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Consider what happens to your immune system when it detects a foreign particle that it can't get rid of because there's no way to interact with it.

by mark-r 7y ago

XMPPwocky 7y ago
What happens? I'm not an immunologist, and "common sense" certainly doesn't seem like the way to think about the behavior of something as complex as the human immune system.
- Supermancho 7y ago
  The human immune system doesn't need to "interact" with a physical particle. White cells envelope (standard attack) a foreign particle, then dies around them, and the resulting envelope is expelled. Your body is mostly fluid. Internal fluids don't really need complex chemical interactions but the dead white blood cell acts as an effective envelope for transport, by design. eg mucus in your nose when you're sick.
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nate_meurer 7y ago
For the most part, what happens is nothing. PTFE is completely biologically inert, which is why it's commonly used in surgical implants and prosthetics. Only the finest particles (<100 nm) have been established to present a biological hazard, and these are very hard to come by. Ingested PTFE passes right through the digestive system unaltered. You can scrape the non-stick coating off of all your pans and eat it, and there will no detectable fluorinated chemicals in your blood. However, if you heat that nonstick pan above 600 deg F, the decomposition products can easily injure you, and sometimes worse. But even in this case, and main danger does not appear to be microfine PTFE particles, but rather chemical nasties like fluoroacetates. There are many studies on this. One example: https://www.ncbi.nlm.nih.gov/pubmed/11042093 https://www.ncbi.nlm.nih.gov/pubmed/11042093 - "Pulmonary effects induced by ultrafine PTFE particles"
- munk-a 7y ago
  Just to clarify, if a large quantity of PTFE particles was introduced into your blood stream are you stating that wouldn't deprive your cells of oxygen? I think you're making some health related claims and assumptions that may be correct in limited circumstances but haven't been sufficiently studied to come to a good conclusion on.
  - nate_meurer 7y ago
    Umm... yes? Why would PTFE "deprive cells of oxygen"? What cells? What size particles? Do you think they'd block your arteries or something? Why would that be any different than any other material? And how exactly would such particles get into your body? By injection? PTFE is chemically and biologically inert. It's well studied, and has enjoyed extensive medical use inside peoples' bodies for over half a century. I'm aware of no evidence that PTFE in your body is harmful in any form or quantity that is known to actually occur in humans. If you have any evidence to the contrary, I'd love to hear it.
    - munk-a 7y ago
      The process to ensure your cells get enough oxygen is a complex one. When you're exercising heavily certain chemical signals are sent out to ask the heart to increase blood flow to compensate for the high consumption of oxygen - similarly injuries produce stressor signals when the body is damaged and bleeding (since the lowered blood pressure decreases the efficiency of the heart's ability to deliver oxygen) - if an inert chemical was introduced into the blood stream slowly it'd gradually reduce the amount of oxygen carried in blood as it flows through your body by decreasing the proportion of red blood cells per volume, to compensate maybe your heart needs to beat a bit quicker deliver the same amount of oxygen via blood. Keeping your blood clean of impurities is traditionally (mostly) handled by the kidneys, if some PTFE is introduced into the blood stream does PTFE recognize this impurity as a dilution - will it properly filter it out? How efficient is that filtering and how much will it stress your kidneys? Basically, bodies are complex objects - this is what studies are for and long term effects can take time to be detected. I don't have any evidence to the contrary, but I am skeptical of how conclusive the supporting evidence is and would place the onus on proving harmlessness rather than harmfulness.

Consider what happens to your immune system when it detects a foreign particle that it can't get rid of because there's no way to interact with it.

by mark-r 7y ago

Consider what happens to your immune system when it detects a foreign particle that it can't get rid of because there's no way to interact with it.

XMPPwocky 7y ago

What happens? I'm not an immunologist, and "common sense" certainly doesn't seem like the way to think about the behavior of something as complex as the human immune system.

Supermancho 7y ago
The human immune system doesn't need to "interact" with a physical particle. White cells envelope (standard attack) a foreign particle, then dies around them, and the resulting envelope is expelled. Your body is mostly fluid. Internal fluids don't really need complex chemical interactions but the dead white blood cell acts as an effective envelope for transport, by design. eg mucus in your nose when you're sick.
- deleted 7y ago
  [deleted]
deleted 7y ago
[deleted]

nate_meurer 7y ago

For the most part, what happens is nothing. PTFE is completely biologically inert, which is why it's commonly used in surgical implants and prosthetics. Only the finest particles (<100 nm) have been established to present a biological hazard, and these are very hard to come by. Ingested PTFE passes right through the digestive system unaltered. You can scrape the non-stick coating off of all your pans and eat it, and there will no detectable fluorinated chemicals in your blood. However, if you heat that nonstick pan above 600 deg F, the decomposition products can easily injure you, and sometimes worse. But even in this case, and main danger does not appear to be microfine PTFE particles, but rather chemical nasties like fluoroacetates. There are many studies on this. One example: https://www.ncbi.nlm.nih.gov/pubmed/11042093 https://www.ncbi.nlm.nih.gov/pubmed/11042093 - "Pulmonary effects induced by ultrafine PTFE particles"

munk-a 7y ago
Just to clarify, if a large quantity of PTFE particles was introduced into your blood stream are you stating that wouldn't deprive your cells of oxygen? I think you're making some health related claims and assumptions that may be correct in limited circumstances but haven't been sufficiently studied to come to a good conclusion on.
- nate_meurer 7y ago
  Umm... yes? Why would PTFE "deprive cells of oxygen"? What cells? What size particles? Do you think they'd block your arteries or something? Why would that be any different than any other material? And how exactly would such particles get into your body? By injection? PTFE is chemically and biologically inert. It's well studied, and has enjoyed extensive medical use inside peoples' bodies for over half a century. I'm aware of no evidence that PTFE in your body is harmful in any form or quantity that is known to actually occur in humans. If you have any evidence to the contrary, I'd love to hear it.
  - munk-a 7y ago
    The process to ensure your cells get enough oxygen is a complex one. When you're exercising heavily certain chemical signals are sent out to ask the heart to increase blood flow to compensate for the high consumption of oxygen - similarly injuries produce stressor signals when the body is damaged and bleeding (since the lowered blood pressure decreases the efficiency of the heart's ability to deliver oxygen) - if an inert chemical was introduced into the blood stream slowly it'd gradually reduce the amount of oxygen carried in blood as it flows through your body by decreasing the proportion of red blood cells per volume, to compensate maybe your heart needs to beat a bit quicker deliver the same amount of oxygen via blood. Keeping your blood clean of impurities is traditionally (mostly) handled by the kidneys, if some PTFE is introduced into the blood stream does PTFE recognize this impurity as a dilution - will it properly filter it out? How efficient is that filtering and how much will it stress your kidneys? Basically, bodies are complex objects - this is what studies are for and long term effects can take time to be detected. I don't have any evidence to the contrary, but I am skeptical of how conclusive the supporting evidence is and would place the onus on proving harmlessness rather than harmfulness.