You are right that Base2048 is tailor-made for Twitter, but I think so is Base65536. More specifically, the explicit length limitation is easily one of the wei

You are right that Base2048 is tailor-made for Twitter, but I think so is Base65536. More specifically, the explicit length limitation is easily one of the weirdest aspects of Twitter. It makes Twitter experience somewhat like that of IRC, faciliating knee-jerk reactions and misunderstandings. And the limit is severe even for casual conversation to the point that it had to be changed once emojis broke its core assumptions. I don't think Base65536 has much use outside of Twitter and likes.