10 ms·

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that us

by oblib 7y ago

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that used magnesium glycinate successfully as a treatment and it has worked wonders for her. She takes a 300 mg tab and in 20 minutes she's completely calmed down. It only lasts for about four hours but the effect is amazing. The downside is it can cause diarrhea when taken every four hours but if she eats a couple bananas a day (for the fiber) that's not an issue. She's also been experiencing auditory hallucinations (hearing voices) and I found a study that showed CBD helping with that, so I got her to start taking that too, and it's worked amazingly well for her to deal with that. If it also helps with anxiety that's all the better for her. Her birth mother was diagnosed as schizophrenic about a year after my daughter was born so my daughter is probably dealing with that too, but the drug the doctors gave her mother 35 years ago (haloperidol) didn't work near as well as the magnesium/CBD my daughter is taking and the side effects were vicious. That shit turned her mother into a slobbering zombie. I took my daughter to a mental health facility yesterday to get evaluated and we told them she was taking the magnesium glycinate for anxiety and CBD for "the voices" and they didn't tell her to stop or prescribe any pharmaceutical drugs for her. They just told her to start "Mindful therapy" sessions with a doctor there. I've been smoking herb for about 46 years pretty much daily and have never felt anxious, but I've known a few people who have. I've attributed that to all the reefer madness that's been shoved at us for so long, but it could be it affects some people differently than I and all my herb smoking friends. I don't feel any effects at all from taking CBD, but I don't have any of the symptoms it's used to treat effectively and it could be I have plenty enough in my system from the weed I smoke anyway.

