4 ms·

I've noticed more health and aging related articles on this site. I wonder if its a sign the HN community is getting older. :)

deleted 6y ago
[deleted]
melling 6y ago
The site is almost 15 years old so it’s possible. People become a little more self-aware as they get older. First you know someone famous that died young from a horrible disease. Next you personally know someone who died from a disease. Then you get older and wonder if the “1 in 3 people” might be you.
- drran 6y ago
  I take anti-aging drugs for about 10 years. I heard about them at HN.
  - pmiller2 6y ago
    How has that worked out for you? What are you taking?
    - drran 6y ago
      I survived about ten attempts to assassinate me. Still alive. Quercetin and glycine. IMHO, they help to stay healthy and slow aging, but does not stop it. I also tried resveratrol and nicotinamide for a few months.
      - api 6y ago
        Is there good evidence for quercetin alone? I recall reading a bit about quercetin with other things (I think it was a chemo med at lower dose) as a senolytic but not quercetin alone.
  - api 6y ago
    What's in your stack bruh?
    - 1996 6y ago
      Metformin 1g twice a day MSM 3g + Vitamin C 1g + NAC 600mg thrice a day Kimchi (for Vitamin K) at breakfast, Niacinamide from a multivitamin B + Vitamin D 5kUI + Magnesium glycinate at night, with Melatonin 60 mg sublingual at night (20x the doses for sleeping is among other things anti-inflammatory and radioprotective) Every few months an azythromycin+doxycyclin+vitamin C cure as a senolytic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520007/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520007/ Every few month a dasatinib+quercetin cure as another senolytic : https://sci-hub.se/10.1146/annurev-pharmtox-050120-105018 https://sci-hub.se/10.1146/annurev-pharmtox-050120-105018 BTW dasatinib+quercetin are also in clinical trials NCT02848131 and NCT02874989
  - reducesuffering 6y ago
    Betting this is berberine or metformin?
- WalterBright 6y ago
  Outliving your parents is very perspective changing. Knowing people younger than you who die of old man's diseases. Your doctor is younger than you are. The President is younger than you are. Your longtime friends look old.
perardi 6y ago
Could be that “pandemic” thing making people a bit more cognizant of mortality.
- throwaway201103 6y ago
  The people dying of COVID are for the most part over age 70. Many are over 80. This is an age where death and disease are unremarkable.
  - flavor8 6y ago
    > for the most part over age 70. CDC categories don't line up to "70" that well, but there are plenty of younger deaths. 51% are 74 or younger. 33% are 64 or younger. https://data.cdc.gov/NCHS/Provisional-COVID-19-Death-Counts-by-Sex-Age-and-S/9bhg-hcku https://data.cdc.gov/NCHS/Provisional-COVID-19-Death-Counts-...
    - belval 6y ago
      I think you should check the very link you sent because only 21% are 64 or younger. The ranges overlap.
  - jjulius 6y ago
    That's not necessarily what OP's saying. My inference is that OP is suggesting that a constantly prevalent pandemic makes people more likely to think about their own health and mortality in a broader sense than they might if there weren't a pandemic.
- jolmg 6y ago
  I think the increase of popularity of these types of articles happened mostly before the pandemic.
ve55 6y ago
I think a lot of it is that we're just now starting to get to where we need to be as a civilization for anti-aging to start to become something that not only sounds feasible, but is feasible. I've noticed interest steadily increasing over the last 5 or so years, and think this will be a huge topic in the next few decades.
- grishka 6y ago
  The aging-related research has been going for quite some time, so it's not surprising it's starting to bear fruit, for now in the form of better understanding of the underlying mechanisms. The consensus seems to be shifting from "wear-and-tear model" to a series pre-programmed epigenetic alterations, which, to me at least as a layman, feels more plausible. There's a good chance we'll see some anti-aging treatments released within our lifetimes. We might end up being the first generation to have reached the longevity escape velocity. The reason it's only starting to emerge now is as far as I understand that molecular biology is a relatively new field, and the related technologies simply didn't exist not so long ago.

