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They likely got a bad batch of THC cartridges, there's a ton of black market ones going around all over, with who knows what in them. Millions of people use ni
by buttcoinslol 7y ago
They likely got a bad batch of THC cartridges, there's a ton of black market ones going around all over, with who knows what in them.
Millions of people use nicotine vaporizers daily with no ill effects.
- leggomylibro 7y agoYeah, a local cluster of ~8-20 cases and the patients say they were using 'THC' cartridges in a state where it's illegal? People were putting synthetic cannabinoids in e-juice over a decade ago, and I'd be surprised if there wasn't still a market for it. I'd also be surprised if the actual chemicals being used haven't evolved to keep up with regulations - at this point they'd probably be dozens of analogues away from what was presented in the original Huffman papers, huh? I think it's probably a very bad idea to knowingly use that sort of thing, but I guess the underground market might not have very well-regulated labeling standards.
- JamesBarney 7y agoYeah the clustering makes me think they got a tainted cartridge as opposed to it being an inherent risk of vaping.
- buttcoinslol 7y agoYes, from own experiences, the cheap carts [dank/mario cart] which are black market only labels use thc analogues while the ones that make it here that are sold in dispensaries are generally legit [rove/tko] From what I've read about opiate analogues, whatever thc analogues they're using ~15 years after the Huffman paper are far removed from their original state. I can also confirm there is a tremendous demand for thc carts in non-legal states.
- SynthCann 7y agoVery interesting to see JWH discussed on HN. This stuff was BIGGG about a decade ago, and then I stopped hearing about it. It's crazy to see they are still playing the game of cat and mouse with these analogues, and even getting them into the black market carts. I have medical so thankfully I don't need to mess with the black market at this point. I would _highly_ advise against using any synthetic cannabinoids.
- tempguy9999 7y ago> I would _highly_ advise against using any synthetic cannabinoids. Any specific reasons to say this? Medical knowledge, personal experience or other? I did have one experience with a synthetic cannabinoid and it was very bad indeed, took me days to recover. FYI. I'd not rule out trying it again but with great care. Though now it's illegal in the UK, so prob won't happen.
- sterlind 7y agoI remember there being a number of deaths from some cannabinoids, but after doing some research I can't confirm. This is what I found: AMB-FUBINACA caused a "zombie outbreak" which sent 33 people to the hospital in Brooklyn: https://www.nytimes.com/2016/12/14/nyregion/zombielike-state-was-caused-by-synthetic-marijuana.html https://www.nytimes.com/2016/12/14/nyregion/zombielike-state... Anecdotally, AM-2201 seems to cause enlarged liver and other health problems with long-term use: https://www.erowid.org/experiences/exp.php?ID=95702 https://www.erowid.org/experiences/exp.php?ID=95702 I remember CP-55,940 and WIN-55,212 having serious side effects but I couldn't find information..
- tempguy9999 7y agoComprehensive answer. I particularly appreciate you made it clear what you couldn't verify, or what was anecdotal. I wish I could upvote it twice for that alone.
- SargeZT 7y agoMany of them are full agonists on the cannabanoid receptors, which leads to GABA levels that are dangerously low when the receptors are saturated. THC proper lowers GABA somewhat, but not nearly as much. They've lead to seizures and have been linked to at least a few deaths.
- WalterSear 7y agoThey aren't. Parent is misinformed.
- WalterSear 7y agoNot analogs. The analogs can kill you via overdose. That's not happening here.
- jdc 7y agoNot disputing, but do you have a source handy?
- deleted 7y ago[deleted]
- WalterSear 7y agoNatural cannabinoids only have a limited affinity for the endocannabinoid synapse. >Studies have found that these compounds tend to activate the CB1 receptor to a greater degree than does THC, suggesting that synthetic marijuana compounds have the ability to induce far more intense effects than marijuana, according to the review. https://www.livescience.com/57747-synthetic-marijuana-risks.html https://www.livescience.com/57747-synthetic-marijuana-risks.... >Much of our understanding of cannabinoid tolerance, dependence and withdrawal has been based on studies involving Δ9-THC, a relatively weak partial agonist at CB1 and CB2 receptors. However, the SCBs commonly found in quasi-legal commercial products such as K2 and Spice are typically full cannabinoid receptor agonists. Importantly, a drug's efficacy determines how “powerful” its maximal effects may be in biological systems. A low efficacy cannabinoid like Δ9-THC will have a less pronounced maximal effect than a higher efficacy cannabinoid, such as the SCBs present in commercial products, and this difference in maximal effects cannot be overcome simply by increasing the dose of Δ9-THC. In other words, no amount of Δ9-THC can stimulate cannabinoid receptors to the same degree as the SCBs currently emerging as drugs of abuse. This has left researchers working with these high efficacy SCBs in the unusual position of having to determine whether their effects are related to the unprecedented degree of cannabinoid receptor stimulation elicited by these compounds, or whether they are produced by interactions with other, non-cannabinoid receptor systems. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582439/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582439/
- Jarwain 7y agoI'd imagine that would depend on the analogue
- doctorpangloss 7y ago> Millions of people use nicotine vaporizers daily with no ill effects. The movement against tobacco hasn't failed, but it is in the trough of its cycle.
- Hasknewbie 7y agoA recent study here in Europe as found that some low-quality CBD e-liquids contain traces of solvent (used to extract said CBD) that are above safety level and may trigger adverse reaction in vapers. I assume THC e-liquid goes through the same sort of process and may have the same issue.
- tapland 7y agoI would love it if you had a link to that study. A relative of mine is on the lookout for CBD oils and I said I'd help find what there is.
- Hasknewbie 7y agoI don't have a direct link to the study, but this is from the BBC (https://www.bbc.com/news/health-48950483 https://www.bbc.com/news/health-48950483): "The researchers also found the presence in seven products of the solvent dichloromethane, which can cause wheezing and shortness of breath, at levels above food safety limits."
- Scoundreller 7y agoAre food safety limits the appropriate limit for something that will be largely exhaled?
- buttcoinslol 7y agoYes, residual solvents are possible with the THC extraction process. I prefer to use THC concentrates extracted with CO2 to avoid inhaling residual solvents.
- robocat 7y agoCan you tell only CO2 was used?
- whenchamenia 7y agoCo2 iirc is a physical extraction, like bubble hash, while this is concerning solvent hash, a different product. The correct way to extract solvents is under vacuum.
- scruple 7y agoThere's an Instagram user who independently tests, meaning he pays to have an independent lab test the samples, (THC) carts for pesticides and solvents and posts the results for all to see. He's a hero, as far as I'm concerned. There's so much shit in these cartridges. They are concentrated, so pesticides used during growth can also be concentrated in the cartridges. It's completely absurd to me that this stuff isn't more regulated.
- brokenmachine 7y ago100% agree but every time anyone comments that vaping should be regulated, the wolves come out shouting at the top of their lungs how safe vaping is, and how much better vaping is than smoking, and saying that you're basically forcing people to keep smoking by doing anything to regulate vaping.