4 ms·

Can you OD on vitamin D from getting too much sun? Or does your body have a way to turn off the production? Same question but say you take a high supplement a

Can you OD on vitamin D from getting too much sun? Or does your body have a way to turn off the production? Same question but say you take a high supplement and then have a day in the sun?

anonuser123456 6y ago
UV also photo-degrades subcutaneous vitamin B in the skin so you can't OD via sunlight. Exogenous UV not in the skin will not be photo-degraded, so supplement + sun may lead to overdose.
coding123 6y ago
In a way. If I take a lot of vitamin D in one day (like 10K UI) I typically get chills, sweats, nausea (sometimes even vomiting) and other fever like symptoms. I think it's the effect of your body turning on its fight against infection. I don't know if that's "OD"ing specifically. But I am replying because I get the exact same thing when I'm out in the sun all day long. I do feel like you probably can't get 130000 UIs from being in the sun in a single day.
- hammock 6y ago
  That's called sun poisoning and it's not related to Vitamin D.
  - Supermancho 6y ago
    I had not heard of sun poisoning, although I've suffered it. I've been told it was heatstroke (since no sunburn), but it felt different and indeed it is (due to medicines I take). Thanks for that tidbit.
    - phobosanomaly 6y ago
      So there's this thing called polymorphic light eruption (which is a stupid convoluted science word for sunburn): "The cause of polymorphic light eruption is unknown. It is postulated that there is a delayed hypersensitivity reaction to an endogenous antigen expressed after exposure to sunlight or artificial sources of ultraviolet (UV) radiation." Hypersensitivity means allergic reaction. UV radiation is murking your exposed skin cells because it causes such severe DNA damage that the cells commit suicide in a process called 'apoptosis.' The body's immune system is freaking out because it's seeing a bunch of stuff all of a sudden, that has floated out of your dead skin cells, that it isn't supposed to see. It releases a ton of chemicals that make you feel nauseous, crappy, and sore, and which normally are key parts of fighting infection as part of the inflammation reaction. Oakley AM, Ramsey ML. Polymorphic Light Eruption. [Updated 2020 Aug 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430886/ https://www.ncbi.nlm.nih.gov/books/NBK430886/ This results in: > "Release of inflammatory markers such as prostaglandins, reactive oxygen species, and bradykinin." > "This leads to vasodilation, edema, and pain which translates into the classically red, painful skin seen in a sunburn." > "Additionally, skin exposure to UVB causes an increase in chemokines such as CXCL5 and activates peripheral nociceptors, which results in over-activation of the pain receptors of the skin." Guerra KC, Urban K, Crane JS. Sunburn. [Updated 2020 Aug 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534837/ https://www.ncbi.nlm.nih.gov/books/NBK534837/ That allergic reaction is in addition to the common damage to the DNA of the skin cells caused by the UV radiation, that may occur before you get any of that pain and swelling. This is scary because if the cells are dead, ok you get a sunburn, but that's because they're dead. If the DNA is damaged and the cells don't die, you can lose