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Does anyone know how they ensure read order? Since it's a fluid that's moving around I'm having a hard time to grasp how they make sure they read the DNA in th
by KallDrexx 8y ago
Does anyone know how they ensure read order? Since it's a fluid that's moving around I'm having a hard time to grasp how they make sure they read the DNA in the same order it was written in.
- mbreese 8y agoYou wouldn’t. The read order would be encoded in the “file format”. Kind of like a Unicode byte order marker. You’d have to deconvolute the signal first, then computationally determine the strand you actually read.
- iso1337 8y agoRelated is querying: You can synthesize another pair of Oligos to selectively amplify part of the DNA that you wrote and only sequence that. Look up PCR if you are interested.
- shpongled 8y agoDNA polymerase "reads" in one direction, so you prime the polymerase with a short DNA sequence (a primer), that is complementary and located 5' (before) the section you want to read
- adjkant 8y agoWhen reading this it made me wonder if DNA storage will borrow a lot of concepts from SIMD