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How to live forever: meet the extreme life-extensionists
- clouddrover 7y ago> Gerontologists are not hoping to end death, he says. Instead, “We’re interested in people not getting sick when they get old.” Yes, an increased healthspan is a better initial goal than an increased lifespan.
- raducu 7y agoFunny because there's bible psalm (psalm 90 in the west, 89 in the eastern orthodoxy) stating the lifespan of humans is 70, above that and all you get is pain and tiredness (I think the western translations are stating that all life is like that).
- haylel 7y agoI'm not christian so I don't know the topic well but what about the people who lived 900 years like Methuselah and Noah?
- raducu 7y agoI was not talking from a religious perspective, I thought it was funny because I found the 70 year-good-life (health-wise) to be very accurate even in modern times; to me it seems the psalmist simply recorded what he saw around him (just like the Book of Ecclesiasticus is a very sobering/"uninspired" perspective of a "simple" man, very much unlike most of the bible). The religious explanation for the longer lives of early humans, I think it is that there were very few people and they needed the longer lifespans in order to reproduce more and somehow humanity became more degenerate down the line; also back then people could marry their sisters so I suppose there were very few recessive genes (guess that could also contribute to the longer lifespans) :) ? So perhaps the DNA could be somehow cleaned up and people could live 900 year life-spans ? Also, in a post messianic age, in the Old Testament it was written than people dying in their 120th year would be considered to die young (I vaguely remember reading that just because in the christian post-messianic age you wouldn't die at all)?
- Erlich_Bachman 7y agoOf all the good and useful things that religious texts are (and there are a lot), surely it would be a hard argument to sell that exact factual depictions of life was one of them. These texts are used as stories to pump up the spirit, teach connection, oneness, useful life skills and outlooks, but do you really think it was accurate descriptions of how life was? If so, why? What data have you seen to assume that when a religious text writes about someone who lived for 800 years - it is not just a poetic device? There is nothing we have seen in biology or evolutionary science that this was possible.
- harperlee 7y agoIt was quite surprising for me to read (in Angus Deaton’s The Great Escape - Nobel laureate) that most of the advances on living longer that we have achieved are basically focused on not dying young (baby, infant, adolescent); but that the overall limit has been fixed in its place since hundreds of years ago. Look at the shapes of this and to what do they converge: https://ourworldindata.org/uploads/2017/08/Survival-Curves-UK.png https://ourworldindata.org/uploads/2017/08/Survival-Curves-U... (That comes from this article by the way: https://ourworldindata.org/life-expectancy https://ourworldindata.org/life-expectancy) Im trying to find a chart of the evolution of age-specific mortality rate that very clearly shows that we have a mortality plateau up until about 30-35 years, and then the rate increases linearly. It is quite humbling. EDIT: This is the best I found: https://www.researchgate.net/profile/Gerardo_Chowell/publication/233908090/figure/fig8/AS:306540503420932@1450096359545/The-evolution-of-observed-age-specific-all-cause-mortality-rates-scaled-per-1000.png https://www.researchgate.net/profile/Gerardo_Chowell/publica... It is from Canada. The aforementioned book shows time series of several countries and periods, and helps driving the point home that (non-intentional) adult mortality has been more or less fixed since a long time ago.
- JaumeGreen 7y agoI read somewhere that those years could have just been lunar cicles, so 900 cicles would be about 75 years. Sorry, too long ago to remember the source, and if it has any backing.
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- Erlich_Bachman 7y agoIt is suprising how widespread this misconception is. ALL of (*ok maybe 99%) of "life extensionalists" or longevity enthusiasts are working on extending the useful lifespan, not just the technical heartbeat-covering lifespan. This is a given. What they mean by extending the total lifespan is that it is done using integral methods, improving the overall health of a human, meaning that it will increase total lifespan also, but since it is working on the general health, it will also by extension increase the useful lifespan, because the health at every point in life will increase, and points which were not useful (healthy) before interventions would become useful. This is not something longevity people just "forget", there is no crusade for a mathematical birth-to-death age increase, these people are not stupid.
- Nuzzerino 7y agoI was fortunate to meet him in 2007 at a local futurist meetup. I think you could say he is the epitome of "success through persistence". He's always been good at what he did, but if you go back 10, 20 years you wouldn't normally expect the level of success today to be reachable by his foundation, given how much negative skepticism there has always been around the research.
