3 ms·
One alternative theory: Alzheimer as a metabolic disease. "We conclude that the term “type 3 diabetes” accurately reflects the fact that AD represents a form o
by fasteo 8y ago
One alternative theory: Alzheimer as a metabolic disease.
"We conclude that the term “type 3 diabetes” accurately reflects the fact that AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 diabetes mellitus and T2DM."
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/
- pjkundert 8y agoSignificant impact in 30 days. Without changing diet to reduce glucose. Can’t achieve 1mmol/L of Ketones in the blood, though, without a Ketogenic diet. The brain lights up in the PET scan on a Ketogenic diet: https://youtu.be/OU26epaihmw?t=1469 https://youtu.be/OU26epaihmw?t=1469
- mft_ 8y agoWasn't that PET scan showing ketone uptake? So it showed that brains can use ketones... but nothing about the activity or ability of the brain otherwise?
- copperx 8y agoYes. I have no idea what OP assumed by "the brain lights up."
- pjkundert 8y agoThe researcher claimed to have observed declining energy use for years before symptoms occurred, showing decreasing energy consumption leading to cell death regardless of fuel availability, finally leading to Alzheimer’s symptoms. Provision of ketones alone reversed this energy starvation. The PET scan literally lit up like a Christmas tree — turned from all blue/black to red! It was near the end of the presentation... If neural cellular degeneration is the target of any Alzheimer’s management strategy, wouldn’t dramatic energy consumption declines over decades before cell death, and reversal of these declines after a short treatment be of specific interest?