3 ms·

There are published human and animal Studies showing that piperine enhances serum concentration, extent of absorption and bioavailability of curcumin by 2,000%.

nradov 8y ago
Yes but is there any hard evidence that leads to improved health outcomes in humans?
- will_brown 8y ago
  What’s “hard evidence”? There are no shortage of published studies about the health benefits in humans. You might start with “Curcumin: A review of its effects on Human Health”. “Research suggests that curcumin can help in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, Anxiety, and hyperlipidemia.” The same study finds it may also help with exercise induced inflammation and muscle soreness, speeding up recovery in active people and a low dose can provide health benefits for people who have no diagnosed Heath conditions. Available at ncbi.nlm.nih.gov UCLA just published a study that curcumin improves memory and mood.
  - wdewind 8y ago
    I think what he's asking for is long term epidemiological studies, which are hard to come by. I'd have to see the studies you are referring to, but most likely they refer to measurements occurring over a relatively short time period, on a relatively small sample size (or in a lab on animals, or just cells, etc. etc.). This stuff is totally valid, but a lot of it is really hard to detect at a large scale level. You can justify many kinds of diets by looking at the short term biological impact of them, but the reality is that if these diets are so much better it shouldn't be so difficult to detect them in epidemiological studies. The classic example is the widely misinterpreted "China Study" which many people use to justify a vegetarian diet, but in fact did the opposite by proving that the effect size of eating red meat, while statistically significant, was literally 2 orders of magnitude below what would be considered clinically relevant at an epidemiological scale.
    - will_brown 8y ago
      Well I didn’t make a single claim as to the medical/health benefits of turmeric/curcumin anyway, not sure why he asked period. My point is about absorption, and curcumin is the perfect example of my point, by itself it isn’t bioavailable but studies provide “hard evidence” that black pepper makes curcumin 2000x more bioavailable.

nradov 8y ago

Yes but is there any hard evidence that leads to improved health outcomes in humans?

will_brown 8y ago
What’s “hard evidence”? There are no shortage of published studies about the health benefits in humans. You might start with “Curcumin: A review of its effects on Human Health”. “Research suggests that curcumin can help in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, Anxiety, and hyperlipidemia.” The same study finds it may also help with exercise induced inflammation and muscle soreness, speeding up recovery in active people and a low dose can provide health benefits for people who have no diagnosed Heath conditions. Available at ncbi.nlm.nih.gov UCLA just published a study that curcumin improves memory and mood.
- wdewind 8y ago
  I think what he's asking for is long term epidemiological studies, which are hard to come by. I'd have to see the studies you are referring to, but most likely they refer to measurements occurring over a relatively short time period, on a relatively small sample size (or in a lab on animals, or just cells, etc. etc.). This stuff is totally valid, but a lot of it is really hard to detect at a large scale level. You can justify many kinds of diets by looking at the short term biological impact of them, but the reality is that if these diets are so much better it shouldn't be so difficult to detect them in epidemiological studies. The classic example is the widely misinterpreted "China Study" which many people use to justify a vegetarian diet, but in fact did the opposite by proving that the effect size of eating red meat, while statistically significant, was literally 2 orders of magnitude below what would be considered clinically relevant at an epidemiological scale.
  - will_brown 8y ago
    Well I didn’t make a single claim as to the medical/health benefits of turmeric/curcumin anyway, not sure why he asked period. My point is about absorption, and curcumin is the perfect example of my point, by itself it isn’t bioavailable but studies provide “hard evidence” that black pepper makes curcumin 2000x more bioavailable.