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Ibuprofen induced liver toxiticy: https://livertox.nih.gov/Ibuprofen.htm https://livertox.nih.gov/Ibuprofen.htm "Rates of serum aminotransferase elevations du
by emersonrsantos 8y ago
Ibuprofen induced liver toxiticy:
https://livertox.nih.gov/Ibuprofen.htm https://livertox.nih.gov/Ibuprofen.htm
"Rates of serum aminotransferase elevations during low dose, chronic ibuprofen therapy are comparable to those that occur with placebo controls (0.4%). However, higher rates of ALT elevations occur with high, full doses of 2,400 to 3,200 mg daily (up to 16%)."
- tejasmanohar 8y agoThis is news to me. The more common side effect I've heard of from regular or excess NSAIDs like Ibuprofen are stomach problems (eg ulcers, gastritis, etc.).
- jjtheblunt 8y agoThat's a side-effect of inhibiting cyclooxygenase-1, which correlates to mucus production, such as that which protects stomach linings. Ibuprofen is a non-selective "COX"=cyclooxygenase inhibitor so inhibits COX-2, correlated with inflammation, while undesirably also inhibiting COX-1. This gives rise to the selective COX-2 inhibitors, meant to reduce inflammation with minimal mucus inhibition, such as Celebrex and Firocoxib.
- gregw2 8y agoSpeaking of liver toxicity, acetominophen/tylenol and alcohol can kill you. Not in the common case but if you are maxing out the acetaminophen for a prolonged period and drink and stop drinking, you should get educated on the dynamics and side effects. I was shocked to only find out about this midlife when my wife was on painkillers post surgery for an extended period and was using both painkillers and alcohol to self medicate. And her doc noticed some concerning liver results which later turned out fine. Be careful out there!
- sannee 8y ago> high, full doses of 2,400 to 3,200 mg daily Holy shit that's a lot of ibuprofen. If you are taking that much every day, you definitely have some more pressing concern than liver toxicity...