chrstphrhrt 7y ago
Very interesting, I have noticed a major (albeit fun) experience of mania from CBD, followed by extreme rebound anxiety after cessation following a period of taking it for a while. THC-heavy strains on the other hand, seem to have no bad effects.
srik 7y ago
IANAD. The glycerinate does have a better absorption rate but and taking over 300mg a day regularly apparently has the potential for side effects (beside those bowel effects) - at least that's what I've gathered looking into Mg supplements previously.
- oblib 7y ago
  Yes, it's a trade off and she needs to adjust the doses down if she can. Right now she's in shit shape mentally after being ditched by her fiancé so hopefully time will help her get over that, but truly amazing how well and quickly the magnesium glycinate helps calm her down. Physically she's as strong as can be. She's a level II Crossfit trainer and stronger than me. We're going try transitioning towards getting the magnesium from food sources if we can get her over this hump. She eats healthy, but she's obviously not getting enough magnesium and burning it up quickly right now.
  - 78dfshj4 7y ago
    You can use Mag Oil as another way to get Mg into the body. Its basically Magnesium Sulphate aka Epsom Salts mixed with water and rubbed on the skin. If its really concentrated it will sting the skin, but dilute to reduce the stinging effect. Alternatively soak in a bath with Magnesium Sulphate. https://www.epsomsaltcouncil.org/wp-content/uploads/2015/10/report_on_absorption_of_magnesium_sulfate.pdf https://www.epsomsaltcouncil.org/wp-content/uploads/2015/10/... Any sulphate can be absorbed through the skin, so soaking in copper sulphate will get more copper into the body which is useful for all types of Collagen. Copper will also make smokers feel like they are smoking their very first cigarette, ie they will feel nauseous if they smoke within 30mins of taking a copper supplement. I wouldnt advise applying copper sulphate directly onto the skin though as it will debride the skin and is now only used by the US Military for cleaning extreme wounds. Magnesium irritates the lower bowel hence the diarrhea, so if taken orally, its better to take little and often through the day rather than one big supplement for a day, and always take after eating because tablets breakdown in the gut and get into the blood stream quickly. Magnesium is also used to make ATP (Adenosine triphosphate) which helps provide cellular energy so being superfit, her demands for Mg will be higher than a sedate person. Taking Potassium also helps the cells take up glucose, amino acids and other nutrients including magnesium whilst sodium makes the cells take up just water, so in a way sodium starves cells at a cellular level, which could help contribute to a variety of problems including anxiety. To get your daily potassium intake of 4.7grams, you would need to eat 11 large banana's a day. One sign you are deficient in Potassium is you crave sugary foods after eating, but if you supplement around >2g with potassium (chloride/bicarbonate) your sugar cravings will go.
agumonkey 7y ago
What brand and kind of CBD do you use ?
- oblib 7y ago
  It's high CBD content oil that's got a private label brand. I'm not familiar with the supplier, but the supplement store we buy it from is locally owned and very reputable. My daughter works for them on occasion. They also sell CBD buds and she says she likes those better than the oil.
  - agumonkey 7y ago
    So it's under the tongue intake ? or is it vaporized and inhaled ? Does she feel other improvements as well ? eating, sleeping or else ?
clarityPhone 7y ago
I get anxiety when I smoke and am way too young to attribute it to any sort of “reeder madness” - so it’s definitely a thing. I don’t smoke super often, and don’t always get anxiety when I do, but it definitely gave me terrible anxiety when I was younger. If anyone else gets anxiety when they smoke, I recommend smoking sativa instead of indica (nicknamed “in da couch” because of its anxiety effects). I was given the tip from a stoner friend, and it’s fsirly true in my experience.
- instakill 7y ago
  1) you got the 2 mixed up, it's indica that's the in-da-couch. Sativa is the brain-high. 2) there's little evidence to prove that sativa/indica strains affect your high. The curing, drying, growing of each individual plant alters the THC-CBD-CBG ratios way more than strain or species.
  - OldSchoolJohnny 7y ago
    Point number 2 is utterly untrue as any experienced cannabis enthusiast could tell you. Even if people don't know the strain or what the effects are it's pretty reliable that it will either energize them or send them to sleep.
    - leshow 7y ago
      It's not untrue, there is no definition genetically of what a pure sativa/indica strain even is, see my other comment here.
      - thedaemon 7y ago
        What they were saying is anyone with experience in cannabis can tell you after a few minute of smoking if it's sativa or indica. Doesn't matter if there is no genetic definition, there are obvious differences.
        leshow 7y ago
intricatedetail 7y ago
