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Solving the inverse problem would be even more valuable -- given a specific shape (and other biochemical desiderata), what sequence of amino acids would create
by randcraw 6y ago
Solving the inverse problem would be even more valuable -- given a specific shape (and other biochemical desiderata), what sequence of amino acids would create that protein?
As hard as the protein folding problem is, the inverse problem is harder still. THAT is the one true grail.
- dekhn 6y agoWe "solved" this at Google years ago using Exacycle. We ran Rosetta (the premier protein design tool) at scale. The visiting scientist (who later joined GOogle and created DeepDream) said it worked really well "I could just watch a folder and good designs would show up as PDB files in a directory".