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An LSD Trip “Off-Switch” May Be Coming Soon
- wreet 6y agoWe already have one. Give someone having a bad trip a Xanax and they're good.
- Nursie 6y agoDo benzodiazepines actually switch it off, or just allow the participant to relax (and maybe sleep it off)?
- Tenoke 6y agoBit of both but more the latter.
- TheSpiceIsLife 6y agoIn my experience they turn the trip off. You can still be awake, but you won’t be tripping any more, the sleep only comes if you actually lay down and try to go to sleep or take a large enough dose of benzos.
- wreet 6y agoSame. I've never had to use it to abort a trip personally, but I've seen it done and the person said it turned it off too.
- merlehaggard 6y agoThey dampen the effects and quell the anxiety, and depending on what stage of the trip you're in and how hard you're tripping they may effectively kill it entirely. I would take a bit of valium on the tail end of a trip to sleep or quiet my brain as it reconstituted itself after being atomized into the cosmos. I only took benzos once during the upward trajectory of a trip near the peak, after suffering physical panic symptoms from a strong batch of wild-picked wavy caps (first and only time I've felt physically threatened by a psychedelic). It didn't kill the trip, but it killed the panic and allowed me to enjoy the experience.
- JimBlackwood 6y agoSome magnesium tablets also work great.
- throwaway287391 6y agoInteresting, I didn't know that. Now I wish I'd had a Xanax after my one trip which kept me awake until 4-5 am after taking acid around noon (otherwise it was an incredible day, it was just annoying not being able to sleep). Don't benzos have some pretty nasty side effects and/or dependency potential though? Maybe this drug is a bit more targeted / less risky?
- np_tedious 6y agoDependency issues, some memory loss, coordination. Real concerns if you're going to take it every day or drive or something. Nothing that would present a serious issue for this kind of occasional use.
- W4ldi 6y agoXanax is a short-acting benzodiazepine
- layoutIfNeeded 6y agoBenzos are given to hundreds of millions of people every year, so they're pretty safe in my opinion. But they must not be taken for longer than a few weeks and/or in high doses! Because if you stop them cold turkey, you can die from the withdrawal effects (seizures).
- W4ldi 6y agoThing with most drugs is - we barely know which long-term/not clearly traceable side effects they have. We have these big issues like heart attacks, strokes, cancer, mental issues, gene defects - all of which don't have obvious causes but surely increased with pollution, drugs and chemicals
- goatsi 6y agoWe are starting to find out the long-term effects of benzos, and it doesn't look good: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325366/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325366/
- dzhiurgis 6y agoHow about alcohol? I’ve only had one third of a trip and towards the end whiskey took some of the edge off.
- fiblye 6y agoYeah, I’ve found having a beer definitely takes away some anxiety/twitchiness and brings me back to reality a bit faster. But it was the same for me, towards the end of a trip. Not sure how it works for somehow rapidly being swallowed by the void.
- isoprophlex 6y agoIn my experience, the acid smashes straight through the effects of the alcohol. I drank quite a lot during the peak once, it didnt affect me at all. (Mind you my trip was okay, no anxiety i wanted to get rid of.) The tail end was pretty rough though, getting slammed back into reality AND a nasty hangover wasn't fun. All in all it felt pretty pointless. Not recommended.
- dzhiurgis 6y ago"He need sum milk" also comes to mind
- mschuster91 6y agoNever, ever, mix any other drug with alcohol - or for that matter don't mix any kind of drugs unless you are specifically aware of the purity, the amounts consumed and the interactions between the agents, and are under the supervision of a doctor. If there is one thing that carries a real risk of fucking up (other than ODing) it is mix consumption.
- forgotmypw17 6y agoOr a bit of MDMA
- LilBytes 6y agoThis does not get you out of a trip. This is called candy clipping and has the opposite affect.
- dylkil 6y agothis will lengthen the trip by alot
- xutopia 6y agoMDMA will not reduce the effects of LSD but remove the element of fear and bring your imagination into more pleasant areas. This is something that Rick Doblin, the founder of MAPS, describes in the latest Tim Ferriss podcast.
- jokowueu 6y agoJust wanted to say thanks for bringing attention to this interview . I really enjoy Rick's thoughts on these issues
- thoughtpalette 6y ago
- sjnair96 6y agoAntipsychotics seem theoretically (and by online accounts empirically) more effective. While benzos reduce the panic, antipsychotics would function more similarly to an off-switch.
- elevenoh 6y agoYep
- DanBC 6y agoBenzos can have a paradoxical effect of increasing distress and disturbance.
- stephenitis 6y agoNot loading. Internet hug of death? Anyone describe what they are talking about?
