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Quick question on Alphafold - is it a one time effort ? Like human genome sequencing. Like if we 3d map all the 170 million sequences (using alphafold or whate
by sandGorgon 6y ago
Quick question on Alphafold - is it a one time effort ? Like human genome sequencing.
Like if we 3d map all the 170 million sequences (using alphafold or whatever),we are done right ? We can just look up in the library.
New protein sequences don't continually get created ?
- jasoncrawford 6y agoWell, there's genetic engineering. We might want to create new proteins—enzymes for chemical reactions, for instance.
- cdirkx 6y agoFrom my understanding it was mostly useful for understanding new sequences in medical and genetic engineering; questions like can we modify this part of the protein and keep the overall structure the same.
- hobofan 6y ago> Like human genome sequencing Human genome sequencing was not a one time effort. The Human Genome Project was a one time push to establish the capabilities of human genome sequencing, but the field has seen a lot of refinement since then, to apply it both to individuals and to construct a better human reference genome. > New protein sequences don't continually get created? As others have said, there are new proteins being engineered by humans. Apart from that there are a lot of organisms that haven't been sequenced yet (not even counting niche organisms that haven't been discovered yet). Especially in the plant world, sequencing advancements with nanopore sequencing only recently made it economical (and possible) to sequence a lot of the plant genomes that are many times larger than the human one. So Alphafold might be comparable to the Human Genome Project in specific ways.