7 ms·
Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy (2018)
- audiometry 7y agoI think general strength-training folk-wisdom is that it's easier to build muscle if at some point in the past you had built muscle, even if it had withered in the meantime. I don't understand the science here, but I think they're saying the initial muscle-building efforts do something to the genome that allow future hypertrophy efforts to be more fruitful.
- AstralStorm 7y agoMind you, n=8 pilot study. The most interesting tidbit is related to aging, but they didn't check if old muscle responds similarly, or how the profiles are different in older individuals. Epigenetics is fascinating and can hold another key to fixing aging...
- baxtr 7y agoSmall n is not always a deal breaker, IF the small sample resembles the greater population (which I can't judge in this case). https://www.dailykos.com/stories/2008/11/9/656465/- https://www.dailykos.com/stories/2008/11/9/656465/-
- darawk 7y agoThat and if the effect size is sufficiently large, though I can't imagine n=8 is enough to detect an effect size of the type we're likely looking at here reliably.
- amval 7y agoSimplified and probably somehwat inaccurate explanation: The currently believed theory about this effect it's that the number of nuclei in your muscle cells increase, along with the actuall volume of the cell. Cell volume decreases quite fast, but the number of nuclei stays more or less constant, allowing you tor egain cell volume quite fast. Anabolic drugs push the natural upper limits of myonuclei per cell, which can remain higher than natural even years after stopping exercise/dosing. So once you have reached a certain level of hypertrophy
- lawlessone 7y agoour cells can have multiple nuclei?
- raverbashing 7y agoYup, muscle cells do Some have no nuclei, like (mature) red blood cells
- burfog 7y agoYes, in long muscle fibers and in the syncytiotrophoblast of the placenta. This involves repurposed viral DNA. Viruses use that DNA to spread directly from cell to cell. The placenta makes a giant multi-nucleated cell to block any gaps.
- rofo1 7y agoI've told several people the same thing, based on my experience and the experience of some friends of mine. I absolutely believe this is true. One thing that influence this is that the second (third, fourth) time that you are doing it, you are better at it and know exactly what to do. So, you get into shape faster. Also this: "Epidemiological studies in human ageing cohorts also suggest that low birth weight and gestational malnutrition are strongly associated with reduced skeletal muscle size, strength and gait speed in older age" More or less known among older folks.
- lamchob 7y agoDoes this mean, that the use of anabolic steroids to build muscle at one point in time can lead to better performance years after usage? For example, a young athlete uses it in his late teens/early twenties to gain muscle and then lays off the drug for a while. Then he returns to competitive sports, reaping the benefits of the formerly enhanced hypertrophy without any means to test against it?
- VoiceOfWisdom 7y agoCorrect, it does. Bodybuilders have known this for years.
- ddorian43 7y agoSame in fighting.
- throwawaymanbot 7y ago"Fighting" lol.
- sgt101 7y agoAnd rugby.
- rapsey 7y agoOr if the athlete was once male...
- lawlessone 7y agonever too late to educate yourself. https://www.menshealth.com/uk/fitness/a26798247/trans-athletes-sporting-performance/ https://www.menshealth.com/uk/fitness/a26798247/trans-athlet...
- rapsey 7y agoNot particularly educational and extremely one sided. The main source of information is by a gender identity doctor. One particular excerpt: > The connection between naturally occurring testosterone and athletic performance appears to be overstated. When researchers measured the T levels of elite athletes from 15 Olympic sports, more than 25 per cent of the men were below 10 nmol/L Yeah because training reduces testosterone.
- L_226 7y agoI have found this with myself - in uni ~7 years ago I was pretty into powerlifting (around 120kg squat, 120kg bench, 170kg deadlift at 184cm/81kg). Now as I go through on and off periods of training due to life etc. I find that it is relatively quick and easy for me to get back into decent shape. Like 2 weeks of training after even months of eating poorly and drinking too much is enough to get good muscle definition back and my strength goes back to probably 80% of my youthful peak. Obviously this is anecdata, YMMV.
- edejong 7y agoWell, n=2 (at least, HN?)
- yetihehe 7y agoI remember one bodybuilder/trainer said it's easy to lose weight. He dieted poorly, became fat, then was able to quickly reagin his good shape in a month, so he "proved" it's easy. This looks like he just proved that it's easy if you were already in good shape.
- anonoholic 7y agoFit to Fat and Back: https://www.youtube.com/watch?v=ew7g7AqGqzo https://www.youtube.com/watch?v=ew7g7AqGqzo
- nnq 7y ago...and the opposite curse applies to people who had fully couch-potato sedentary lifestyles in youth and want to work themselves into shape in their 30s ...it sucks :| Realizing that you might need to put 12+ months of continuous boring excruciating exercise to get what others can get with 1-2 moths of training only. Wish there was a pill to solve this for us (phisically-)lazy ones...
- taneq 7y agoYou're just doing the same work then as those others put in the first time around. Luckily only the first few weeks are boring and excruciating, then your body starts responding and it actually starts to feel good.
- mamon 7y agoChristian Bale dropping weight for a role in Machinist, only to gain the muscle back for the role in Batman [1] seems like a classic example of this effect. [1] https://www.menshealth.com/uk/fitness/lifestyle/a26004466/christian-bale-batman-vice-american-psycho-transformations/ https://www.menshealth.com/uk/fitness/lifestyle/a26004466/ch...
- barry-cotter 7y agoSteroids help enormously if you want to quickly put on large amounts of muscle.
- deleted 7y ago[deleted]
- _pmf_ 7y agoProliferation/increasing satellite cells is kind of the holy grail of body building. Creatine helps here a little (at least if you're deficient from a vegetarian/vegan diet): https://www.nrcresearchpress.com/doi/10.1139/h2001-045 https://www.nrcresearchpress.com/doi/10.1139/h2001-045 (aside from the "tactical" effects of creatine).
- mo1ok 7y agoDoes this scientifically explain the phenomenon colloquially known as "dad strength?"
- ericmcer 7y agoIs there such a thing as inheritance of epigenetics? I have done a lot of weight-lifting off and on and often wondered if I conceived a child while maintaining a perfect diet, tons of exercise and sleep, they would come out much differently than if they were conceived while i was eating garbage and laying around.