- nradov 7y agoBut he hasn't actually achieved any success yet. So the negative skepticism is warranted.
- maxander 7y agoWell, yes, in that no one has lived forever yet. :) But that he has established a substantial research foundation and normalized a subject that was virtually fringe science a few decades ago is tremendous success in itself.
- Nuzzerino 7y agoYeah, this is what I was referring to, thanks for clarifying!
- SmellyGeekBoy 7y agoI'm convinced at this point that most of the conditions and diseases we associated with "old age" are actually a result of lifestyle choices, or at least aggravated by them. Just eat a balanced diet, get regular exercise, and maintain a healthy weight and you'll be better off than the majority.
- melling 7y ago“science progresses one funeral at a time” Many people believe things that simply aren’t true and you can’t convince them otherwise. A new generation comes along and challenges entrenched ideas and progress is made. Perhaps we can grow past this way of thinking? What does the science say about your thoughts on the subject?
- antepodius 7y agoHow much of that effect comes about because people's brains stop being flexible due to age?
- Erlich_Bachman 7y agoThis is for the most part, incorrect. Please see this video of Aubrey de Grey, where he explains that those lifestyle choices you describe, while very helpful, can only increase your chances for your regular long life, and have a relatively small effect at that. They can sometimes have large effect on the negative side, where if we measure effect in people in poor conditions, where they have severely bad lifestyle choices, due to malnutrition or poisoning for example, or complete lack of vitamin sources, etc. Poor lifestyle can severely diminish base lifespan, but a good one cannot increase lifespan by a lot. If your genes are telling you to live to 70, you will not live to 100, no matter how many cabbages you eat or how many days spend hiking in the woods. To really increase lifespan beyond that we need actual new technology. There is no rational model in which the effect of good lifestyle choices would be an argument for not pursuing genetic and otherwise interventions to increase real lifespan. [1] https://www.codereactor.net/aubrey-de-grey-poor-nutrition-takes-a-big-toll-on-your-lifespan-but-excellent-nutrition-only-adds-small-benefit-compared-to-an-average-one/ https://www.codereactor.net/aubrey-de-grey-poor-nutrition-ta...
- melling 7y agoYes, we discussed a similar article a few weeks ago: https://news.ycombinator.com/item?id=20093668 https://news.ycombinator.com/item?id=20093668 For some reason, we converge on the same few observations, most of which have nothing to do with actually increasing the human lifespan.
- Nanocurrency 7y agoIs it me or these articles are getting more and more prevalent? That's good, I don't want Alzheimer, macular degeneration or other diseases of the old.
- gnode 7y agoI feel like gerontology is only tangentially related to the concept of immortality. No matter how biological life extension advances, you are still a highly vulnerable organism in a dangerous world. Something resembling actual immortality, in my mind, is a necessarily transhumanist field.
- cryofan 7y agowe are information....information can be created...information can be stored...information can be retrieved..man's ability to store and retrieve information increases as time goes on...therefore immortality can be achieved as long as a universe exists
- Theodores 7y ago150 pills a day would impose a lot on my gut, I can't imagine that this would extend my life. I am wondering if there is more to it than eating healthily, what about times of occasional fasting? Some of the real old timers did go through wartime rationing or worse. For years we had 100+ year old Japanese people taking the honours for oldest and always put that down to a diet of fish. But all of them lived through WW2 with the whole place firebombed into starvation. So they had a healthy diet plus this period where they must have had their bodies purge every bit of useless fat and strange mystery growth in their middle age. Other parts of the world have had the starvation or the healthy eating but not in the combination that happened in Japan. We generally have some exercise based regime to get rid of middle age spread. It does not work in most cases. So a spare tyre generally gets carried around for the rest of one's life, increasing the metabolic load and requiring more work from the vital organs. The radical option for getting rid of the spare tyre is to have the discipline of an athlete and to practically starve until the target weight is arrived at. In this deeper detox I am sure that one's relationship with bad foods can be reset too.
- DigitalTerminal 7y ago"(Is it possible the future will become a refuge for the rich, who experience life as a sequence of exquisite events and who might not understand the concept of entropy as relief or escape?)" Can physically and emotionally healthy people actually view death as a relief or escape? This idea seems completely insane to me. As an aside, people who want to die shouldn't/won't be forced to use longevity enhancing therapies to live longer, but I really think some psychological care should be considered for anyone refusing them.
