3 ms·

Some clinical work has been done with mRNA vaccines as treatments for other diseases, including cancer. Nothing has made it to Phase 3 yet (other than for Covid

by aazaa 6y ago

Some clinical work has been done with mRNA vaccines as treatments for other diseases, including cancer. Nothing has made it to Phase 3 yet (other than for Covid-19), but on this page you'll find links to a slew of clinical trials over the years. https://www.modernatx.com/pipeline/modernas-mrna-clinical-trials-cmv-mma-zika-several-types-cancer-and-other-diseases https://www.modernatx.com/pipeline/modernas-mrna-clinical-tr... A handful of studies are currently recruiting for Phase 2, so that means there was a successful Phase 1 some years ago. So those people would, I believe, be the longest-surviving patients to have received an mRNA vaccine.

Scoundreller 6y ago
The Phase 1 study might just mean it didn’t immediately harm the people that got it. They might be followed closely for a long time; but it may only be a handful of people too.
divbzero 6y ago
Yes, and also a number of non-Moderna clinical trials dating back to 2008. [1] The largest of those trials enrolled around 200 participants — not Phase 3 sized but still significant. [1]: https://www.nature.com/articles/nrd.2017.243/tables/2 https://www.nature.com/articles/nrd.2017.243/tables/2
dharma1 6y ago
Which companies besides Moderna are at/near phase 2 for vaccines against other diseases now?