6 ms·

FYI, 23andme provides an Late-Onset Alzheimer's Disease report[1] based via the ε4 variant but does not test for a person's full APOE genotype. [1] https://you

FYI, 23andme provides an Late-Onset Alzheimer's Disease report[1] based via the ε4 variant but does not test for a person's full APOE genotype. [1] https://you.23andme.com/reports/ghr.alzheimers/ https://you.23andme.com/reports/ghr.alzheimers/

subcosmos 8y ago
pssst .... APOE genotype predicts how much viral DNA for Herpes is found in the brain .... post mortem ..... It's almost as if Herpes viruses transport around the body the same way ;) (Bar plots in this paper are LOG!) https://jvi.asm.org/content/80/11/5383/figures-only https://jvi.asm.org/content/80/11/5383/figures-only
- Scaevolus 8y ago
  There's a theory that amyloid-beta plaques are protective reactions to encapsulate infections, which go out of control in Alzheimer's. As people age, the blood-brain barrier weakens, allowing more viral particles in. This is why people with herpes are at higher risk. https://www.sciencedaily.com/releases/2018/07/180705143920.htm https://www.sciencedaily.com/releases/2018/07/180705143920.h...
  - lotsofpulp 8y ago
    I thought almost everyone had some type of herpes simplex (chicken pox, cold sores, warts, etc). Does that mean almost everyone is at higher risk?
copperx 8y ago
Now I'm scared; 23andme reported that I'm at risk for Late-Onset Alzheimer's. What lifestyle changes can I make to reduce the risk of liver cancer?
- subcosmos 8y ago
  Im a Phd, not an MD, but I'm currently trying to get my MD to see the light : https://www.sciencedaily.com/releases/2018/07/180712100515.htm https://www.sciencedaily.com/releases/2018/07/180712100515.h...
- rfinney 8y ago
  Vigorous exercise may help with Alzheimer's. https://www.health.harvard.edu/mind-and-mood/vigorous-exercise-may-counter-cognitive-decline-in-early-alzheimers https://www.health.harvard.edu/mind-and-mood/vigorous-exerci... The results indicate that aerobic exercise is more effective than any currently approved medication in fore-stalling Alzheimer's disease. Also , keep your weight down. https://www.endocrineweb.com/news/obesity/55627-being-overweight-increases-risk-liver-cancer https://www.endocrineweb.com/news/obesity/55627-being-overwe... A new study found a culprit for the increasing rates of liver cancer: obesity. The study published in the journal, Cancer Research, found that high body mass index (BMI) and a large waist circumference were associated with an increased risk for liver cancer. In addition, having type 2 diabetes, another result of obesity, also increases the risk.
  - ekianjo 8y ago
    Keeping weight down reduces risks across the spectrum, probably linked to the immune system. So nothing specific to Alzheimer.
- bohm 8y ago
  take a daily herpes antiviral https://www.healthline.com/health-news/evidence-of-link-between-herpes-and-dementia https://www.healthline.com/health-news/evidence-of-link-betw... and reduce your alzheimer's risk by 90%
  - mirimir 8y ago
    Hey, I've been taking acyclovir for decades. Maybe I'll luck out. But at least, I avoid the excruciating sores.
    - copperx 8y ago
      Are you taking acyclovir solely for Alzheimer's prevention?
  - deleted 8y ago
    [deleted]
  - dd36 8y ago
    https://bottomlineinc.com/health/alzheimers/warning-a-cold-sore-could-cause-alzheimers https://bottomlineinc.com/health/alzheimers/warning-a-cold-s... A family member has herpes and recently started showing signs of dementia. I’m going to have them try that regimen. I’m also going to reach out to that doctor.
  - tim333 8y ago
    See also https://news.ycombinator.com/item?id=17540094 https://news.ycombinator.com/item?id=17540094 on the same stuff
- lwf 8y ago
  Their FAQ actually provides all the pointers I was otherwise able to come up with, so is probably worth a shot: https://you.23andme.com/reports/ghr.alzheimers/faq/ https://you.23andme.com/reports/ghr.alzheimers/faq/ In addition, you may find it helpful to talk to a genetic counselor about your results; your GP/PCP should be able to get that sorted, although 23andme provides additional resources. https://you.23andme.com/tools/genetic-counseling/ https://you.23andme.com/tools/genetic-counseling/
- foxyv 8y ago
  Intermittent fasting is showing promising results. Also probably the best bet for preventing diabetes and obesity.

