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I personally think that machine learning will have a broad effect on the legitimacy of the pharmaceutical industries and health care in general. Once real data
by corporateguy6 8y ago
I personally think that machine learning will have a broad effect on the legitimacy of the pharmaceutical industries and health care in general. Once real data about all of these drugs, treatments, and expensive procedures finally starts being collected and exposed, the public will see things as they are, a farce.
- viraptor 8y ago> real data about ... collected and exposed Which is not a machine learning issue. Just collecting the information is a costly / time consuming issue which can't be outsourced to servers.
- corporateguy6 8y agoRight but the current innovation with regards to ml for medicine will force more data to be collected.
- dnautics 8y agoThe amount of data you would require to do proper machine learning using current gradient descent techniques are orders of magnitude greater than that done in a drug study.
- viraptor 8y agoWe have lots of ways to process and learn from data already. ML may make some things easier, but we're ready to learn more things right now with existing tools. Getting the data is the problem.
- sanxiyn 8y agoFor drugs, we already do postmarketing surveillance. Whatever you think of pharmas, drugs are not a farce.
- corporateguy6 8y agoSure, plenty are. Antidepressants for one. It’s a complex topic, and they have their place, but most are ineffective and dangerous
- mrunkel 8y agoI'll just leave this here. https://rationalwiki.org/wiki/Extraordinary_claims_require_extraordinary_evidence https://rationalwiki.org/wiki/Extraordinary_claims_require_e...
- deleted 8y ago[deleted]
- thwy12321 8y agoThere's scores of evidence and studies about this. Don't feel like looking all of them up. https://www.webmd.com/mental-health/news/20080227/antidepressants-no-better-than-placebo#1 https://www.webmd.com/mental-health/news/20080227/antidepres...
- eesmith 8y agoAnd yet there's https://www.sciencedirect.com/science/article/pii/S0140673617328027 https://www.sciencedirect.com/science/article/pii/S014067361... from 2018 (a decade later) which concludes "All antidepressants were more efficacious than placebo in adults with major depressive disorder. Smaller differences between active drugs were found when placebo-controlled trials were included in the analysis, whereas there was more variability in efficacy and acceptability in head-to-head trials." Along with commentaries like https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/benefits-of-antidepressants-news-or-fake-news/687A4E815C8AB2E1CEE1020BF6E8CEBC/core-reader https://www.cambridge.org/core/journals/the-british-journal-... where the abstract is: > Although antidepressant drugs are commonly effective, several meta-analyses of antidepressant drug trials undertaken decades after their introduction suggested that they were effectively acting as placebos. A recent meta-analysis concluded that they were effective. Both conclusions have been widely taken up by the media. This paper seeks to explain the disconnect.
- jcranmer 8y agoIf the pharmaceutical industry were willing to fake efficacy results, surely they could do better than having over ½ their drugs fail Phase III efficacy trials. Especially since one thing everyone agrees on is that the best way to lower drug costs is to figure out which drugs are going to fail Phase III much, much earlier.
- thwy12321 8y agohttps://www.webmd.com/mental-health/news/20080227/antidepressants-no-better-than-placebo#1 https://www.webmd.com/mental-health/news/20080227/antidepres...