People take cannabis to help them manage the effects of schizophrenia but corrupt media used to play it other way around. Cannabis causes schizophrenia! If there was justice in this world, then all the editors allowing this should rot in jail.
- ejolto 7y ago
  Dude. CBD is antipsychotic[1] and thus might help people with schizophrenia. THC is psychoactive [2] and should probably be avoided by people with schizophrenia. [1] https://www.ncbi.nlm.nih.gov/pubmed/22716160 https://www.ncbi.nlm.nih.gov/pubmed/22716160 [2] https://www.ncbi.nlm.nih.gov/pubmed/28492950 https://www.ncbi.nlm.nih.gov/pubmed/28492950
  - awelkie 7y ago
    I think that's what the poster is saying. I believe "Cannabis causes schizophrenia!" should be in quotes.
    - kdmccormick 7y ago
      Yes, but the replier is saying that THC, the primary active compound in Cannabis, can in fact worsen some of the symptoms of schizophrenia. As someone with Type I Bipolar, which has many similarities to schizophrenia, I agree that this is often the case.
      - ejolto 7y ago
        This is exactly what I meant. Thanks for sharing your experience.
      - intricatedetail 7y ago
        That's why it should be legal so people who need it won't have to fiddle with the dealers. Obviously big pharma pays a lot so that won't happen.
JamesBarney 7y ago
Just a heads up. The glycine(of the glycinate) might be helping just as much as the magnesium. Glycine is relaxing and theorized to help with schizophrenia. (through nmda signalling) If you're interest in other supplements that have preliminary evidence for helping with schizophrenia are bacopa and sodium benzoate are maybe worth a try.[0][1] - Obviously talk to your doctor about it. https://www.ncbi.nlm.nih.gov/pubmed/29397899 https://www.ncbi.nlm.nih.gov/pubmed/29397899 https://www.ncbi.nlm.nih.gov/pubmed/?term=bacopa+schizophrenia https://www.ncbi.nlm.nih.gov/pubmed/?term=bacopa+schizophren...
- amelius 7y ago
  > sodium benzoate Note that in combination with vitamin C, sodium benzoate may form benzene, which is toxic. But perhaps this is only relevant if you store them together, and at higher temperatures (?) https://en.wikipedia.org/wiki/Sodium_benzoate#Association_with_benzene_in_soft_drinks https://en.wikipedia.org/wiki/Sodium_benzoate#Association_wi...
jokowueu 7y ago
I'm am glad you are helping your daughter thought this . This disease is such a cruel thing to have . I would like to offer some extra info . Since you are looking for OTC . Both NAC and SACROSINE have a lot of great research when it comes to schezophrenia. It seems to work for some but not others.also new research into TMG (betaine glycine) is also interesting There is also a new drug on the horizon that doesn't work on the dopamine receptors and has much less side effects than what's currently SEP-363856 helps treat negative symptoms of schizophrenia such as Inability to experience pleasure, Lack of interest in relationships, Lack of motivation. 5HT1A and taar1 agonist https://www.medscape.com/viewarticle/913348 https://www.medscape.com/viewarticle/913348 MIN-101 - a ~20% BDNF increase. Treats negative symptoms of schizophrenia. 5HT2A and sigma2 receptor antagonist. Min-101 has a targeted release of 2021/2022. After they have completed their 12 week phase 3 trial, they will do a 36 week phase 4 trial. SEP, should also be available sometime in those two years as well. Hope your daughter finds peace
- raducu 7y ago
  I have a mutation which results in impaired BDNF and I do suffer from anxiety; so far buspirone seems to work, but I was considering SEMAX/SELANK for the BDNF increase, do you know anything about that?
  - amvalo 7y ago
    I can tell you it'll make your hair fall out. And maybe make you 20% less anxious/more focused, but honestly it's hard to say... actually, in retrospect I never experienced acute anxiety when I was experimenting with it. Certainly worth a shot.
    - raducu 7y ago
      Does the hair come back after you stop using it? I already have moderate male pattern baldness :) 20% seems ok to me, buspirone is not that great either, but I never experienced panic attacks while on it(actually I only experienced panic attacks while on stimulants), and if I had another option like SELANK/SEMAX with the BDNF boosting bonus, that would be great. I'll give them a shot.
AlexanderNull 7y ago
+1 for Mg. I prefer the citrate salt as I find it faster acting and doesn't give me the same digestive issues, but it's so damned effective for general anxiety I even keep a bottle in my desk at work!
hnick 7y ago
I tend to worry a lot and it's fine during the day, but it really amps up at bedtime and I lie awake with racing thoughts. It sounds worth trying the magnesium glycinate (at least for a week) - from what you say taking it around half an hour before bed will let me know if it helps or not? For the record I've tried melatonin etc - the issue is NOT being tired or even sleepy. My brain just refuses to shut off, to the point where I've started seeing things while awake, when one part starts dreaming and the other refuses to. This usually results in me jumping awake with an extra load of adrenaline to delay my sleep.

