4 ms·

I am disabled with Anxiety and Mood Disorder and chronic fatigue/depression. Typical "Bipolar" presentation. It runs in my family on my mothers side. We also ha

by podgaj 6y ago

I am disabled with Anxiety and Mood Disorder and chronic fatigue/depression. Typical "Bipolar" presentation. It runs in my family on my mothers side. We also have a history of early (45 years old) heart disease. So I knew this was mitochondrial but it was revealed when I received my genome. We have issues with our electron transport chain; Complex I (ND1 and ND4) and Complex III (MT-CYB). So diet and lifestyle was crucial in getting me off all of my meds, and I was on a lot. High dose riboflavin was a huge help. Getting complex I to work well helps with the heart since it increases NAD. Also getting enough ubiquinone from diet helps. I get it mostly from seafood like Salmon and Liver. I might try and take a CoQ10 supplement soon. But the fact that we make it endogenously makes me think it is not needed. Statins will stop the production of CoQ10 by lowering FPPP production which is why they fail to help people with Heart Disease. Balancing the flow and the oxidative stress from the mitochondrial electron transport chain is crucial.

tokai 6y ago
Did you ever take lithium?
- podgaj 6y ago
  Yes, both carbonate and orate. The carbonate, well that flattened me out of course, but it did not make me feel as good as I do now. (Which is not that good but much much better.) The ortate I took as an experiment wen I was more recently depressed and it made me hypomanic. This makes sense if you know Lithium inhibits IMPase and IPPase. And on the other side GSK-3. It is only at high doses that you get the NMDA and GABA effects. Which is too high IMHO. I still rely on Klonopin now and then when I mess up. (No, I do not take it everyday and I take the lowest dose possible, so don't bother telling me how dangerous it is.)
  - tokai 6y ago
    Thank you for your answer.
pete762 6y ago
> I am disabled with Anxiety and Mood Disorder and chronic fatigue/depression. Typical "Bipolar" presentation. It runs in my family on my mothers side. That sounds awfully familiar. Would you be so kind to provide any starting point to begin research into this, including the supplement stuff you mentioned afterwards?
- podgaj 6y ago
  I would start by getting your full genome run, or at least get it from Ancestry. Then learn how to look at the low frequency SNPs. I am lucky as I live near UNC Chapel Hill that has several departments looking into this stuff. The supplements came after I saw my genetics and from past anecdotal experiments. But maybe start by understanding the electron Transport chain. When I saw all the oxidative stress created there I began looking at the several pathways for the flow of O2- and H2O2. To me, mood disorders have their root in this flow being unobstructed. Riboflavin ended up being big for me for several reasons. Keep in mind, mood disorders are polygenic, may causes, so for you it might be something with Monoamines or what ever. I wish doctors would get serious about testing for these deficiencies in people wit mood disorders...
  - jackspawn 6y ago
    Can you tell me which SNPs were relevant for you? Or are generally relevant for depression? I checked https://www.snpedia.com/index.php/Depression https://www.snpedia.com/index.php/Depression but maybe you know better which SNPs are most important? I got my genome and checked it using promethease, but 'sadly' I didnt get any major 'depression' hit; only minor SNPs which were correlated with 1.5x more probability to get depression And I got no advice on which diet could help me :)
slfnflctd 6y ago
> Statins will stop the production of CoQ10 by lowering FPPP production which is why they fail to help people with Heart Disease I would like to know more about this. I've been on a statin for several years and feel like my energy has dropped through the floor in that time. I also feel like I have a 'statin hangover' when I wake up in the morning (I usually take it with my supper). This could all be correlation, and aside from cholesterol levels I haven't been diagnosed with heart disease. But I would like to know more, because I hate taking this stuff and really don't like the idea of being on it the rest of my life.
- podgaj 6y ago
  This is pretty much all you need to know: https://ubiquinol.org/sites/default/files/statins.gif https://ubiquinol.org/sites/default/files/statins.gif The thinking on cholesterol and heart disease is changing rapidly and there really is no strong evidence high cholesterol before a heart attack leads to any bad outcomes. After a heart attack, statins are ok. But like we see, side effects. My doc wanted me on them but they gave my mother horrible myopathy so I passed. My HDL was really low until I took out all plant oils and eat fats pretty much only from fish and olive oil. Now my HDL in mid range normal. This is becasue the omega 3 helps with reverse cholesterol transport. But again, this is me and my genetics. We have Saami (Inuit) heritage which is why I think i need this diet.
amirbehzad 6y ago
How did you get your genome?
tahoeskibum 6y ago
I'm in a similar situation. I've found that taking CoQ10 and NAD+ (e.g. Niagen or Elysium Basis) has been helpful.

