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I highly recommend uploading your 23andme data to Promethease, which dramatically increases the amount of research matched to your genome and provides a better

I highly recommend uploading your 23andme data to Promethease, which dramatically increases the amount of research matched to your genome and provides a better interface: https://promethease.com/ https://promethease.com/ I discovered that I have one copy of the Delta 32 mutation. Two copies provides nearly complete immunity to AIDs, but being lucky enough to have just one copy means that it will take significantly longer to get AIDS should I ever get HIV. Knowing that I'm resistant to noroviruses also makes me more comfortable about traveling. I discovered I have a 7x risk of going bald, which wasn't exciting. Beyond this, results have been too contradictory to make use of. Genetics are interesting, but our behavior has a much greater impact on our lives.

RivieraKid 8y ago
Promethease has a really bad and confusing interface in my opinion... 23andme is much better designed.
- afturner 8y ago
  when did you last use it? I found it to be quite usable imho a few weeks ago
wild_preference 8y ago
> Knowing that I'm resistant to noroviruses also makes me more comfortable about traveling. This seems like one of the major downsides of these services. I think you would've been better off in life if you, say, did the traveling you wanted to do instead of let some genetic markers drive your apprehensions.
searine 8y ago
Word of warning. Take promethease with a grain of salt. For example, promethease predicted a deletion in my genome (didn't actually observe a call, just inferred the deletion from linked sites) for a highly pathogenic disease in my data. However upon further inspection of the loci (I've done deep deep sequencing of my genome) it was a false positive. Promethease is very very useful, but it shows you all the data including some of the more hairy sites. It is a great starting place but if you find a deleterious variant that may impact your health, follow up with your health care provider.
- elektor 8y ago
  You mention a "deep sequencing" of your genome,, what does that look like?
  - searine 8y ago
    Just stupidly high coverage. Something like 200x coverage over six replicates from blood and saliva. We needed DNA for QA purposes and I happen to have DNA, dontchaknow.

RivieraKid 8y ago

Promethease has a really bad and confusing interface in my opinion... 23andme is much better designed.

afturner 8y ago
when did you last use it? I found it to be quite usable imho a few weeks ago

wild_preference 8y ago

> Knowing that I'm resistant to noroviruses also makes me more comfortable about traveling. This seems like one of the major downsides of these services. I think you would've been better off in life if you, say, did the traveling you wanted to do instead of let some genetic markers drive your apprehensions.

searine 8y ago

Word of warning. Take promethease with a grain of salt. For example, promethease predicted a deletion in my genome (didn't actually observe a call, just inferred the deletion from linked sites) for a highly pathogenic disease in my data. However upon further inspection of the loci (I've done deep deep sequencing of my genome) it was a false positive. Promethease is very very useful, but it shows you all the data including some of the more hairy sites. It is a great starting place but if you find a deleterious variant that may impact your health, follow up with your health care provider.

elektor 8y ago
You mention a "deep sequencing" of your genome,, what does that look like?
- searine 8y ago
  Just stupidly high coverage. Something like 200x coverage over six replicates from blood and saliva. We needed DNA for QA purposes and I happen to have DNA, dontchaknow.