deleted 6y ago

[deleted]

melling 6y ago

The site is almost 15 years old so it’s possible. People become a little more self-aware as they get older. First you know someone famous that died young from a horrible disease. Next you personally know someone who died from a disease. Then you get older and wonder if the “1 in 3 people” might be you.

drran 6y ago
I take anti-aging drugs for about 10 years. I heard about them at HN.
- pmiller2 6y ago
  How has that worked out for you? What are you taking?
  - drran 6y ago
    I survived about ten attempts to assassinate me. Still alive. Quercetin and glycine. IMHO, they help to stay healthy and slow aging, but does not stop it. I also tried resveratrol and nicotinamide for a few months.
    - api 6y ago
      Is there good evidence for quercetin alone? I recall reading a bit about quercetin with other things (I think it was a chemo med at lower dose) as a senolytic but not quercetin alone.
- api 6y ago
  What's in your stack bruh?
  - 1996 6y ago
    Metformin 1g twice a day MSM 3g + Vitamin C 1g + NAC 600mg thrice a day Kimchi (for Vitamin K) at breakfast, Niacinamide from a multivitamin B + Vitamin D 5kUI + Magnesium glycinate at night, with Melatonin 60 mg sublingual at night (20x the doses for sleeping is among other things anti-inflammatory and radioprotective) Every few months an azythromycin+doxycyclin+vitamin C cure as a senolytic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520007/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520007/ Every few month a dasatinib+quercetin cure as another senolytic : https://sci-hub.se/10.1146/annurev-pharmtox-050120-105018 https://sci-hub.se/10.1146/annurev-pharmtox-050120-105018 BTW dasatinib+quercetin are also in clinical trials NCT02848131 and NCT02874989
- reducesuffering 6y ago
  Betting this is berberine or metformin?
WalterBright 6y ago
Outliving your parents is very perspective changing. Knowing people younger than you who die of old man's diseases. Your doctor is younger than you are. The President is younger than you are. Your longtime friends look old.

perardi 6y ago

Could be that “pandemic” thing making people a bit more cognizant of mortality.

throwaway201103 6y ago
The people dying of COVID are for the most part over age 70. Many are over 80. This is an age where death and disease are unremarkable.
- flavor8 6y ago
  > for the most part over age 70. CDC categories don't line up to "70" that well, but there are plenty of younger deaths. 51% are 74 or younger. 33% are 64 or younger. https://data.cdc.gov/NCHS/Provisional-COVID-19-Death-Counts-by-Sex-Age-and-S/9bhg-hcku https://data.cdc.gov/NCHS/Provisional-COVID-19-Death-Counts-...
  - belval 6y ago
    I think you should check the very link you sent because only 21% are 64 or younger. The ranges overlap.
- jjulius 6y ago
  That's not necessarily what OP's saying. My inference is that OP is suggesting that a constantly prevalent pandemic makes people more likely to think about their own health and mortality in a broader sense than they might if there weren't a pandemic.
jolmg 6y ago
I think the increase of popularity of these types of articles happened mostly before the pandemic.

ve55 6y ago

I think a lot of it is that we're just now starting to get to where we need to be as a civilization for anti-aging to start to become something that not only sounds feasible, but is feasible. I've noticed interest steadily increasing over the last 5 or so years, and think this will be a huge topic in the next few decades.

grishka 6y ago
The aging-related research has been going for quite some time, so it's not surprising it's starting to bear fruit, for now in the form of better understanding of the underlying mechanisms. The consensus seems to be shifting from "wear-and-tear model" to a series pre-programmed epigenetic alterations, which, to me at least as a layman, feels more plausible. There's a good chance we'll see some anti-aging treatments released within our lifetimes. We might end up being the first generation to have reached the longevity escape velocity. The reason it's only starting to emerge now is as far as I understand that molecular biology is a relatively new field, and the related technologies simply didn't exist not so long ago.