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Central Dogma of Genetics May Not Apply to Cephalopods
- gus_massa 8y agoNice article, but the title is a small exaggeration. There are many known of the DNA -> RNA -> Protein rule. One of the most famous is the alteration of the Proline in the collagen. A big part of collagen is made of Proline, and another big part is made of Hydroxyproline (that is like proline, but one -H is replaced by a -OH). There is no code in the DNA for Hydroxyproline, you use the code for Proline and after the molecule is formed then you use a special enzyme to transform Proline into Hydroxyproline. https://en.wikipedia.org/wiki/Collagen#Amino_acids https://en.wikipedia.org/wiki/Collagen#Amino_acids Also, tRNA sometimes use weird bases, that are also not encoded directly in the DNA.
- dekhn 8y agothe central dogma (of molecular biology, not genetics) is more what you call a guideline, not a rule. It was also kind of meant humorously (Crick meant for it to be taken semi-seriously). And of course we've found many exceptions to the dogma over time. So, this is much less exciting an observation as you might think.