6 ms·

Can we please change this to the actual study rather than this somewhat suspect-looking personal blog of a guy who is trying to sell books about vitamins and su

Can we please change this to the actual study rather than this somewhat suspect-looking personal blog of a guy who is trying to sell books about vitamins and supplements? https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub https://www.sciencedirect.com/science/article/pii/S096007602... The difference they report there between patients receiving calcifediol (Vitamin D) and those that do not is strikingly large, to the point where it makes me somewhat suspicious: > Of 50 patients treated with calcifediol, one required admission to the ICU (2%), while of 26 untreated patients, 13 required admission (50%) If that is true and replicates in larger sample sizes this would be an incredible powerful drug, wouldn't it?

neuronic 6y ago
And it would tell us heaps about how serious vitamin D deficiency (and likely other deficiencies) can really be. If, for example, reports of large amounts of African Americans being vitamin D deficient are true and vitamin D plays a significant role in many pathologies, safely getting those people to the right level without inducing vitaminosis could possibly lead to improvements in health issues that occur with higher incidence in African Americans (asthma comes to mind). It would have huge benefits to individuals and by extension healthcare systems. For everyone reading this, please make sure to get blood work done before supplementing more than 1000 or 2000 IU per day. Taking vitamin D in its complete and ready form sidesteps the bodies regulation mechanism because that happens before the body produces vitamin D from components after sun exposure. Taking it orally basically skips that regulation and therefore you CAN overdose with potentially severe health consequences.
- yehosef 6y ago
  >For everyone reading this, please make sure to get blood work done before supplementing more than 1000 or 2000 IU per day. rewritten for to be more actionable: For everyone reading this, make sure to take 1000 or 2000 IU per day since you may be deficient (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259547/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259547/). You should, if possible, get a blood test to see if you are severely deficient and if so to take higher doses according to your doctor's recommendation.
  - deleted 6y ago
    [deleted]
  - gremlinsinc 6y ago
    I'm deficient even AFTER taking 5000 iu's. I added a multi w/ 7500, figure I'll maybe add some more if I get covid. I had gastric sleeve though, so I have some absorption issues.
amelius 6y ago
> Can we please change this to the actual study It was discussed a few days ago here on HN: https://news.ycombinator.com/item?id=24366006 https://news.ycombinator.com/item?id=24366006 In any case, I think it is still nice to have a good article written in layman's terms that we can share with friends and family.
stevespang 6y ago
In fact, the Spanish study is distorted since it also involved hydroxychloroquine (400 mg every 12 hours on the first day, and 200 mg every 12 hours for the following 5 days), azithromycin (500 mg orally for 5 days. It's not vit. D alone, and yes, the guy is rather obviously promoting sales of his vitamin booklet.
LargoLasskhyfv 6y ago
That blog prominently links to said study in the first sentence, which I instantly clicked on to know what he even is talking ... err writing about. What is your problem?

neuronic 6y ago

And it would tell us heaps about how serious vitamin D deficiency (and likely other deficiencies) can really be. If, for example, reports of large amounts of African Americans being vitamin D deficient are true and vitamin D plays a significant role in many pathologies, safely getting those people to the right level without inducing vitaminosis could possibly lead to improvements in health issues that occur with higher incidence in African Americans (asthma comes to mind). It would have huge benefits to individuals and by extension healthcare systems. For everyone reading this, please make sure to get blood work done before supplementing more than 1000 or 2000 IU per day. Taking vitamin D in its complete and ready form sidesteps the bodies regulation mechanism because that happens before the body produces vitamin D from components after sun exposure. Taking it orally basically skips that regulation and therefore you CAN overdose with potentially severe health consequences.

yehosef 6y ago
>For everyone reading this, please make sure to get blood work done before supplementing more than 1000 or 2000 IU per day. rewritten for to be more actionable: For everyone reading this, make sure to take 1000 or 2000 IU per day since you may be deficient (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259547/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259547/). You should, if possible, get a blood test to see if you are severely deficient and if so to take higher doses according to your doctor's recommendation.
- deleted 6y ago
  [deleted]
- gremlinsinc 6y ago
  I'm deficient even AFTER taking 5000 iu's. I added a multi w/ 7500, figure I'll maybe add some more if I get covid. I had gastric sleeve though, so I have some absorption issues.

amelius 6y ago

> Can we please change this to the actual study It was discussed a few days ago here on HN: https://news.ycombinator.com/item?id=24366006 https://news.ycombinator.com/item?id=24366006 In any case, I think it is still nice to have a good article written in layman's terms that we can share with friends and family.

stevespang 6y ago

In fact, the Spanish study is distorted since it also involved hydroxychloroquine (400 mg every 12 hours on the first day, and 200 mg every 12 hours for the following 5 days), azithromycin (500 mg orally for 5 days. It's not vit. D alone, and yes, the guy is rather obviously promoting sales of his vitamin booklet.

LargoLasskhyfv 6y ago

That blog prominently links to said study in the first sentence, which I instantly clicked on to know what he even is talking ... err writing about. What is your problem?