3 ms·

[IANAD] hydroxychloroquine is an immunosuppressant and shouldn't be combined even with vaccines ( https://www.medicinenet.com/hydroxychloroquine/article.htm#whi

by trhway 7y ago

[IANAD] hydroxychloroquine is an immunosuppressant and shouldn't be combined even with vaccines ( https://www.medicinenet.com/hydroxychloroquine/article.htm#which_drugs_or_supplements_interact_with_hydroxychloroquine_plaquenil https://www.medicinenet.com/hydroxychloroquine/article.htm#w... ), so using it when immune system is really fighting an infection may happen to be very antiproductive unless it is a case of COVID triggered cytokine storm (hyperinflammation) when such immunosuppressant is probably what you'd really want. May be it is a reason why in come cases of COVID it works and in some doesn't. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30628-0/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6... "However, in hyperinflammation, immunosuppression is likely to be beneficial. Re-analysis of data from a phase 3 randomised controlled trial of IL-1 blockade (anakinra) in sepsis, showed significant survival benefit in patients with hyperinflammation, without increased adverse events.8 A multicentre, randomised controlled trial of tocilizumab (IL-6 receptor blockade, licensed for cytokine release syndrome), has been approved in patients with COVID-19 pneumonia and elevated IL-6 in China " Notable fact is that majority of the deaths of the second wave (the deadliest, which in addition to children/weak/elderly was also strongly hitting healthy 25-35 years old) of Spanish flu was due to cytokine storm.

orwin 7y ago
Yes, obviously in case of hyperinflammation doctor are giving immunosuppressing drugs, HCQ or other depending on the stocks (and of course the patient history and other drugs given prior). They are very capable people in most cases, urgentists are often very knowledgable, and reanimation doctors are probably the best at interfering/preventing coktail effect. They are not available in all cases, but they try to be there for the most important ones. No one, no scientist is saying with certainty that HCQ does not work at all. However, the maxim is primum non nocere. Are HCQ effects important enough to use it in every case when you can do otherwise? Well, according to the last Raoult study on 80 mild cases, no. 3 hospitalisation, 1 death for 80 cases is around the same result as German/S.K. mild cases who are given no treatment at all (a bit superior, even, but n=80 is clearly not enough). Maybe HCQ reduce contagiosity. In this case, is HCQ more efficient than interferon? I know that i would prefer interferon as my liver and kidneys can take more hit than my heart atm (i already have a medication that cause tachycardia when i overdose it a little + some minor heart issues). Is HCQ more efficient than rinovir? this particular article seems to say that it's not but why should i trust this article more than Raoult and some French articles? Should i take everything (interferon, rinovir, HCQ, CQ) and hope for the best? Or, since i can afford to as i live in a rich country, should i wait the different study results?

by trhway 7y ago

orwin 7y ago

Yes, obviously in case of hyperinflammation doctor are giving immunosuppressing drugs, HCQ or other depending on the stocks (and of course the patient history and other drugs given prior). They are very capable people in most cases, urgentists are often very knowledgable, and reanimation doctors are probably the best at interfering/preventing coktail effect. They are not available in all cases, but they try to be there for the most important ones. No one, no scientist is saying with certainty that HCQ does not work at all. However, the maxim is primum non nocere. Are HCQ effects important enough to use it in every case when you can do otherwise? Well, according to the last Raoult study on 80 mild cases, no. 3 hospitalisation, 1 death for 80 cases is around the same result as German/S.K. mild cases who are given no treatment at all (a bit superior, even, but n=80 is clearly not enough). Maybe HCQ reduce contagiosity. In this case, is HCQ more efficient than interferon? I know that i would prefer interferon as my liver and kidneys can take more hit than my heart atm (i already have a medication that cause tachycardia when i overdose it a little + some minor heart issues). Is HCQ more efficient than rinovir? this particular article seems to say that it's not but why should i trust this article more than Raoult and some French articles? Should i take everything (interferon, rinovir, HCQ, CQ) and hope for the best? Or, since i can afford to as i live in a rich country, should i wait the different study results?