3 ms·

For a blood pressure medication, 1 in 8,000 is not a small risk. Serzone, an antidepressant, has a similar risk rate for inducing liver failure, and was taken o

For a blood pressure medication, 1 in 8,000 is not a small risk. Serzone, an antidepressant, has a similar risk rate for inducing liver failure, and was taken off the market.

strainer 7y ago
It demonstrates a not insignificant risk but it would be from taking the most contaminated batch of the product for 4 years. If a patient took the most contaminated sample found for 4 years there would be a 1/8000 chance of cancer from it. It illustrates this level of contamination should be a concern but it seems unlikely anyone could be exposed continuously to this highest detected level.
Scoundreller 7y ago
For nefazodone, we had other antidepressants (so why take the risk?), and it was only taken off the market when it went generic (lol). For BP medication, hopefully at least 1 in 100 recipients are benefitting from it. Probably more like 1 in 10. Overall, don't stop taking it. Reducing the cancer risk is possible and feasible in this case without changing therapy. We'll probably see further testing of APIs and validation of synthetic route changes in the future because of it.