6 ms·

Autoimmune diseases are becoming more common[0] and so we will need to better understand them to maintain the health of the population. If the evolution of thes

Autoimmune diseases are becoming more common[0] and so we will need to better understand them to maintain the health of the population. If the evolution of these Siglecs could be better understood perhaps that would provide an insight into what causes them to go haywire and target our own tissues. I wonder what environmental factors could be at play given that the rise in autoimmune disease is so recent and sharp. Do we for example ever see autoimmune disease in our animal relatives with similar immune systems, e.g new world monkeys? [0]https://www.technologynetworks.com/immunology/news/amp/autoimmune-conditions-are-on-the-rise-333244 https://www.technologynetworks.com/immunology/news/amp/autoi...

salawat 6y ago
Likely, we're living much longer, and most other things we'd die from before an ill-tuned immune system due to post-sexual maturity thymus atrophy became a problem aren't killing us as often anymore. That at least explains the prevalence of old-age related autoimmune problems. Not so up to date with regards to the younger folks or genetics linked ones though.
ccffpphh 6y ago
The rise in autoimmune diseases is probably due to higher inflammation levels due to the trend of steadily increasing levels of sugar consumption and seed oils amongst western societies - same reason heart disease continues to be a killer.
- wobbly_bush 6y ago
  > probably due to higher inflammation levels due to the trend of steadily increasing levels of sugar consumption and seed oils Any resources where I can read up more about this?
  - partyboat1586 6y ago
    I've got one for the seed oils http://raypeat.com/articles/articles/unsaturated-oils.shtml http://raypeat.com/articles/articles/unsaturated-oils.shtml Afaik sugar is not inflammatory though.
    - labawi 6y ago
      > Plants produce many protective substances to repel or injure insects and other animals that eat them. They produce their own pesticides. The oils in seeds have this function. > I use some of these oils (walnut oil ..) for oil painting, but I am careful to wash my hands thoroughly after.. The fats in nuts are obviously there to poison those who eat it, same as sugar in fruit. > Cancer can't occur, unless there are unsaturated oils in the diet. There might be an interesting connection, but I wouldn't take Mr. Peat's statements at face value.
      - partyboat1586 6y ago
        The sugar in fruit is not poisonous and encourages you to eat it so you can carry the seeds to another location but you're not meant to chew or digest the seeds. Nuts are similar to seeds in this way. >Cancer can't occur, unless there are unsaturated oils in the diet. This does seem like a dubious statement.
        labawi 6y ago
        Many plants have seeds with ample sugars, fats, and/or protein, yet no nutritious or enticing exterior. Is the preferred evolutionary strategy falling to the ground and poisoning anything that dares to eat you? Obviously spreading doesn't work if all of the seeds are eaten, but I've seen walnuts spread far and quite effectively (multiple saplings yearly) - presumably by crows failing to crack a nut, mice not eating some of their gatherings or similar methods. BTW the fruity part of walnuts is definitely poisonous, as are the leaves and maybe even the wood, but the nuts are fine and nutritious.
  - treeman79 6y ago
    Loop up AIP diets
- ford_o 6y ago
  Interesting. I have never heard about seed oil over consumption being an issue.
- treeman79 6y ago
  This. I have an autoimmune. and follow many groups Eventually people realize diet is the biggest area they need improvement. Plain Sweet potatoes are my go to for low inflammation food. I do so much better on them.

salawat 6y ago

Likely, we're living much longer, and most other things we'd die from before an ill-tuned immune system due to post-sexual maturity thymus atrophy became a problem aren't killing us as often anymore. That at least explains the prevalence of old-age related autoimmune problems. Not so up to date with regards to the younger folks or genetics linked ones though.

ccffpphh 6y ago

The rise in autoimmune diseases is probably due to higher inflammation levels due to the trend of steadily increasing levels of sugar consumption and seed oils amongst western societies - same reason heart disease continues to be a killer.

wobbly_bush 6y ago
> probably due to higher inflammation levels due to the trend of steadily increasing levels of sugar consumption and seed oils Any resources where I can read up more about this?
- partyboat1586 6y ago
  I've got one for the seed oils http://raypeat.com/articles/articles/unsaturated-oils.shtml http://raypeat.com/articles/articles/unsaturated-oils.shtml Afaik sugar is not inflammatory though.
  - labawi 6y ago
    > Plants produce many protective substances to repel or injure insects and other animals that eat them. They produce their own pesticides. The oils in seeds have this function. > I use some of these oils (walnut oil ..) for oil painting, but I am careful to wash my hands thoroughly after.. The fats in nuts are obviously there to poison those who eat it, same as sugar in fruit. > Cancer can't occur, unless there are unsaturated oils in the diet. There might be an interesting connection, but I wouldn't take Mr. Peat's statements at face value.
    - partyboat1586 6y ago
      The sugar in fruit is not poisonous and encourages you to eat it so you can carry the seeds to another location but you're not meant to chew or digest the seeds. Nuts are similar to seeds in this way. >Cancer can't occur, unless there are unsaturated oils in the diet. This does seem like a dubious statement.
      - labawi 6y ago
        Many plants have seeds with ample sugars, fats, and/or protein, yet no nutritious or enticing exterior. Is the preferred evolutionary strategy falling to the ground and poisoning anything that dares to eat you? Obviously spreading doesn't work if all of the seeds are eaten, but I've seen walnuts spread far and quite effectively (multiple saplings yearly) - presumably by crows failing to crack a nut, mice not eating some of their gatherings or similar methods. BTW the fruity part of walnuts is definitely poisonous, as are the leaves and maybe even the wood, but the nuts are fine and nutritious.
- treeman79 6y ago
  Loop up AIP diets
ford_o 6y ago
Interesting. I have never heard about seed oil over consumption being an issue.
treeman79 6y ago
This. I have an autoimmune. and follow many groups Eventually people realize diet is the biggest area they need improvement. Plain Sweet potatoes are my go to for low inflammation food. I do so much better on them.