subcosmos 8y ago

pssst .... APOE genotype predicts how much viral DNA for Herpes is found in the brain .... post mortem ..... It's almost as if Herpes viruses transport around the body the same way ;) (Bar plots in this paper are LOG!) https://jvi.asm.org/content/80/11/5383/figures-only https://jvi.asm.org/content/80/11/5383/figures-only

Scaevolus 8y ago
There's a theory that amyloid-beta plaques are protective reactions to encapsulate infections, which go out of control in Alzheimer's. As people age, the blood-brain barrier weakens, allowing more viral particles in. This is why people with herpes are at higher risk. https://www.sciencedaily.com/releases/2018/07/180705143920.htm https://www.sciencedaily.com/releases/2018/07/180705143920.h...
- lotsofpulp 8y ago
  I thought almost everyone had some type of herpes simplex (chicken pox, cold sores, warts, etc). Does that mean almost everyone is at higher risk?

copperx 8y ago

Now I'm scared; 23andme reported that I'm at risk for Late-Onset Alzheimer's. What lifestyle changes can I make to reduce the risk of liver cancer?

subcosmos 8y ago
Im a Phd, not an MD, but I'm currently trying to get my MD to see the light : https://www.sciencedaily.com/releases/2018/07/180712100515.htm https://www.sciencedaily.com/releases/2018/07/180712100515.h...
rfinney 8y ago
Vigorous exercise may help with Alzheimer's. https://www.health.harvard.edu/mind-and-mood/vigorous-exercise-may-counter-cognitive-decline-in-early-alzheimers https://www.health.harvard.edu/mind-and-mood/vigorous-exerci... The results indicate that aerobic exercise is more effective than any currently approved medication in fore-stalling Alzheimer's disease. Also , keep your weight down. https://www.endocrineweb.com/news/obesity/55627-being-overweight-increases-risk-liver-cancer https://www.endocrineweb.com/news/obesity/55627-being-overwe... A new study found a culprit for the increasing rates of liver cancer: obesity. The study published in the journal, Cancer Research, found that high body mass index (BMI) and a large waist circumference were associated with an increased risk for liver cancer. In addition, having type 2 diabetes, another result of obesity, also increases the risk.
- ekianjo 8y ago
  Keeping weight down reduces risks across the spectrum, probably linked to the immune system. So nothing specific to Alzheimer.
bohm 8y ago
take a daily herpes antiviral https://www.healthline.com/health-news/evidence-of-link-between-herpes-and-dementia https://www.healthline.com/health-news/evidence-of-link-betw... and reduce your alzheimer's risk by 90%
- mirimir 8y ago
  Hey, I've been taking acyclovir for decades. Maybe I'll luck out. But at least, I avoid the excruciating sores.
  - copperx 8y ago
    Are you taking acyclovir solely for Alzheimer's prevention?
- deleted 8y ago
  [deleted]
- dd36 8y ago
  https://bottomlineinc.com/health/alzheimers/warning-a-cold-sore-could-cause-alzheimers https://bottomlineinc.com/health/alzheimers/warning-a-cold-s... A family member has herpes and recently started showing signs of dementia. I’m going to have them try that regimen. I’m also going to reach out to that doctor.
- tim333 8y ago
  See also https://news.ycombinator.com/item?id=17540094 https://news.ycombinator.com/item?id=17540094 on the same stuff
lwf 8y ago
Their FAQ actually provides all the pointers I was otherwise able to come up with, so is probably worth a shot: https://you.23andme.com/reports/ghr.alzheimers/faq/ https://you.23andme.com/reports/ghr.alzheimers/faq/ In addition, you may find it helpful to talk to a genetic counselor about your results; your GP/PCP should be able to get that sorted, although 23andme provides additional resources. https://you.23andme.com/tools/genetic-counseling/ https://you.23andme.com/tools/genetic-counseling/
foxyv 8y ago
Intermittent fasting is showing promising results. Also probably the best bet for preventing diabetes and obesity.