3 ms·
Re getting loperamide in the bloodstream If a drug is metabolized in the liver then instead of ingesting a bottle of pills (most likely not safe, certainly not
by elmolino89 6y ago
Re getting loperamide in the bloodstream
If a drug is metabolized in the liver then instead of ingesting a bottle of pills (most likely not safe, certainly not recommended), the way to bypass the liver is to use suppositories.
Again, safety-wise it is not a sensible thing to do.
- Scoundreller 6y ago> the way to bypass the liver is to use suppositories Or transdermal or intranasal or sublingual or through the lungs or ... But I think the issue here is that the blood-brain barrier is actively pumping it back out, not immediate liver metabolism. I’ve updated my post a bit. I probably shouldn’t have said “locally” since it gets into the bloodstream and should have an effect from the other side too.
- elmolino89 6y ago0.3%. this is what according to Wikipedia you get in the bloodstream after the oral dose. Blood-brain barrier is another obstacle to cross. Quinidine taken with loperamide blocks transport protein P-glycoprotein and causing loperamide to have opioid like effects in the brain.