by oblib 7y ago

chrstphrhrt 7y ago

Very interesting, I have noticed a major (albeit fun) experience of mania from CBD, followed by extreme rebound anxiety after cessation following a period of taking it for a while. THC-heavy strains on the other hand, seem to have no bad effects.

srik 7y ago

IANAD. The glycerinate does have a better absorption rate but and taking over 300mg a day regularly apparently has the potential for side effects (beside those bowel effects) - at least that's what I've gathered looking into Mg supplements previously.

oblib 7y ago
Yes, it's a trade off and she needs to adjust the doses down if she can. Right now she's in shit shape mentally after being ditched by her fiancé so hopefully time will help her get over that, but truly amazing how well and quickly the magnesium glycinate helps calm her down. Physically she's as strong as can be. She's a level II Crossfit trainer and stronger than me. We're going try transitioning towards getting the magnesium from food sources if we can get her over this hump. She eats healthy, but she's obviously not getting enough magnesium and burning it up quickly right now.
- 78dfshj4 7y ago
  You can use Mag Oil as another way to get Mg into the body. Its basically Magnesium Sulphate aka Epsom Salts mixed with water and rubbed on the skin. If its really concentrated it will sting the skin, but dilute to reduce the stinging effect. Alternatively soak in a bath with Magnesium Sulphate. https://www.epsomsaltcouncil.org/wp-content/uploads/2015/10/report_on_absorption_of_magnesium_sulfate.pdf https://www.epsomsaltcouncil.org/wp-content/uploads/2015/10/... Any sulphate can be absorbed through the skin, so soaking in copper sulphate will get more copper into the body which is useful for all types of Collagen. Copper will also make smokers feel like they are smoking their very first cigarette, ie they will feel nauseous if they smoke within 30mins of taking a copper supplement. I wouldnt advise applying copper sulphate directly onto the skin though as it will debride the skin and is now only used by the US Military for cleaning extreme wounds. Magnesium irritates the lower bowel hence the diarrhea, so if taken orally, its better to take little and often through the day rather than one big supplement for a day, and always take after eating because tablets breakdown in the gut and get into the blood stream quickly. Magnesium is also used to make ATP (Adenosine triphosphate) which helps provide cellular energy so being superfit, her demands for Mg will be higher than a sedate person. Taking Potassium also helps the cells take up glucose, amino acids and other nutrients including magnesium whilst sodium makes the cells take up just water, so in a way sodium starves cells at a cellular level, which could help contribute to a variety of problems including anxiety. To get your daily potassium intake of 4.7grams, you would need to eat 11 large banana's a day. One sign you are deficient in Potassium is you crave sugary foods after eating, but if you supplement around >2g with potassium (chloride/bicarbonate) your sugar cravings will go.

agumonkey 7y ago

What brand and kind of CBD do you use ?

oblib 7y ago
It's high CBD content oil that's got a private label brand. I'm not familiar with the supplier, but the supplement store we buy it from is locally owned and very reputable. My daughter works for them on occasion. They also sell CBD buds and she says she likes those better than the oil.
- agumonkey 7y ago
  So it's under the tongue intake ? or is it vaporized and inhaled ? Does she feel other improvements as well ? eating, sleeping or else ?

clarityPhone 7y ago

I get anxiety when I smoke and am way too young to attribute it to any sort of “reeder madness” - so it’s definitely a thing. I don’t smoke super often, and don’t always get anxiety when I do, but it definitely gave me terrible anxiety when I was younger. If anyone else gets anxiety when they smoke, I recommend smoking sativa instead of indica (nicknamed “in da couch” because of its anxiety effects). I was given the tip from a stoner friend, and it’s fsirly true in my experience.

instakill 7y ago
1) you got the 2 mixed up, it's indica that's the in-da-couch. Sativa is the brain-high. 2) there's little evidence to prove that sativa/indica strains affect your high. The curing, drying, growing of each individual plant alters the THC-CBD-CBG ratios way more than strain or species.
- OldSchoolJohnny 7y ago
  Point number 2 is utterly untrue as any experienced cannabis enthusiast could tell you. Even if people don't know the strain or what the effects are it's pretty reliable that it will either energize them or send them to sleep.
  - leshow 7y ago
    It's not untrue, there is no definition genetically of what a pure sativa/indica strain even is, see my other comment here.
    - thedaemon 7y ago
      What they were saying is anyone with experience in cannabis can tell you after a few minute of smoking if it's sativa or indica. Doesn't matter if there is no genetic definition, there are obvious differences.
      - leshow 7y ago

intricatedetail 7y ago

People take cannabis to help them manage the effects of schizophrenia but corrupt media used to play it other way around. Cannabis causes schizophrenia! If there was justice in this world, then all the editors allowing this should rot in jail.

ejolto 7y ago
Dude. CBD is antipsychotic[1] and thus might help people with schizophrenia. THC is psychoactive [2] and should probably be avoided by people with schizophrenia. [1] https://www.ncbi.nlm.nih.gov/pubmed/22716160 https://www.ncbi.nlm.nih.gov/pubmed/22716160 [2] https://www.ncbi.nlm.nih.gov/pubmed/28492950 https://www.ncbi.nlm.nih.gov/pubmed/28492950
- awelkie 7y ago
  I think that's what the poster is saying. I believe "Cannabis causes schizophrenia!" should be in quotes.
  - kdmccormick 7y ago
    Yes, but the replier is saying that THC, the primary active compound in Cannabis, can in fact worsen some of the symptoms of schizophrenia. As someone with Type I Bipolar, which has many similarities to schizophrenia, I agree that this is often the case.
    - ejolto 7y ago
      This is exactly what I meant. Thanks for sharing your experience.
    - intricatedetail 7y ago
      That's why it should be legal so people who need it won't have to fiddle with the dealers. Obviously big pharma pays a lot so that won't happen.

