4 ms·
You are dangerously misinformed. RNA polymerase requires Zinc. In fact, I believe essentially all polymerases known use Zinc as a core component of their cata
by hcknwscommenter 6y ago
You are dangerously misinformed. RNA polymerase requires Zinc. In fact, I believe essentially all polymerases known use Zinc as a core component of their catalytic chemistry.
- pdonis 6y ago> You are dangerously misinformed. No, you are: https://jvi.asm.org/content/91/21/e00754-17 https://jvi.asm.org/content/91/21/e00754-17 Paper title: "Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase" Published in 2017. https://pubmed.ncbi.nlm.nih.gov/21079686/ https://pubmed.ncbi.nlm.nih.gov/21079686/ Paper title: "Zn(2+) Inhibits Coronavirus and Arterivirus RNA Polymerase Activity in Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture" Published in 2010.
- dekhn 6y agoThe person you replied to is technically correct: DNA-dependent RNA polymerases are zinc metalloenzymes, have zinc at the active site, and the zinc is required for catalytic functionality.