For anyone wondering about what's wrong with mouse testing, here is a funny but informative video on the subject[1]. One highlight: >After a drug is confirmed

For anyone wondering about what's wrong with mouse testing, here is a funny but informative video on the subject[1]. One highlight: >After a drug is confirmed as safe and efficacious in preclinical studies, it is tested in healthy human volunteers for first in man trials. In 2006, a phase I clinical study was conducted for a CD28 superagonist antibody TGN1412 in six human volunteers. After very first infusion of a dose 500 times smaller than that found safe in animal studies, all six human volunteers faced life-threatening conditions involving multiorgan failure for which they were moved to intensive care unit Source[2]. [1] https://www.youtube.com/watch?v=zvJHq2FJPDM https://www.youtube.com/watch?v=zvJHq2FJPDM [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964774/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964774/