genes like cell cycle checkpoint inhibitors and tumor suppressors. And BAM, melanoma which winds up killing somewhere in the ballpark of 9,000 people in the U.S. each year, as well as squamous cell carcinoma which kills like another 15,000. https://www.cdc.gov/cancer/uscs/about/data-briefs/no9-melanoma-incidence-mortality-UnitedStates-2012-2016.htm https://www.cdc.gov/cancer/uscs/about/data-briefs/no9-melano... https://www.skincancer.org/skin-cancer-information/skin-cancer-facts/#:~:text=The%20latest%20figures%20suggest%20that,nonmelanoma%20skin%20cancer%20every%20month https://www.skincancer.org/skin-cancer-information/skin-canc....
phobosanomaly 6y ago
Based on my understanding, the main problem surrounding too much Vitamin D is with high levels of calcium that develop. Vitamin D plays a big role as a calcium-regulatory hormone, and too much of it can lead to elevated levels of calcium in the blood. However, in a normal, healthy adult, the body's own feedback-inhibitory mechanisms will just downregulate synthesis of the hormone when too much calcium is detected in the blood. If you're sick or have other things going on (like cancer or taking too many Vitamin D tablets), however, it can be a problem: Papapetrou PD, Bergi-Stamatelou M, Karga H, Thanou S. Hypercalcemia due to sun exposure in a patient with multiple myeloma and elevated parathyroid hormone-related protein. Eur J Endocrinol. 2003 Mar;148(3):351-5. doi: 10.1530/eje.0.1480351. PMID: 12611617. https://pubmed.ncbi.nlm.nih.gov/12611617/ https://pubmed.ncbi.nlm.nih.gov/12611617/ Use of vitamin D drops leading to kidney failure in a 54-year-old man Bourne L. Auguste, Carmen Avila-Casado, Joanne M. Bargman CMAJ Apr 2019, 191 (14) E390-E394; DOI: 10.1503/cmaj.180465 https://www.cmaj.ca/content/191/14/E390 https://www.cmaj.ca/content/191/14/E390 Naik MA, Banday KA, Najar MS, Reshi AR, Bhat MA. Vitamin D intoxication presenting as acute renal failure. Indian J Nephrol. 2008;18(3):125-126. doi:10.4103/0971-4065.43693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813130/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813130/ "Hypercalcemia is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work." https://www.mayoclinic.org/diseases-conditions/hypercalcemia/symptoms-causes/syc-20355523#:~:text=Hypercalcemia%20is%20a%20condition%20in,result%20of%20overactive%20parathyroid%20glands https://www.mayoclinic.org/diseases-conditions/hypercalcemia.... Here's the graphic on Vitamin D synthesis in the body from Wikipedia, you can see that the enzyme CYP27B1 is inhibited by elevated levels of calcium in the blood, so calcidiol is shunted into production of an inactive metabolite. This is what would be happening if you were out sunbathing for 123123 hours per day. https://en.wikipedia.org/wiki/File:VitaminDSynthesis_WP1531.png https://en.wikipedia.org/wiki/File:VitaminDSynthesis_WP1531....
- _0ffh 6y ago
  Yes that's true, and it's the reason that K2 pops up every time D/D3 is discussed. K2 regulates the calcium flows in the body, so that it ends up where it should be (e.g. bones) and not where it should not be (e.g. soft tissue). I take ~40mcg of K2 M7 all-trans per 1000IU of D3.
IndySun 6y ago
Can you overdose on vit D from being in the sun? No. https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/ https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-...

