3 ms·

> this falls roughly under the same category as intelligent design debate: the claim is so exceptional that it's a priori unlikely to be found true No. As the

> this falls roughly under the same category as intelligent design debate: the claim is so exceptional that it's a priori unlikely to be found true No. As the person you're responding to pointed out: "The viruses that cause colds, many of which are also coronaviruses, are pretty adept at hitting people throughout their life."

deleted 7y ago
[deleted]
timr 7y ago
"No. As the person you're responding to pointed out: "The viruses that cause colds, many of which are also coronaviruses, are pretty adept at hitting people throughout their life."" Yes. I'm talking about the question of immunity, not whether or not it's possible to get re-infected by new strains of the same virus, or whether or not immunity fades over time. It would be unlikely that this virus didn't confer at least short-term immunity to the host. The viruses that cause colds primarily re-infect because they mutate at a very high rate. We aren't seeing that with this particular virus.
- f38zf5vdt 7y ago
  One of the currently popular mutants of the virus has a mutation in the proof-reading exonuclease that causes the virus to mutate much more often than the original strain. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02344-6 https://translational-medicine.biomedcentral.com/articles/10...
  - timr 7y ago
    "that causes the virus to mutate much more often than the original strain." This is not claimed anywhere in the paper you linked to. They show a non-synonymous mutation in RNA-dependent RNA polymerase, and hypothesized that it could impact drug resistance.
    - f38zf5vdt 7y ago
      My bad, I was misremembering the paper, which mentions the exonuclease's role in fidelity. I meant RdRps. The conclusion was the same. Figure 4 shows quite clearly that the RdRp mutation is associated with further mutations. > We found that viral strains with RdRp mutation have a median of 3 point mutations [range: 2–5], whereas viral strains with no RdRp mutation have a median of 1 mutation [range: 0–3] (p value < 0.001, Mann–Whitney test). The different distribution between the two groups relative to the number of mutations is statistically significant (Fig. 4).
amyjess 7y ago
Immunity != long-term immunity. You can get temporary immunity that lasts for a year or so and still be able to get reinfected multiple times in your life.
- mr_toad 7y ago
  And there are hundreds of strains and types of viruses that cause colds. Immunity to a rhinovirus serotype will not help with other serotypes of rhinovirus, let alone all the coronavirus strains and influenza viruses.
stale2002 7y ago
Hmmm, I think I am going to list to the other guy, who has a doctorate in viruses.

deleted 7y ago

[deleted]

timr 7y ago

"No. As the person you're responding to pointed out: "The viruses that cause colds, many of which are also coronaviruses, are pretty adept at hitting people throughout their life."" Yes. I'm talking about the question of immunity, not whether or not it's possible to get re-infected by new strains of the same virus, or whether or not immunity fades over time. It would be unlikely that this virus didn't confer at least short-term immunity to the host. The viruses that cause colds primarily re-infect because they mutate at a very high rate. We aren't seeing that with this particular virus.

f38zf5vdt 7y ago
One of the currently popular mutants of the virus has a mutation in the proof-reading exonuclease that causes the virus to mutate much more often than the original strain. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02344-6 https://translational-medicine.biomedcentral.com/articles/10...
- timr 7y ago
  "that causes the virus to mutate much more often than the original strain." This is not claimed anywhere in the paper you linked to. They show a non-synonymous mutation in RNA-dependent RNA polymerase, and hypothesized that it could impact drug resistance.
  - f38zf5vdt 7y ago
    My bad, I was misremembering the paper, which mentions the exonuclease's role in fidelity. I meant RdRps. The conclusion was the same. Figure 4 shows quite clearly that the RdRp mutation is associated with further mutations. > We found that viral strains with RdRp mutation have a median of 3 point mutations [range: 2–5], whereas viral strains with no RdRp mutation have a median of 1 mutation [range: 0–3] (p value < 0.001, Mann–Whitney test). The different distribution between the two groups relative to the number of mutations is statistically significant (Fig. 4).

amyjess 7y ago

Immunity != long-term immunity. You can get temporary immunity that lasts for a year or so and still be able to get reinfected multiple times in your life.

mr_toad 7y ago
And there are hundreds of strains and types of viruses that cause colds. Immunity to a rhinovirus serotype will not help with other serotypes of rhinovirus, let alone all the coronavirus strains and influenza viruses.

stale2002 7y ago

Hmmm, I think I am going to list to the other guy, who has a doctorate in viruses.