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And, as we have since learnt, HCQ doesn't help and is actively harmful. These two brothers are also not the same person, so it's entirely possible for one of t

And, as we have since learnt, HCQ doesn't help and is actively harmful. These two brothers are also not the same person, so it's entirely possible for one of them to ban something while the other still wants to use it.

kangaroozach 6y ago
That is false. HCQ is a zinc ionophore, and thus can shuttle zinc into the infected cells to inhibit RNA Polymerase, thereby inhibiting viral replication. Studies all over the world have supported this. HCQ with zinc EARLY on is very likely helpful and many have attributed this to saving their life. Also given the long-standing risk profile of HCQ as an anti-malarial treatment and indicates that there are quite limited risks and side effects unless the patient has certain heart conditions or certain other specific and easy to know about conditions. Fake news points to studies that don’t test the key combo of “HCQ+Zinc+Early”. Any other combo may fail, but that does not mean that this combo is not effective.
- hcknwscommenter 6y ago
  You are dangerously misinformed. RNA polymerase requires Zinc. In fact, I believe essentially all polymerases known use Zinc as a core component of their catalytic chemistry.
  - pdonis 6y ago
    > You are dangerously misinformed. No, you are: https://jvi.asm.org/content/91/21/e00754-17 https://jvi.asm.org/content/91/21/e00754-17 Paper title: "Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase" Published in 2017. https://pubmed.ncbi.nlm.nih.gov/21079686/ https://pubmed.ncbi.nlm.nih.gov/21079686/ Paper title: "Zn(2+) Inhibits Coronavirus and Arterivirus RNA Polymerase Activity in Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture" Published in 2010.
    - dekhn 6y ago
      The person you replied to is technically correct: DNA-dependent RNA polymerases are zinc metalloenzymes, have zinc at the active site, and the zinc is required for catalytic functionality.
- hcknwscommenter 6y ago
  "unless the patient has certain heart conditions" Sorry for the multiple posts, but this is an absurd statement. COVID itself is a heart condition. HCQ for COVID is dangerous.
- IAmEveryone 6y ago
  The science has moved to "evidence-based medicine", i. e. pure empiricism, about 80 years ago? I know such theories always sound convincing. So did miasmas, and blood-letting, and so on. But that way of thinking just never worked!
m0zg 6y ago
We have learned no such thing. The study WHO is referring to is fake: https://www.theguardian.com/world/2020/may/29/covid-19-surgisphere-hydroxychloroquine-study-lancet-coronavirus-who-questioned-by-researchers-medical-professionals https://www.theguardian.com/world/2020/may/29/covid-19-surgi... You're being gaslit.

kangaroozach 6y ago

That is false. HCQ is a zinc ionophore, and thus can shuttle zinc into the infected cells to inhibit RNA Polymerase, thereby inhibiting viral replication. Studies all over the world have supported this. HCQ with zinc EARLY on is very likely helpful and many have attributed this to saving their life. Also given the long-standing risk profile of HCQ as an anti-malarial treatment and indicates that there are quite limited risks and side effects unless the patient has certain heart conditions or certain other specific and easy to know about conditions. Fake news points to studies that don’t test the key combo of “HCQ+Zinc+Early”. Any other combo may fail, but that does not mean that this combo is not effective.

hcknwscommenter 6y ago
You are dangerously misinformed. RNA polymerase requires Zinc. In fact, I believe essentially all polymerases known use Zinc as a core component of their catalytic chemistry.
- pdonis 6y ago
  > You are dangerously misinformed. No, you are: https://jvi.asm.org/content/91/21/e00754-17 https://jvi.asm.org/content/91/21/e00754-17 Paper title: "Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase" Published in 2017. https://pubmed.ncbi.nlm.nih.gov/21079686/ https://pubmed.ncbi.nlm.nih.gov/21079686/ Paper title: "Zn(2+) Inhibits Coronavirus and Arterivirus RNA Polymerase Activity in Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture" Published in 2010.
  - dekhn 6y ago
    The person you replied to is technically correct: DNA-dependent RNA polymerases are zinc metalloenzymes, have zinc at the active site, and the zinc is required for catalytic functionality.
hcknwscommenter 6y ago
"unless the patient has certain heart conditions" Sorry for the multiple posts, but this is an absurd statement. COVID itself is a heart condition. HCQ for COVID is dangerous.
IAmEveryone 6y ago
The science has moved to "evidence-based medicine", i. e. pure empiricism, about 80 years ago? I know such theories always sound convincing. So did miasmas, and blood-letting, and so on. But that way of thinking just never worked!

m0zg 6y ago

We have learned no such thing. The study WHO is referring to is fake: https://www.theguardian.com/world/2020/may/29/covid-19-surgisphere-hydroxychloroquine-study-lancet-coronavirus-who-questioned-by-researchers-medical-professionals https://www.theguardian.com/world/2020/may/29/covid-19-surgi... You're being gaslit.