- throwaway4666 6y agoWon't load for me either. No archive caching either :/
- throwaway287391 6y agoCached: https://webcache.googleusercontent.com/search?q=cache:fL9NNmjWngkJ:https://www.freethink.com/articles/lsd-trip https://webcache.googleusercontent.com/search?q=cache:fL9NNm...
- renewiltord 6y agoXanax?
- INTPenis 6y agoI came here to see this. We didn't have Xanax in Sweden growing up but we did carry Valium or Xanor. Xanor has the same active ingredient as Xanax. Someone claimed Valium would help too but I doubt it. I only ever heard of this being used once to stop a bad trip, and I wasn't present.
- smabie 6y agoAll benzos are pretty much the same, why would xanax work but not valium?
- entropyneur 6y agoSo no info on what it actually is. Just some company filing a patent. And the fact that they call it "a neutralizer technology" suggests that it's probably just a bunch of BS combined with previously known drugs to make it patentable. I'm pretty sure there's at least some published research on using at least one antipsychotic for that and mountains of "folk research" on using benzodiazepines.
- fabiomaia 6y agoProbably just benzodiazepines labeled "LSD off switch" to make money off the increasing interest in psychedelics.
- throwaway4666 6y agoYeah marketing something widely known to make it palatable and "provide liability" isn't new. See e.g. Scott Alexander's piece on literal fish oil: https://slatestarcodex.com/2014/06/15/fish-now-by-prescription/ https://slatestarcodex.com/2014/06/15/fish-now-by-prescripti...
- raverbashing 6y agoHah. This article is not only golden, but got me deeply annoyed with all BS machine it exposes Spoiler alert > And I used to think that the alternative medicine people were overestimating how evil Big Pharma was. But now I know that’s not right. > Now I know they’re underestimating it. (though I understand a bit of the issues behind the BRCA gene testing thing and I'm not sure it continues to be banned or merely the results need to be more generic and not just "you have X% of having cancer")
- im3w1l 6y agoThere have been way too many scandals around supplement purity for me to buy into his narrative. Like if someone told me a given brand of fish oil supplements contained 10% of the stated dose, was rancid and full of heavy metals I wouldn't be the least surprised. But if a fish oil medicine had those issues, I would be shocked, because the consequences for the guilty party would be much bigger, a huge circus of lawsuits and people losing their licenses. That's how I imagine it anyway.
- dotcoma 6y agoThat's terrible. We're going to have fewer 'unicorns' ;-)
- quickthrower2 6y agoI'll stick to RCD trip off switches :-)
- tartoran 6y agoWhats that?
- quickthrower2 6y agoResidual Current Device - a circuit breaker that opens a circuit when too much current is not returned via neutral, implying leakage to earth. They “trip” too and with the similarity to LSD, a TLA ending in D! I couldn’t resist the joke.
- dkmar 6y agonote: i’m not a doctor or anything related. Wikipedia says “5-HT2A antagonists block the psychedelic activity of LSD”[0], so wouldn’t 5-ht2a antagonists like mirtazapine work well enough here? No idea as to how quickly the trip would be tempered, though [0]: https://en.m.wikipedia.org/wiki/Lysergic_acid_diethylamide https://en.m.wikipedia.org/wiki/Lysergic_acid_diethylamide
- QUFB 6y agoYes, or at least it blocks effects if you take it pre-exposure. Risperidone, an atypical antispychotic, is also known for this. Some idiotic big pharma startup will try and milk this, rather than examining cheap existing medications. Plenty of medications block 5-HT2A, I think the important requirement here would be rapid absorption and high receptor occupancy.
- c22 6y agoAnecdotally, I've used risperidone specifically to abort LSD trips on two occasions and found it quite successful both times. Now when I introduce people to LSD I give them a Risperdal to keep in their pocket "just in case", though to my knowledge none of them have had to use it.
- penagwin 6y agoSimply knowing you have a backup strategy if you panic can go a long way to preventing panic attacks. Psychiatrists sometimes do something similar where they write a script for a benzo, just one or two for your bag. Knowing you can control panic if it occurs goes such a ways in preventing panic at all.
- indenturedsmile 6y agoAnecdotally, one of the best treatments for social anxiety I've found is to always know where the exits are. At a concert, identify the exit signs. In a conversation, have someone who can take over for you. Knowing there's a way out of the situation can completely nullify the scariness of that situation.
- deleted 6y ago[deleted]
- 34679 6y agoThe old urban legend is that Vitamin D brings you down and Vitamin C, up. Milk if tripping too hard, orange juice to trip harder.
- Dumblydorr 6y agoThat's a folksy legend indeed, where is that from? The 1960s?
