4 ms·

I'm not sure this tidbit is useful when, as far as I can tell, there aren't useful a lot of very useful data on allergies or their prevalence. There are some[1]

I'm not sure this tidbit is useful when, as far as I can tell, there aren't useful a lot of very useful data on allergies or their prevalence. There are some[1] but they may not capture historical trends or useful comparisons between countries, and can otherwise be completely inaccurate unless one looks specifically at oral food challenge response data. So what are you really trying to say? [1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163515/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163515/

ta999999171 7y ago
He's trying to say put your kid in the dirt and feed them fuckin peanuts - couldn't be more clear if you've put a few minutes into the topic.
- dchichkov 7y ago
  I was primarily pointing out - it is a bit of a problem when the industry is a bit too eager to sell color coded pills. And is not too shy of aggressive marketing, like such that did the opioid crisis trick. And is not particularly interested in figuring out the actual problem, if there is no money immediately in sight. I don't know the solution. Not a specialist. Maybe it is connected with microbiome. Wouldn't be surprised that it is broken somehow, maybe even at the level of population. On your comment, maybe. But one probably have to be a bit careful about dirt, there might be contamination with pesticides and pathogens. There's no established research. It is also somewhat known that microbiome and immune system reaches stable state with age.
  - striking 7y ago
    This is more of the reply I was looking for; this seems a little more reasonable. On the one hand, you're not wrong that previously the guidelines for introducing kids to peanuts, especially those with a family history of peanuts, were wrong[1] and that this may be a pretty big reason why this problem is so currently visible especially in the US. (though nobody really knows for sure) That being said, would you trust yourself to isolate peanut allergen, measure it to 600mg, and feed it to your kid? I couldn't do that. Now that some kids have this problem and it's not just going to go away if we cram a peanut down their throats, it's nice that the medical industry has provided a solution. It's unfortunate that it's expensive but this problem is just a problem with the entire industry as it stands in the US. 1: https://www.npr.org/sections/thetwo-way/2017/01/05/508348588/new-guidelines-tell-parents-when-to-introduce-babies-to-peanut-products https://www.npr.org/sections/thetwo-way/2017/01/05/508348588...
    - dchichkov 7y ago
      I think right lines of research are around tweaking the gut microbiome. And the real underlying problem that we are facing is a "diet+environment+herd" problem. With the horizontal bacteria transfer playing major role in it. I don't think it is a good idea to take broken immune system and introduce a known trigger in unknown quantity. And I don't see much difference between serving a bit of diluted peanut butter and a pill like the one that got expedited through FDA as a breakthrough therapy. In my opinion both are pretty much the same level of intervention and both are quite stupid. I'm not a specialist and can be easily wrong here. This is an opinion. The quality of this post is a "random post on the internet" type of thing. The top post content is pretty much citations from the article. And me, not being impressed by the solution and the set of incentives to the industry that had produced that solution.
modzu 7y ago
he's quoting the article; Palforzia actually is peanut powder. so if the drug works, "peanuts" work..
- refurb 7y ago
  The peanut flour in the drug has a standardized amount of allergen. If you want to try to sensitize your highly sensitive child using peanuts you crushed up yourself, hats off to you! Keep an Epipen around!
  - pbhjpbhj 7y ago
    In some countries simple medicines get charged at huge rates. Apparently a £20 epipen is hundreds of $USD in USA, not everyone can afford to pay for medicines in their country.

ta999999171 7y ago

He's trying to say put your kid in the dirt and feed them fuckin peanuts - couldn't be more clear if you've put a few minutes into the topic.

dchichkov 7y ago
I was primarily pointing out - it is a bit of a problem when the industry is a bit too eager to sell color coded pills. And is not too shy of aggressive marketing, like such that did the opioid crisis trick. And is not particularly interested in figuring out the actual problem, if there is no money immediately in sight. I don't know the solution. Not a specialist. Maybe it is connected with microbiome. Wouldn't be surprised that it is broken somehow, maybe even at the level of population. On your comment, maybe. But one probably have to be a bit careful about dirt, there might be contamination with pesticides and pathogens. There's no established research. It is also somewhat known that microbiome and immune system reaches stable state with age.
- striking 7y ago
  This is more of the reply I was looking for; this seems a little more reasonable. On the one hand, you're not wrong that previously the guidelines for introducing kids to peanuts, especially those with a family history of peanuts, were wrong[1] and that this may be a pretty big reason why this problem is so currently visible especially in the US. (though nobody really knows for sure) That being said, would you trust yourself to isolate peanut allergen, measure it to 600mg, and feed it to your kid? I couldn't do that. Now that some kids have this problem and it's not just going to go away if we cram a peanut down their throats, it's nice that the medical industry has provided a solution. It's unfortunate that it's expensive but this problem is just a problem with the entire industry as it stands in the US. 1: https://www.npr.org/sections/thetwo-way/2017/01/05/508348588/new-guidelines-tell-parents-when-to-introduce-babies-to-peanut-products https://www.npr.org/sections/thetwo-way/2017/01/05/508348588...
  - dchichkov 7y ago
    I think right lines of research are around tweaking the gut microbiome. And the real underlying problem that we are facing is a "diet+environment+herd" problem. With the horizontal bacteria transfer playing major role in it. I don't think it is a good idea to take broken immune system and introduce a known trigger in unknown quantity. And I don't see much difference between serving a bit of diluted peanut butter and a pill like the one that got expedited through FDA as a breakthrough therapy. In my opinion both are pretty much the same level of intervention and both are quite stupid. I'm not a specialist and can be easily wrong here. This is an opinion. The quality of this post is a "random post on the internet" type of thing. The top post content is pretty much citations from the article. And me, not being impressed by the solution and the set of incentives to the industry that had produced that solution.

modzu 7y ago

he's quoting the article; Palforzia actually is peanut powder. so if the drug works, "peanuts" work..

refurb 7y ago
The peanut flour in the drug has a standardized amount of allergen. If you want to try to sensitize your highly sensitive child using peanuts you crushed up yourself, hats off to you! Keep an Epipen around!
- pbhjpbhj 7y ago
  In some countries simple medicines get charged at huge rates. Apparently a £20 epipen is hundreds of $USD in USA, not everyone can afford to pay for medicines in their country.