4 ms·
Has FAH approach solved any other real world problems? Has its findings accelerated understanding of any particular disease or helped significantly in developin
by sunshinerag 7y ago
Has FAH approach solved any other real world problems? Has its findings accelerated understanding of any particular disease or helped significantly in developing a cure?
- adrianN 7y agoHave you checked the website? E.g. https://foldingathome.org/papers-results/ https://foldingathome.org/papers-results/
- atsuzaki 7y agoTheir wiki page lists a handful of them: https://en.wikipedia.org/wiki/Folding%40home#Examples_of_application_in_biomedical_research https://en.wikipedia.org/wiki/Folding%40home#Examples_of_app... Do keep in mind that 1. very few drug candidates make it through drug trials (iirc it's something around 1 in 1000), and 2. these trials takes 10+ years, and FAH has been around for only 19 years. It's very likely that a bunch of its results are in trial right now, and we'd only hear about it 10-20 years in the future
- dekhn 7y agoThe F@H paper I was a coauthor on (https://www.ncbi.nlm.nih.gov/pubmed/24345941 https://www.ncbi.nlm.nih.gov/pubmed/24345941) has been cited by many in pharma. I honestly can't say whether it has directly contributed, but many people have been thankful for this work because it helped establish the concept that proteins aren't super stable rocks, so virtual drug discovery screening can work better if you can simulate the dynamics of a protein (in this case, we simulated a GPCR, which is a common pharma target).