4 ms·

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $

Looks interesting, but how could I ever afford to buy ~12 designer drugs which I figure likely cost at least $1-2/day if they are effective? Cost per year is $4K- $8K? I'm guessing I'll wait 20 years until they are off patent?

mkagenius 7y ago
Maybe take once a week, then you will need to wait only 20 * (365 - 52) / 365 years?
chrisco255 7y ago
Not all of these are new drugs. NMN, for example, is a supplement that you can buy now. It's a bit expensive but the price is dropping as it becomes more popular. Others mentioned include HGH, which has been around for decades. Only problem there is that it's a controlled substance so getting a prescription for anti-aging purposes may be difficult.
- simonsaidit 7y ago
  Hgh works wonders used it for about 3 months and got sixpack doing hardly any workout. Lost all excess fat. Got a better sleeping pattern. Its easy to get your hands on online. Problem is that its mad expensive even more so with a prescription as the stuff without you might get was stolen or a cheaper brand.
- LinuxBender 7y ago
  I am not saying there isn't a use case for HGH, but you can increase your own natural HGH production through intermittent fasting, l-glutamine, and cycling up/down a few other molecules. I learned this by mistake, from trying to repair damage to my gut. The weird side effect was quite a bit of muscle development and I don't even work out. On top of that, I dampen mtorc1 with Berberine, Sulforaphane, Myrosinase, TransResveratrol, DIM+Quercertin and that should slow HGH production, but has the opposite effect and increases it. And I second the NMN being expensive. I use about 800mg a day and it is by far the most expensive thing I take.
  - DennisP 7y ago
    I could really use that weird side effect. What other molecules did you cycle up/down?
    - LinuxBender 7y ago
      I owe HN community a blog update on this process and I promise I will do that in the coming couple weeks. I've been a bit busy as of late. When I do, I will add it to my profile. It's not quite as simple as what to take, but also when to take, in what combinations and why. And it probably isn't the most scientific process, so I'm sure I will catch some flak for it.
      - pstuart 7y ago
        It might be worth posting to reddit.com/r/longevity as well. I'm looking forward to it.
  - epicureanideal 7y ago
    It would be great if someone out there could build a simple site to track cheap quality sources of NMN and the progress of price decline over time!
  - ozfive 7y ago
    Just saw this after googling NMN supplement. https://www.scientificamerican.com/article/cancer-research-points-to-key-unknowns-about-popular-antiaging-supplements/ https://www.scientificamerican.com/article/cancer-research-p...
- joncrane 7y ago
  HGH is a wonder drug, but it's tricky. Not only for the expense factor, but like everything else, when you add exogenous hormones, your body stops producing them. So if you supplement with HGH for years or even months, your body stops making it and the ability to produce more may take a very long time to come back. It may never come back. Also, there are many types of tumors that have HGH receptors, and HGH has an even bigger impact on the tumor than it does on the rest of your body. So you're basically supercharging your cancer.
  - simonsaidit 7y ago
    Yes the tumors part was always what scared me about it and why i would not do it again. Its the first time i hear about hgh being able to stop your own production its not something ive found researching the downsides. Its Well know for steroids though.
    - copperx 7y ago
      I don't care how young HGH will make me feel if I'm sacrificing longevity because of increased cancer risk. Cancer is the #1 enemy of longevity.
  - andy_ppp 7y ago
    Probably worth cycling it then but no one is sure of optimal schedules even for fasting, let alone this...
maerF0x0 7y ago
This is my main concern too. That I'll fund the research and then not be able to afford the treatment. something like "You gave $50 a month for 20 yrs to unlock the treatment, but now it costs $10000 and you cannot afford that? Too bad."
melling 7y ago
Medical tourism.
ben_w 7y ago
That sounds cheap compared to the cost of old-age healthcare. For comparison, Alzheimer’s care homes cost ~£1000/week in the UK.
- ksdale 7y ago
  A lot of preventative care just delays old-age care rather than avoiding it entirely. I remember a professor in law school saying that during the big tobacco trials, someone mentioned that people dying younger from smoking meant lower healthcare costs overall, because the major predictor of healthcare costs is age. Basically everyone dies, and the older you are when you die, the more expensive it will be. Obviously that's not a good reason to die early, but preventative care is mostly good for quality of life, rather than from a financial perspective.
  - asdff 7y ago
    dying early while straining the system tasked with treating your lung cancer and emphysema might not actually save more money
    - ksdale 7y ago
      Most people don't die from old age and nothing else, though. If someone doesn't die from lung cancer, they're most likely going to die from some other kind of cancer, heart disease, Alzheimer's, diabetes, or some kind of organ failure, none of which are exactly inexpensive to die from (barring very sudden death from a heart attack or stroke).
reitzensteinm 7y ago
Living longer with good health means significantly extending the most lucrative years of your life. Although it sounds trite, the cost should correctly be thought of as an investment. (Assuming they actually work. I'm skeptical.)
- crystaldev 7y ago
  Maybe it's that I'm mid-career and burnt out, but the idea of getting to be a draft animal for an extra decade is utterly unappealing.
  - naasking 7y ago
    Agreed, but keep in mind rejuvenation means it'd be a lot harder to get burnt out and easier to recover.
    - AstralStorm 7y ago
      Feeling better about it does not change the fact that you're a draft animal. (Not doing what you actually want to.)