Can you OD on vitamin D from getting too much sun? Or does your body have a way to turn off the production? Same question but say you take a high supplement and then have a day in the sun?

anonuser123456 6y ago

UV also photo-degrades subcutaneous vitamin B in the skin so you can't OD via sunlight. Exogenous UV not in the skin will not be photo-degraded, so supplement + sun may lead to overdose.

coding123 6y ago

In a way. If I take a lot of vitamin D in one day (like 10K UI) I typically get chills, sweats, nausea (sometimes even vomiting) and other fever like symptoms. I think it's the effect of your body turning on its fight against infection. I don't know if that's "OD"ing specifically. But I am replying because I get the exact same thing when I'm out in the sun all day long. I do feel like you probably can't get 130000 UIs from being in the sun in a single day.

hammock 6y ago
That's called sun poisoning and it's not related to Vitamin D.
- Supermancho 6y ago
  I had not heard of sun poisoning, although I've suffered it. I've been told it was heatstroke (since no sunburn), but it felt different and indeed it is (due to medicines I take). Thanks for that tidbit.
  - phobosanomaly 6y ago
    So there's this thing called polymorphic light eruption (which is a stupid convoluted science word for sunburn): "The cause of polymorphic light eruption is unknown. It is postulated that there is a delayed hypersensitivity reaction to an endogenous antigen expressed after exposure to sunlight or artificial sources of ultraviolet (UV) radiation." Hypersensitivity means allergic reaction. UV radiation is murking your exposed skin cells because it causes such severe DNA damage that the cells commit suicide in a process called 'apoptosis.' The body's immune system is freaking out because it's seeing a bunch of stuff all of a sudden, that has floated out of your dead skin cells, that it isn't supposed to see. It releases a ton of chemicals that make you feel nauseous, crappy, and sore, and which normally are key parts of fighting infection as part of the inflammation reaction. Oakley AM, Ramsey ML. Polymorphic Light Eruption. [Updated 2020 Aug 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430886/ https://www.ncbi.nlm.nih.gov/books/NBK430886/ This results in: > "Release of inflammatory markers such as prostaglandins, reactive oxygen species, and bradykinin." > "This leads to vasodilation, edema, and pain which translates into the classically red, painful skin seen in a sunburn." > "Additionally, skin exposure to UVB causes an increase in chemokines such as CXCL5 and activates peripheral nociceptors, which results in over-activation of the pain receptors of the skin." Guerra KC, Urban K, Crane JS. Sunburn. [Updated 2020 Aug 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534837/ https://www.ncbi.nlm.nih.gov/books/NBK534837/ That allergic reaction is in addition to the common damage to the DNA of the skin cells caused by the UV radiation, that may occur before you get any of that pain and swelling. This is scary because if the cells are dead, ok you get a sunburn, but that's because they're dead. If the DNA is damaged and the cells don't die, you can lose genes like cell cycle checkpoint inhibitors and tumor suppressors. And BAM, melanoma which winds up killing somewhere in the ballpark of 9,000 people in the U.S. each year, as well as squamous cell carcinoma which kills like another 15,000. https://www.cdc.gov/cancer/uscs/about/data-briefs/no9-melanoma-incidence-mortality-UnitedStates-2012-2016.htm https://www.cdc.gov/cancer/uscs/about/data-briefs/no9-melano... https://www.skincancer.org/skin-cancer-information/skin-cancer-facts/#:~:text=The%20latest%20figures%20suggest%20that,nonmelanoma%20skin%20cancer%20every%20month https://www.skincancer.org/skin-cancer-information/skin-canc....

phobosanomaly 6y ago

Based on my understanding, the main problem surrounding too much Vitamin D is with high levels of calcium that develop. Vitamin D plays a big role as a calcium-regulatory hormone, and too much of it can lead to elevated levels of calcium in the blood. However, in a normal, healthy adult, the body's own feedback-inhibitory mechanisms will just downregulate synthesis of the hormone when too much calcium is detected in the blood. If you're sick or have other things going on (like cancer or taking too many Vitamin D tablets), however, it can be a problem: Papapetrou PD, Bergi-Stamatelou M, Karga H, Thanou S. Hypercalcemia due to sun exposure in a patient with multiple myeloma and elevated parathyroid hormone-related protein. Eur J Endocrinol. 2003 Mar;148(3):351-5. doi: 10.1530/eje.0.1480351. PMID: 12611617. https://pubmed.ncbi.nlm.nih.gov/12611617/ https://pubmed.ncbi.nlm.nih.gov/12611617/ Use of vitamin D drops leading to kidney failure in a 54-year-old man Bourne L. Auguste, Carmen Avila-Casado, Joanne M. Bargman CMAJ Apr 2019, 191 (14) E390-E394; DOI: 10.1503/cmaj.180465 https://www.cmaj.ca/content/191/14/E390 https://www.cmaj.ca/content/191/14/E390 Naik MA, Banday KA, Najar MS, Reshi AR, Bhat MA. Vitamin D intoxication presenting as acute renal failure. Indian J Nephrol. 2008;18(3):125-126. doi:10.4103/0971-4065.43693 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813130/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813130/ "Hypercalcemia is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work." https://www.mayoclinic.org/diseases-conditions/hypercalcemia/symptoms-causes/syc-20355523#:~:text=Hypercalcemia%20is%20a%20condition%20in,result%20of%20overactive%20parathyroid%20glands https://www.mayoclinic.org/diseases-conditions/hypercalcemia.... Here's the graphic on Vitamin D synthesis in the body from Wikipedia, you can see that the enzyme CYP27B1 is inhibited by elevated levels of calcium in the blood, so calcidiol is shunted into production of an inactive metabolite. This is what would be happening if you were out sunbathing for 123123 hours per day. https://en.wikipedia.org/wiki/File:VitaminDSynthesis_WP1531.png https://en.wikipedia.org/wiki/File:VitaminDSynthesis_WP1531....

_0ffh 6y ago
Yes that's true, and it's the reason that K2 pops up every time D/D3 is discussed. K2 regulates the calcium flows in the body, so that it ends up where it should be (e.g. bones) and not where it should not be (e.g. soft tissue). I take ~40mcg of K2 M7 all-trans per 1000IU of D3.

IndySun 6y ago

Can you overdose on vit D from being in the sun? No. https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/ https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-...