3 ms·
> Loperamide is not unique. I don't know why these researchers have singled it out. Probably because it's what they were studying which led to the analysis? A
by Supermancho 6y ago
> Loperamide is not unique. I don't know why these researchers have singled it out.
Probably because it's what they were studying which led to the analysis? A drug doesn't have to be unique to be important in understanding side effects...or off-label use if that's how you want to think of it.
Getting funding to study all of them at once is more challenging, so it shouldn't be a surprise that it's constrained to one.
- wittyreference 6y agoOpioids have already been studied regarding their neurotoxic effect. We already know they are neurotoxic. We already know they use the ATF4 pathway. Loperamide is an opioid. It's like a study finding that "opioid X" gets you high via mu-opioid receptors. It's not really a finding; it's the null hypothesis.
- Supermancho 6y ago> It's like a study finding that "opioid X" gets you high via mu-opioid receptors. It's not really a finding; it's the null hypothesis. More likely it's a liability check. The null hypothesis characterization is incidental.