3 ms·
But is it really? Elevated blood glucose, as in Type 2 Diabetes, has LONG been known to be primarily driven by excessive production of glucose by the liver due
by subcosmos 8y ago
But is it really?
Elevated blood glucose, as in Type 2 Diabetes, has LONG been known to be primarily driven by excessive production of glucose by the liver due to liver insulin resistance. In fact, the way that the drug metformin improves diabetes is by shutting that pathway down.
http://diabetes.diabetesjournals.org/content/50/8/1807.short http://diabetes.diabetesjournals.org/content/50/8/1807.short
Thats not dietary, thats the hormone insulin being ignored by the liver. This is further complicated by the fact that peripheral tissues, like muscle, are themselves insulin resistant.
The TCF7L2 pathway has been shown to be down-regulated in all of these tissues in diabetics.
- timr 8y agoTCF7L2 is a transcription factor. It is involved in many pathways in human biology, of which diabetes is one. Observing that it is downregulated in diabetics provides no evidence for or against any theories concerning BPA.
- subcosmos 8y agoIt's also the most statistically significant gene, in the whole dang genome, associated with Type 2 Diabetes. And out of a compound library of 20k chemicals, BPA had the top effect on it. Seems significant to me Also worth noting that BPA has been shown to specifically effect the occupancy of TCF7L2 at transcription factor binding sites in Chip-Seq experiments. http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2015.ED.1.FRI-299 http://press.endocrine.org/doi/abs/10.1210/endo-meetings.201... Lastly, before calling someone else's claims psuedoscientific, you may want to do some homework and check your previous biases. We could certainly use someone with your skills to help model BPAs interaction with the Androgen receptor. Might just save millions of lives....
- deleted 8y ago[deleted]
- deleted 8y ago[deleted]