by podgaj 6y ago

tokai 6y ago

Did you ever take lithium?

podgaj 6y ago
Yes, both carbonate and orate. The carbonate, well that flattened me out of course, but it did not make me feel as good as I do now. (Which is not that good but much much better.) The ortate I took as an experiment wen I was more recently depressed and it made me hypomanic. This makes sense if you know Lithium inhibits IMPase and IPPase. And on the other side GSK-3. It is only at high doses that you get the NMDA and GABA effects. Which is too high IMHO. I still rely on Klonopin now and then when I mess up. (No, I do not take it everyday and I take the lowest dose possible, so don't bother telling me how dangerous it is.)
- tokai 6y ago
  Thank you for your answer.

pete762 6y ago

> I am disabled with Anxiety and Mood Disorder and chronic fatigue/depression. Typical "Bipolar" presentation. It runs in my family on my mothers side. That sounds awfully familiar. Would you be so kind to provide any starting point to begin research into this, including the supplement stuff you mentioned afterwards?

podgaj 6y ago
I would start by getting your full genome run, or at least get it from Ancestry. Then learn how to look at the low frequency SNPs. I am lucky as I live near UNC Chapel Hill that has several departments looking into this stuff. The supplements came after I saw my genetics and from past anecdotal experiments. But maybe start by understanding the electron Transport chain. When I saw all the oxidative stress created there I began looking at the several pathways for the flow of O2- and H2O2. To me, mood disorders have their root in this flow being unobstructed. Riboflavin ended up being big for me for several reasons. Keep in mind, mood disorders are polygenic, may causes, so for you it might be something with Monoamines or what ever. I wish doctors would get serious about testing for these deficiencies in people wit mood disorders...
- jackspawn 6y ago
  Can you tell me which SNPs were relevant for you? Or are generally relevant for depression? I checked https://www.snpedia.com/index.php/Depression https://www.snpedia.com/index.php/Depression but maybe you know better which SNPs are most important? I got my genome and checked it using promethease, but 'sadly' I didnt get any major 'depression' hit; only minor SNPs which were correlated with 1.5x more probability to get depression And I got no advice on which diet could help me :)

slfnflctd 6y ago

> Statins will stop the production of CoQ10 by lowering FPPP production which is why they fail to help people with Heart Disease I would like to know more about this. I've been on a statin for several years and feel like my energy has dropped through the floor in that time. I also feel like I have a 'statin hangover' when I wake up in the morning (I usually take it with my supper). This could all be correlation, and aside from cholesterol levels I haven't been diagnosed with heart disease. But I would like to know more, because I hate taking this stuff and really don't like the idea of being on it the rest of my life.

podgaj 6y ago
This is pretty much all you need to know: https://ubiquinol.org/sites/default/files/statins.gif https://ubiquinol.org/sites/default/files/statins.gif The thinking on cholesterol and heart disease is changing rapidly and there really is no strong evidence high cholesterol before a heart attack leads to any bad outcomes. After a heart attack, statins are ok. But like we see, side effects. My doc wanted me on them but they gave my mother horrible myopathy so I passed. My HDL was really low until I took out all plant oils and eat fats pretty much only from fish and olive oil. Now my HDL in mid range normal. This is becasue the omega 3 helps with reverse cholesterol transport. But again, this is me and my genetics. We have Saami (Inuit) heritage which is why I think i need this diet.

amirbehzad 6y ago

How did you get your genome?

tahoeskibum 6y ago

I'm in a similar situation. I've found that taking CoQ10 and NAD+ (e.g. Niagen or Elysium Basis) has been helpful.