- 34679 6y agoI'm not sure how far back it goes, but it was popular in the 90's.
- frandroid 6y agoI don't know about LSD, but definitely milk for muting a shroom trip...
- thanatos519 6y agoWhat was wrong with Niacin? 1500mg of Niacin stops it in less than 20 minutes for me.
- dylan604 6y agoIt seems odd (in a funny manner) that you'd need 1500mg of something to counter the micrograms of the thing you previously took.
- dmerrick 6y agoI think this is pretty normal in biology. Like how someone might have to drink 2L of water to feelbetter after a few shots of alcohol
- deleted 6y ago[deleted]
- carapace 6y agoYeah, FWIW, R. A. Wilson talks about how B3 was known anecdotally back in the 70's in "Sex and Drugs" as good for bad trips. https://en.wikipedia.org/wiki/Sex,_Drugs_and_Magick https://en.wikipedia.org/wiki/Sex,_Drugs_and_Magick
- chillingeffect 6y agoOn a related note, lavender oil and theanine have recently been (preliminarily) shown to increase the likelihood of a good trip: https://www.reddit.com/r/shrooms/comments/gwh87x/scientific_revelations_about_what_causes_good_and/ https://www.reddit.com/r/shrooms/comments/gwh87x/scientific_... which references this article: https://www.nature.com/articles/s41386-020-0718-8 https://www.nature.com/articles/s41386-020-0718-8
- MMM13SFH 6y agoIt's called Seroquel
- MMM13SFH 6y agoIt already exists it's called Seroquel or benzos
- yummypaint 6y agoNow im curious how effective a placebo is at ending a bad trip
- 1MachineElf 6y agoTo be honest, I'm more interested in an easy to acquire "On-Switch" than anything else.
- hkai 6y agoOn Reddit you would be instabanned for a post like this
- fsewe20 6y agobuy monero, download tor, dark.fail next day trip.
- metadaemon 6y agoYou can also do, smart phone currency app to buy tokens -> morphtoken exchange to Monero -> Tails OS -> dark.fail
- anaisbetts 6y agoSmart phone currency app? What's an example?
- squegles 6y agoCoinbase:usd2btc -> Binance:btc2xmr
- baby 6y agowhat market though?
- jokowueu 6y agoThey aren't being clear on what they are doing exactly but Why not just use Ketanserin. It's what they have been using on mice for a while now .
- KhoomeiK 6y agoPeople regularly use Trazodone [1] as a trip killer. I personally haven't and I don't like using them, but it does its job pretty well from what I've heard. [1] https://en.wikipedia.org/wiki/Trazodone https://en.wikipedia.org/wiki/Trazodone
- 420codebro 6y agoLmao I can confirm that Trazodone will put you OUT. I have never tried LSD or used Trazodone as a post-peak downer, but when using it for general anxiety management I found it very powerful.
- steveharman 6y ago"On April 1, MindMed announced...". Haven't their marketing droids heard of April Fool's Day? Or is it just a UK thing...
- stanfordkid 6y agoWow. So basically they re-invented Xanax? :P Joking aside, No way there is any chance that you would stick this in a human (huge potential for harm, no real clinical use case). LSD is an insanely potent 5HT agonist, it seems highly unlikely any drug that is not "serious" would cause any significant reduction in LSD effects. Benzo's like Xanax can make the trip go in a direction that is less negative... but you are still tripping balls.
- chasers 6y agoKind of defeats the purpose. If you can bail you don't have to figure it out.
- pageandrew 6y agoSometimes trips can really get out of your control and can get pretty scary... might make sense to allow people to bail from that.
- heavyset_go 6y agoAny competitive 5-HT2A antagonist will block psychedelic effects from classical psychedelic drugs, and D2 antagonists will block the potential for stimulant-esque psychosis that drugs like LSD can trigger through dopamine agonism. There are probably hundreds of drugs that fall into these classes, and many of them have significant clinical data to derive their safety profiles from. If someone comes into a hospital with a bad reaction to psychedelic drugs, it's not uncommon for them to be given something like risperidone, both a 5-HT2A and D2 antagonist, and an anxiolytic to calm them down.
- LockAndLol 6y ago>LSD has been classified in the vast majority of countries as a Schedule 1 illegal drug for more than 50 years, ever since the adoption of the United Nations' Convention on Psychotropic Substances. >That scheduling means regulators believe the drug has "no currently accepted medical use" — and according to scientists from Imperial College London's Centre for Psychedelic Research, it's had a hugely negative impact on LSD research. The US fucked up a lot of research forcing other countries to sign that convention.
- prvc 6y agoAre there typically lingering physiological effects on the brain after taking LSD? Would this counteract those, or merely the psychological aspects?