It's all a matter of degree. Exploitation vs exploration in search theory. How many failed clinical trials for amyloid reducing drugs does it take to see a sig

It's all a matter of degree. Exploitation vs exploration in search theory. How many failed clinical trials for amyloid reducing drugs does it take to see a significant possibility that we might need to explore other ideas? People will happily invest other people's money in trials that will likely fail if it's the leading academic theory since they can shift the blame (lack of skin in the game). Academics will have built careers on amyloid research and so will destroy opposition, subconsciously controlled by their egos looking to protect themselves. The incentives are not aligned to use the best exploitation, exploration ratio that might be used in the ideal case but instead heavily weighted towards exploitation ignoring negative results from clinical trials for extended periods of time.