4 ms·
Black boxed. Lactic acidosis.
by throwaway5752 7y ago
Black boxed. Lactic acidosis.
- NotSammyHagar 7y agoPlease elaborate on both sentences, I don't understand.
- Scoundreller 7y agoSee my above post. There was fear that metformin causes lactic acidosis because its predecessor compound did. But the evidence doesn't support that. Black box warning: Some drug regulators put alerts in a black box on their packaging. Unfortunately, these same regulators don't revisit these warnings, leading to 'alert fatigue'. And with non-metformin therapies being far more profitable, the push to get rid of that unnecessary warning isn't there.
- Scoundreller 7y ago> Lactic acidosis. That's debunked hysteria leftover from its predecessor compound. We've been giving metformin long enough to see that it isn't causing lactic acidosis. > Pooled data from 347 comparative trials and cohort studies revealed no cases of fatal or nonfatal lactic acidosis in 70,490 patient-years of metformin use or in 55,451 patients-years in the non-metformin group. > There was no difference in lactate levels, either as mean treatment levels or as a net change from baseline, for metformin compared to non-metformin therapies. https://www.ncbi.nlm.nih.gov/pubmed/20393934 https://www.ncbi.nlm.nih.gov/pubmed/20393934 In other words, you may find a few case reports of patients taking metformin having LA, but that's because you can have LA without metformin.