The associated paper to the article is: https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2005086&type=printable https://journals.plos

The associated paper to the article is: https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2005086&type=printable https://journals.plos.org/plosbiology/article/file?id=10.137... p.15 has a summary of what they propose, e.g., density of p21+ chondrocytes, as an inhibitor: "Because we found that the extent of compensatory proliferation does not linearly correlate with cell density—but it does with the proportion of p21+ chondrocytes — we posit that density plays a permissive rather than an instructive role and that stress signals emanating from p21+ chondrocytes are needed as well."