- n4r9 7y agoI don't know about "relief" or "escape" but I'm comfortable with the idea of eventually having "had enough" of life. Kind of tangential: the human-style characters in Iain M Banks' fantastic and thoughtful Culture series of novels tend to come to this decision after a couple or a few hundred years. Some times they go into deep sleep to be awoken based on some external criteria (for example, when the war that they conduct with another ~~species~~ (edit: society) is proven to be morally justified).
- lmm 7y agoWhat today's fiction authors write, with no access to life extension technology, doesn't really tell us anything about what the reality would be like. It's very rare to find a healthy person - even in their '90s or '100s - who actually wants to die. Many more younger people imagine they would want to die at such an age. I suspect the same will be true for 200 or 400 year olds.
- n4r9 7y agoYou raise a very good point. I hadn't thought of looking up research on attitudes towards death in actual elderly people. It's an unusual one because I'm specifically thinking about people who might want to die simply because they've seen and gotten from life all that they want, not people who are fed up with the (present-day) privations of old age. I suspect you're right that only a very small proportion of today's elderly match this The closest thing I found after a little looking around is a recent initiative in the Netherlands called "Completed Life" - which seeks to extend the option of euthanasia to relatively healthy elderly people who have decided that their life is complete - and some associated research [0][1]. Lastly, on a slightly pedantic note, I think it's valid to invoke fictional worlds in response to someone who says that it's "insane" to feel a certain way. [0] http://www.elsvanwijngaarden.com/ http://www.elsvanwijngaarden.com/ [1] https://www.sciencedirect.com/science/article/pii/S0277953615002889 https://www.sciencedirect.com/science/article/pii/S027795361...
- Odenwaelder 7y agoThe problem with this approach is: You don't know if this lifestyle caused you reaching a certain age, there is no scientific basis whatsoever. Which turns it into a religion.
- tapland 7y agoYou can measure the group against the population in general to see if you have a significant change, if it only had an effect on people starting before age X, what the causes of death were (some could be omitted) etc, so I guess there is, we're just lacking data since it requires a lot more people doing this to get old first.
- tempodox 7y agoSo what? As long as the vendors of longevity products get rich everything is dandy. Getting and being rich is the only religion taken seriously anyway. Being an adept of the longevity religion requires you to be a high-level acolyte in the Church of Being Rich to begin with.
- blue_devil 7y agoAnd yet life expectancy in the US has been dropping steadily, at the longest sustained decline since 1915-1918 https://www.smithsonianmag.com/smart-news/us-life-expectancy-drops-third-year-row-reflecting-rising-drug-overdose-suicide-rates-180970942/ https://www.smithsonianmag.com/smart-news/us-life-expectancy...
- afthonos 7y agoIndeed. The problem of extending life has both scientific and social dimensions. We are currently working on the scientific aspect, but, in at least in the US, failing at the social one.
- amanaplanacanal 7y agoAs a society we don't treat mental health with the same urgency we treat physical health. As if they are two different things, and mental health is about our "choices", whereas physical health is just stuff that happens to us. It is at root very moralistic and judgemental.
- xvilka 7y agoThe only good way is to sponsor or crowdfund corresponding research. See SENS[1] foundation as a good example of such funding. [1] https://www.sens.org/ https://www.sens.org/
- rcar1046 7y agoThink how rich the early adopters will be when the wealth they’ve accumulated to afford life extension is able to compound for 100 years.
- winchling 7y agoIt seems inevitable. Repairing the natural damage that human bodies accumulate as they age will quickly become the cheapest way to treat and prevent heart disease and cancer in ordinary people. The small research community involved in life extension is a beacon of activity and optimism. The mega-rich are (or soon will be) lining up to fund it all both for profit and for their own personal life extention.
- unnouinceput 7y ago"You do not add years to your youth, you add years to your old age" - can't remember where I've read this but it struck me a lot. And worrying about your age when you'll die is not living your life to the fullest
- whatshisface 7y agoMost ways of preserving your health, for example not smoking, add years to your youth.
- tempodox 7y agoLiving Forever made easy: The more money you throw at me, the longer you'll live. Living literally forever requires a lifetime subscription, obviously.
- alpineidyll3 7y agoDeath is a an evolved feature of living systems, and will continue to be. These people are merely wasting what time they have on narcissism, and tragically misunderstand what life is about.