4 ms·

Be careful with NSAIDs as they may exacerbate symptoms. [1] [1]: https://www.theguardian.com/world/2020/mar/14/anti-inflammatory-drugs-may-aggravate-coronaviru

by Leary 7y ago

Be careful with NSAIDs as they may exacerbate symptoms. [1] [1]: https://www.theguardian.com/world/2020/mar/14/anti-inflammatory-drugs-may-aggravate-coronavirus-infection https://www.theguardian.com/world/2020/mar/14/anti-inflammat...

raphlinus 7y ago
Is there an authoritative source for this other than the French public health authorities? I haven't seen references to it at all in epi Twitter.
- throwaway_pdp09 7y ago
  Seems you're putting twitter above a country's health authority. That seems odd. Not necessarily wrong, just odd.
  - outworlder 7y ago
    Not necessarily wrong? I'm intrigued by the thought process.
    - raphlinus 7y ago
      I'm very happy to expand on my thought process. By "epi Twitter" I mean specifically experts I follow, over a wide range of specialties including disaster preparedness, epidemiology, public health, and related topics. These are among the best people in the field, and are kind enough to share with each other and the rest of us their expertise and thoughts through Twitter. It is awe-inspiring to see. At the same time on Twitter, and at much higher volume, is a torrent of bullshit, with apparently some seeding from active disinformation sources. I try to be very careful to filter this out, though it's not always easy (I find my curation much more effective on desktop web than mobile). Public health sources are sometimes wrong. For example, Ohio's chief public health doctor put out an estimate of 100k cases on 3/12, propagated through official channels including a tweet from the Governor [1], and which #epi Twitter very quickly criticized. Work out for yourself which to trust; among other things, with the CFR we're seeing, if the public health official is right we'd be seeing approximately 1k excess deaths in OH, with a timeframe that would certainly have started emerging by now. This particular thing (ibuprofen) is in the category of "emerging research which could be very important if and when it checks out." So basically I'm trying to be very careful to vet the information I transmit. The pipeline from that to actionable advice can sometimes be infuriatingly slow, which no doubt explains why certain things (especially with an easy-to-understand narrative) jump the queue. I will definitely put this in my resource list as soon as I see trustworthy confirmation. And I am confident that if it actually was valid and important, at least one of the experts I follow would have mentioned it by now. [1]: https://twitter.com/GovMikeDeWine/status/1238177953126604801 https://twitter.com/GovMikeDeWine/status/1238177953126604801
- diggan 7y ago
  Yeah, was published in Lancet https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/ https://www.thelancet.com/journals/lanres/article/PIIS2213-2...
  - raphlinus 7y ago
    That paper is about ACE inhibitors, not NSAIDs, and is specifically about patients with hypertension and diabetes, not the general population. Co-morbidity is apparently a huge driver of deaths, so research on these kinds of interactions is very important. But I think parent comment is a data point of evidence that the general public can't be trusted to interpret research.
searine 7y ago
This isn't clear yet. It is a reasonable assumption based on the biology but not verified.
yread 7y ago
Especially ibuprofen as it can cause water retention exacerbating pneumonia

by Leary 7y ago

raphlinus 7y ago

Is there an authoritative source for this other than the French public health authorities? I haven't seen references to it at all in epi Twitter.

throwaway_pdp09 7y ago
Seems you're putting twitter above a country's health authority. That seems odd. Not necessarily wrong, just odd.
- outworlder 7y ago
  Not necessarily wrong? I'm intrigued by the thought process.
  - raphlinus 7y ago
    I'm very happy to expand on my thought process. By "epi Twitter" I mean specifically experts I follow, over a wide range of specialties including disaster preparedness, epidemiology, public health, and related topics. These are among the best people in the field, and are kind enough to share with each other and the rest of us their expertise and thoughts through Twitter. It is awe-inspiring to see. At the same time on Twitter, and at much higher volume, is a torrent of bullshit, with apparently some seeding from active disinformation sources. I try to be very careful to filter this out, though it's not always easy (I find my curation much more effective on desktop web than mobile). Public health sources are sometimes wrong. For example, Ohio's chief public health doctor put out an estimate of 100k cases on 3/12, propagated through official channels including a tweet from the Governor [1], and which #epi Twitter very quickly criticized. Work out for yourself which to trust; among other things, with the CFR we're seeing, if the public health official is right we'd be seeing approximately 1k excess deaths in OH, with a timeframe that would certainly have started emerging by now. This particular thing (ibuprofen) is in the category of "emerging research which could be very important if and when it checks out." So basically I'm trying to be very careful to vet the information I transmit. The pipeline from that to actionable advice can sometimes be infuriatingly slow, which no doubt explains why certain things (especially with an easy-to-understand narrative) jump the queue. I will definitely put this in my resource list as soon as I see trustworthy confirmation. And I am confident that if it actually was valid and important, at least one of the experts I follow would have mentioned it by now. [1]: https://twitter.com/GovMikeDeWine/status/1238177953126604801 https://twitter.com/GovMikeDeWine/status/1238177953126604801
diggan 7y ago
Yeah, was published in Lancet https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/ https://www.thelancet.com/journals/lanres/article/PIIS2213-2...
- raphlinus 7y ago
  That paper is about ACE inhibitors, not NSAIDs, and is specifically about patients with hypertension and diabetes, not the general population. Co-morbidity is apparently a huge driver of deaths, so research on these kinds of interactions is very important. But I think parent comment is a data point of evidence that the general public can't be trusted to interpret research.

searine 7y ago

This isn't clear yet. It is a reasonable assumption based on the biology but not verified.

yread 7y ago

Especially ibuprofen as it can cause water retention exacerbating pneumonia