Dislike the title. Not like there hasn't been other "real progress" in Parkinson's elsewhere. Yes, there is a burgeoning gut-brain line of thought in PD but i

Dislike the title. Not like there hasn't been other "real progress" in Parkinson's elsewhere. Yes, there is a burgeoning gut-brain line of thought in PD but it's not the only thing. Furthermore, the study that is referred is a retrospective case-control study - yes this picks out signals in historical records, but this would be considered a preliminary statistical sign that a prospective, randomized trial would have to try and replicate. https://www.ncbi.nlm.nih.gov/pubmed/?term=0+RESEARCH+ARTICLEPARKINSON’S+DISEASE+The+vermiform+appendix+impacts+the+risk+of+developing+Parkinson’s+disease https://www.ncbi.nlm.nih.gov/pubmed/?term=0+RESEARCH+ARTICLE... Additionally, I would characterize this as one of many things to be excited about in the PD research / clinical world today: For example - things that would be useful to patients - characterization of GBA mutations and new therapeutic compounds in the pipeline. Same with LRRK2. For more in the gut-brain line of thinking - the use of GLP agonists medicines - first shown to be protective of islet cells in the pancreas in diabetes, in a human randomized control trial that showed decreased decline in Parkinson's disease vs. placebo controls. All of these are something other than a "Me too" dopamine drug. Plus RT-QuiC techniques for an actual blood test for Parkinson's.... I don't have to mention deep brain stimulation (DBS), which has been around for 3-4 decades, but the newer devices and techniques have an effect size in blinded trials that equal or exceed the effect size of previous trials that were open label...