeling of extreme anxiety. Not as bad as a panic attack but still not pleasant.

crazydoggers 6y ago
This sounds a lot like sleep apnea symptoms. A sleep study would be well worth it. It may sound like a headache to go sleep in a lab, but if it is sleep apnea the positive life changes of treating it are beyond worth it. I used to wake with near panic attack just like that.... turns out I wasn’t breathing well. And you don’t have to be overweight to have sleep apnea. Since treating it, I sleep like a baby. Maybe covid induces some type of central sleep apnea?
- glaugh 6y ago
  Barely related PSA: Just want to underline the “You don’t have to be overweight to have sleep apnea” thing. I, for example, have teeny tiny airway (via overbite) that gives me Obstructive Sleep Apnea. Took me, oh, 20 years to figure this out (Snoring is normalized/funny in our society but should be viewed as cause for potential concern) https://www.mayoclinic.org/diseases-conditions/snoring/symptoms-causes/syc-20377694 https://www.mayoclinic.org/diseases-conditions/snoring/sympt...
  - crazydoggers 6y ago
    Totally agree how snoring is normalized and probably shouldn’t be. I think there’s a lot of belief that sleep apnea is something that only happens to old or unhealthy individuals. Frankly for most people it’s due to airway size and back of throat muscle issues. Age and obesity simply bring it to the point where people are so sick they can’t ignore it, hence those who get treated. I tell people it’s more like needing glasses. Most people just are born with the issue that develops over time. We don’t have hang ups with treating vision problems (at least not anymore)... sleep apnea should be the same.

sradman 6y ago

The paper A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19 [1]: > We identified that melatonin usage (odds ratio [OR] = 0.72, 95% CI 0.56–0.91) is significantly associated with a 28% reduced likelihood of a positive laboratory test result for SARS-CoV-2 confirmed by reverse transcription–polymerase chain reaction assay. Using a PS matching user active comparator design, we determined that melatonin usage was associated with a reduced likelihood of SARS-CoV-2 positive test result compared to use of angiotensin II receptor blockers (OR = 0.70, 95% CI 0.54–0.92) or angiotensin-converting enzyme inhibitors (OR = 0.69, 95% CI 0.52–0.90). Importantly, melatonin usage (OR = 0.48, 95% CI 0.31–0.75) is associated with a 52% reduced likelihood of a positive laboratory test result for SARS-CoV-2 in African Americans after adjusting for age, sex, race, smoking history, and various disease comorbidities using PS matching. In summary, this study presents an integrative network medicine platform for predicting disease manifestations associated with COVID-19 and identifying melatonin for potential prevention and treatment of COVID-19. I'm not sure what to make of this. In my mind, melatonin usage is associated with sleep disorders just like ACE inhibitors are associated with cardiovascular disease (CVD), a known comorbidity. There are better ways to determine the impact of sleep on COVID-19 and vice versa. [1] https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000970 https://journals.plos.org/plosbiology/article?id=10.1371/jou...

nradov 6y ago
Melatonin is one of the nutritional supplements recommended in the Eastern Virginia Medical School COVID-19 care protocol. https://www.evms.edu/covid-19/covid_care_for_clinicians/#d.en.140202 https://www.evms.edu/covid-19/covid_care_for_clinicians/#d.e...
- sradman 6y ago
  Is it based on any evidence besides this paper and its precursor [1]? [1] https://www.nature.com/articles/s41421-020-0153-3 https://www.nature.com/articles/s41421-020-0153-3
  - 6y ago

coding123 6y ago

Vitamin D and Vitamin A and anything else you've heard from a naturopath in the last 10 years to stop covid. And there's proof: > IgA antibodies were five times more effective than IgG antibodies at neutralizing SARS-CoV-2, the coronavirus that causes COVID-19. https://chrismasterjohnphd.com/covid-19/iga-antibodies-vitamin-a-and-covid-19 https://chrismasterjohnphd.com/covid-19/iga-antibodies-vitam... > Conclusion Greater proportion of vitamin D-deficient individuals with SARS-CoV-2 infection turned SARS-CoV-2 RNA negative with a significant decrease in fibrinogen on high-dose cholecalciferol supplementation. https://pmj.bmj.com/content/early/2020/11/12/postgradmedj-2020-139065 https://pmj.bmj.com/content/early/2020/11/12/postgradmedj-20...

deleted 6y ago

[deleted]

DataWorker 6y ago

Sleep and breathing are (obviously?) related.

williesleg 6y ago

I think covid changed all the sheeple to have shit for brains.

juancn 6y ago

WTF? How can you tell without explaining the mechanism? This is not a normal year by any measure of it. It's much more likely that the stress and change of habits caused by the pandemic response is causing the sleep patterns than the virus itself.