JamesBarney 7y ago

Just a heads up. The glycine(of the glycinate) might be helping just as much as the magnesium. Glycine is relaxing and theorized to help with schizophrenia. (through nmda signalling) If you're interest in other supplements that have preliminary evidence for helping with schizophrenia are bacopa and sodium benzoate are maybe worth a try.[0][1] - Obviously talk to your doctor about it. https://www.ncbi.nlm.nih.gov/pubmed/29397899 https://www.ncbi.nlm.nih.gov/pubmed/29397899 https://www.ncbi.nlm.nih.gov/pubmed/?term=bacopa+schizophrenia https://www.ncbi.nlm.nih.gov/pubmed/?term=bacopa+schizophren...

amelius 7y ago
> sodium benzoate Note that in combination with vitamin C, sodium benzoate may form benzene, which is toxic. But perhaps this is only relevant if you store them together, and at higher temperatures (?) https://en.wikipedia.org/wiki/Sodium_benzoate#Association_with_benzene_in_soft_drinks https://en.wikipedia.org/wiki/Sodium_benzoate#Association_wi...

jokowueu 7y ago

I'm am glad you are helping your daughter thought this . This disease is such a cruel thing to have . I would like to offer some extra info . Since you are looking for OTC . Both NAC and SACROSINE have a lot of great research when it comes to schezophrenia. It seems to work for some but not others.also new research into TMG (betaine glycine) is also interesting There is also a new drug on the horizon that doesn't work on the dopamine receptors and has much less side effects than what's currently SEP-363856 helps treat negative symptoms of schizophrenia such as Inability to experience pleasure, Lack of interest in relationships, Lack of motivation. 5HT1A and taar1 agonist https://www.medscape.com/viewarticle/913348 https://www.medscape.com/viewarticle/913348 MIN-101 - a ~20% BDNF increase. Treats negative symptoms of schizophrenia. 5HT2A and sigma2 receptor antagonist. Min-101 has a targeted release of 2021/2022. After they have completed their 12 week phase 3 trial, they will do a 36 week phase 4 trial. SEP, should also be available sometime in those two years as well. Hope your daughter finds peace

raducu 7y ago
I have a mutation which results in impaired BDNF and I do suffer from anxiety; so far buspirone seems to work, but I was considering SEMAX/SELANK for the BDNF increase, do you know anything about that?
- amvalo 7y ago
  I can tell you it'll make your hair fall out. And maybe make you 20% less anxious/more focused, but honestly it's hard to say... actually, in retrospect I never experienced acute anxiety when I was experimenting with it. Certainly worth a shot.
  - raducu 7y ago
    Does the hair come back after you stop using it? I already have moderate male pattern baldness :) 20% seems ok to me, buspirone is not that great either, but I never experienced panic attacks while on it(actually I only experienced panic attacks while on stimulants), and if I had another option like SELANK/SEMAX with the BDNF boosting bonus, that would be great. I'll give them a shot.

AlexanderNull 7y ago

+1 for Mg. I prefer the citrate salt as I find it faster acting and doesn't give me the same digestive issues, but it's so damned effective for general anxiety I even keep a bottle in my desk at work!

hnick 7y ago

I tend to worry a lot and it's fine during the day, but it really amps up at bedtime and I lie awake with racing thoughts. It sounds worth trying the magnesium glycinate (at least for a week) - from what you say taking it around half an hour before bed will let me know if it helps or not? For the record I've tried melatonin etc - the issue is NOT being tired or even sleepy. My brain just refuses to shut off, to the point where I've started seeing things while awake, when one part starts dreaming and the other refuses to. This usually results in me jumping awake with an extra load of adrenaline to delay my sleep.