5 ms·
Biotech Company's Pig Vaccine Leads to New Alzheimer's Approach
- e40 8y agoCan't read with uBlock Origin default settings. Text is fuzzed.
- prophesi 8y agoHere's a clear, clutter-free version: http://outline.com/CXrVy9 http://outline.com/CXrVy9
- theandrewbailey 8y ago.blur-container { filter: blur(5px); } Who thought that was a good idea? Defeated by reader mode.
- eikenberry 8y agoI always forget about reader mode. I'll try to remember it more in the future. It let me read this site without having to worry about enabling javascript or dancing around ad-blocker issues.
- devereaux 8y ago> Although the small number of patients prevents United from drawing any major statistical conclusions A small number of patients only prevent drawing major statistical conclusion if the effect is too small compared to the size of the group.
- nonbel 8y ago>"The patients demonstrated improved brain function and showed a reduction in the protein plaque gumming up their neurons, the company’s report says." Still chasing the amyloid hypothesis I see. This is a symptom, not a cause, so they are wasting their time (in terms of actually helping the patients, eventually someone will randomly get "positive" results and a bunch of money if enough trials are run). 1) Up to 30% of cognitively normal elderly have detectable amyloid deposits: https://news.ycombinator.com/item?id=17444214#17453147 https://news.ycombinator.com/item?id=17444214#17453147 2) Only 70% of dementia patients have detectable amyloid deposits: https://news.ycombinator.com/item?id=17444214#17445337 https://news.ycombinator.com/item?id=17444214#17445337 3) Amyloid-related genetics can only account for < 10% of Alzheimer's cases: https://news.ycombinator.com/item?id=17444214#17457198 https://news.ycombinator.com/item?id=17444214#17457198 4) Amyloids are the most thermodynamically favorable structure that polypeptides can form (ie require constant vigilance by the cell to prevent): https://news.ycombinator.com/item?id=14914528#14917057 https://news.ycombinator.com/item?id=14914528#14917057 5) Can anyone find a disease state where they looked for amyloids and didn't find a positive correlation? I doubt it.
- fhood 8y agoAssuming what you say is true, HN continues its trend of having great content for software and related topic, and being next to useless for meaningful physics or medical news. I didn't notice this till my buddy who is a physicist pointed out that almost all of the physics articles on here are either wrong, or wildly misleading. It would be nice if we could be better about vetting this stuff as a community.
- nonbel 8y ago>"Assuming what you say is true" Don't take my word for it. Follow the links to what the primary literature says. >"being next to useless for meaningful physics or medical news" Well, to be fair the "amyloid hypothesis" is still the mainstream hypothesis. It's just that this is for reasons that are baffling to me. Afaict, it has nothing going for it at all vs the prior "cholinergic" hypothesis (which has resulted in treatments that actually appear to do something for the patient).
- SubiculumCode 8y agoAnyone have a link to the clinical trial?