I am following this with interest. I have some variant of Marfan's syndrome but have not shown the associated heart problems. After consultation with a geneti

I am following this with interest. I have some variant of Marfan's syndrome but have not shown the associated heart problems. After consultation with a geneticist we concluded that I could spend a bunch of money to get the exact variant that I have of the relevant genes sequenced. But almost certainly I would learn that I have some variant of Marfan's syndrome that is not understood. Relatives who also have the same phenotype can get sequenced to verify that it is genetic. But since none of us are showing the most troublesome problems, and the literature almost certainly doesn't have our exact variation, I would learn nothing more than I know already. So just get an MRI every 5 years, and wait for costs to come down and research to improve. In 10-15 years look again and maybe the genetic test will be useful then. For a genetic condition as specific as mine, the sequencing done by these commercial providers is useless.