I've not heard of anything patched outside of paths being changed by patchelf. This is done because any dependencies are being stored inside the nix store under

I've not heard of anything patched outside of paths being changed by patchelf. This is done because any dependencies are being stored inside the nix store under a hash of their dependency trees, which allows for multiple versions of the same dependency to exist without conflict. You should find that the NixOS community has no problem with producing the nix file to make NixOS support possible for your open source DAW.