3 ms·

I guess other studies are perfect and survived this level of scrutiny. Especially the "recovery" one, praised by everybody where the inclusion criteria was: "h

by rq1 6y ago

I guess other studies are perfect and survived this level of scrutiny. Especially the "recovery" one, praised by everybody where the inclusion criteria was: "having flu like symptoms", without PCR. This is true science indeed. https://www.les-crises.fr/the-tremendous-ethical-and-methodological-flaws-in-the-raoult-clinical-trial-analysis-by-olivier-berruyer/#ancre7 https://www.les-crises.fr/the-tremendous-ethical-and-methodo... 1. Why is this a major flaw? 2. As stated by the title. Remark: (Well conducted) RCTs introduce way too much variance. As a statistician I care about a good trade-off between bias and variance. OTOH, you don't need RCTs when you measure a physical property of a system. 3-6,8. Valid points. Especially as of publication date. As of today, they updated the study with 3000+ patients. 7. This is not ethical. 9. Object of the study: measure viral load. After the cytokine storm, you don't care much about the virus. 10. We should ask DR directly about it, this is grave. 11-13. Irrelevant. They did PCRs to everyone, the important measure is the CT. 14. This is not good indeed. 15. PCR tests are reliable. 16. Why is it a flaw? 17-18. They published a lot of other papers on their work, and updated the early study.

orwin 6y ago
> As of today, they updated the study with 3000+ patients. Yes, this update was around July. They found an IFR of .7% with patient treated with HCQ. Lower than the 1.2% mortality rate in eastern France. But wait! In august, the IFR of eastern France was calculated again and was found to be around .7% (+-.3%) too? SO since august, the narrative changed: HCQ soes not prevent people from dying at all, but prevent them to carry a viral load important enough to contaminate other people as much. With no real study, as doing so would be unethical. Convenient. Honestly if you followed the story as much as i did (and i did buy HCQ early on, as my boss was a fan and sold me on Raoult with daily update), it became more and more ridiculous, with the organ point was the IFR recalculation in august, when i told myself i should be ashamed to have willingly believed something this early, coming from someone who, as Bergame started dying and Colmar was being infected, stated that the virus would not be coming to France, then, as my cousin bagged the 18th body in his hospital, posted a video called "Coronavirus: Game Over!", later edited and renamed.
- rq1 6y ago
  Mean value theorem hardly allows that :) Maybe I misinterpret what you’re saying, can you give me exactly the source for your numbers? Your last paragraph feels like you have personal grief against him.

by rq1 6y ago

orwin 6y ago

> As of today, they updated the study with 3000+ patients. Yes, this update was around July. They found an IFR of .7% with patient treated with HCQ. Lower than the 1.2% mortality rate in eastern France. But wait! In august, the IFR of eastern France was calculated again and was found to be around .7% (+-.3%) too? SO since august, the narrative changed: HCQ soes not prevent people from dying at all, but prevent them to carry a viral load important enough to contaminate other people as much. With no real study, as doing so would be unethical. Convenient. Honestly if you followed the story as much as i did (and i did buy HCQ early on, as my boss was a fan and sold me on Raoult with daily update), it became more and more ridiculous, with the organ point was the IFR recalculation in august, when i told myself i should be ashamed to have willingly believed something this early, coming from someone who, as Bergame started dying and Colmar was being infected, stated that the virus would not be coming to France, then, as my cousin bagged the 18th body in his hospital, posted a video called "Coronavirus: Game Over!", later edited and renamed.

rq1 6y ago
Mean value theorem hardly allows that :) Maybe I misinterpret what you’re saying, can you give me exactly the source for your numbers? Your last paragraph feels like you have personal grief against him.