3 ms·
> MDMA can be neurotoxic if taken repeatedly and heavily I remember back in the days on a certain research chemicals subreddit where people were raving about t
by raducu 6y ago
> MDMA can be neurotoxic if taken repeatedly and heavily
I remember back in the days on a certain research chemicals subreddit where people were raving about the "borax combo" -- a mix of 4 or 5 substances that were indistinguishable from MDMA and had no crash like MDMA and the ingredients themselves were not known to be neurotoxic.
I think they just looked at the MDMA receptor affinity and just combined substances that would roughly match that receptor affinity.
Also as far as I know, MDMA is only neurotoxic because of it being processed by the liver and MDMA injected in pig or rat brain was not supposed to be neurotoxic.
- api 6y agoAFAIK the mechanism is serotonin depletion. Spaced doses of a sane amount is not neurotoxic, but if you take too much or worse take it very frequently serotonin can be depleted and... I forget the chemical mechanism, but bad things happen. I'm sure it's not hard to find with a search. The worst thing to do from what I've read is take more MDMA right after a dose wears off to try to prolong the high. That's where you get into neurotoxicity.
- pak9rabid 6y agoFrom what I understand, once serotonin is depleted enough in the synapse, the serotonin reuptake transporterss begin to bind to dopamine (instead of serotonin), and that by itself is toxic to that part of the neuron. To make matters worse, the neuron then converts the uptaken dopamine into hydrogen peroxide, which is VERY toxic to that part of the neuron (the axon terminal), which then causes it to fizzle away. I recall a way around that (other than by just not taking MDMA at all, obviously) is to take an SSRI (like Prozac) at some point after rolling, which would bind to the reuptake transporters, preventing dopamine from doing so.