mkagenius 7y ago

Maybe take once a week, then you will need to wait only 20 * (365 - 52) / 365 years?

chrisco255 7y ago

Not all of these are new drugs. NMN, for example, is a supplement that you can buy now. It's a bit expensive but the price is dropping as it becomes more popular. Others mentioned include HGH, which has been around for decades. Only problem there is that it's a controlled substance so getting a prescription for anti-aging purposes may be difficult.

simonsaidit 7y ago
Hgh works wonders used it for about 3 months and got sixpack doing hardly any workout. Lost all excess fat. Got a better sleeping pattern. Its easy to get your hands on online. Problem is that its mad expensive even more so with a prescription as the stuff without you might get was stolen or a cheaper brand.
LinuxBender 7y ago
I am not saying there isn't a use case for HGH, but you can increase your own natural HGH production through intermittent fasting, l-glutamine, and cycling up/down a few other molecules. I learned this by mistake, from trying to repair damage to my gut. The weird side effect was quite a bit of muscle development and I don't even work out. On top of that, I dampen mtorc1 with Berberine, Sulforaphane, Myrosinase, TransResveratrol, DIM+Quercertin and that should slow HGH production, but has the opposite effect and increases it. And I second the NMN being expensive. I use about 800mg a day and it is by far the most expensive thing I take.
- DennisP 7y ago
  I could really use that weird side effect. What other molecules did you cycle up/down?
  - LinuxBender 7y ago
    I owe HN community a blog update on this process and I promise I will do that in the coming couple weeks. I've been a bit busy as of late. When I do, I will add it to my profile. It's not quite as simple as what to take, but also when to take, in what combinations and why. And it probably isn't the most scientific process, so I'm sure I will catch some flak for it.
    - pstuart 7y ago
      It might be worth posting to reddit.com/r/longevity as well. I'm looking forward to it.
- epicureanideal 7y ago
  It would be great if someone out there could build a simple site to track cheap quality sources of NMN and the progress of price decline over time!
- ozfive 7y ago
  Just saw this after googling NMN supplement. https://www.scientificamerican.com/article/cancer-research-points-to-key-unknowns-about-popular-antiaging-supplements/ https://www.scientificamerican.com/article/cancer-research-p...
joncrane 7y ago
HGH is a wonder drug, but it's tricky. Not only for the expense factor, but like everything else, when you add exogenous hormones, your body stops producing them. So if you supplement with HGH for years or even months, your body stops making it and the ability to produce more may take a very long time to come back. It may never come back. Also, there are many types of tumors that have HGH receptors, and HGH has an even bigger impact on the tumor than it does on the rest of your body. So you're basically supercharging your cancer.
- simonsaidit 7y ago
  Yes the tumors part was always what scared me about it and why i would not do it again. Its the first time i hear about hgh being able to stop your own production its not something ive found researching the downsides. Its Well know for steroids though.
  - copperx 7y ago
    I don't care how young HGH will make me feel if I'm sacrificing longevity because of increased cancer risk. Cancer is the #1 enemy of longevity.
- andy_ppp 7y ago
  Probably worth cycling it then but no one is sure of optimal schedules even for fasting, let alone this...

maerF0x0 7y ago

This is my main concern too. That I'll fund the research and then not be able to afford the treatment. something like "You gave $50 a month for 20 yrs to unlock the treatment, but now it costs $10000 and you cannot afford that? Too bad."

melling 7y ago

Medical tourism.

ben_w 7y ago

That sounds cheap compared to the cost of old-age healthcare. For comparison, Alzheimer’s care homes cost ~£1000/week in the UK.

ksdale 7y ago
A lot of preventative care just delays old-age care rather than avoiding it entirely. I remember a professor in law school saying that during the big tobacco trials, someone mentioned that people dying younger from smoking meant lower healthcare costs overall, because the major predictor of healthcare costs is age. Basically everyone dies, and the older you are when you die, the more expensive it will be. Obviously that's not a good reason to die early, but preventative care is mostly good for quality of life, rather than from a financial perspective.
- asdff 7y ago
  dying early while straining the system tasked with treating your lung cancer and emphysema might not actually save more money
  - ksdale 7y ago
    Most people don't die from old age and nothing else, though. If someone doesn't die from lung cancer, they're most likely going to die from some other kind of cancer, heart disease, Alzheimer's, diabetes, or some kind of organ failure, none of which are exactly inexpensive to die from (barring very sudden death from a heart attack or stroke).

reitzensteinm 7y ago

Living longer with good health means significantly extending the most lucrative years of your life. Although it sounds trite, the cost should correctly be thought of as an investment. (Assuming they actually work. I'm skeptical.)

crystaldev 7y ago
Maybe it's that I'm mid-career and burnt out, but the idea of getting to be a draft animal for an extra decade is utterly unappealing.
- naasking 7y ago
  Agreed, but keep in mind rejuvenation means it'd be a lot harder to get burnt out and easier to recover.
  - AstralStorm 7y ago
    Feeling better about it does not change the fact that you're a draft animal. (Not doing what you actually want to.)