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There are literally hundreds of papers on BPA and its links with diabetes. The only difference now is that we have the molecular culprit behind the trend. http

There are literally hundreds of papers on BPA and its links with diabetes. The only difference now is that we have the molecular culprit behind the trend. https://www.ucsusa.org/our-work/center-science-and-democracy/promoting-scientific-integrity/bisphenol-a.html https://www.ucsusa.org/our-work/center-science-and-democracy...

timr 8y ago
"There are literally hundreds of papers on BPA and its links with diabetes." There are literally not. The review you've linked to cites a handful of papers involving minor effects observed in mouse studies. Moreover, the paper you originally cited proves nothing even approximating a mechanism. I'm not suggesting anything about the safety of BPA, but it's utter nonsense to claim that it is a more plausible explanation for the diabetes epidemic than sugar consumption. A few mouse studies do not change 50+ years of established science on the relationship between sugar and diabetes.
- subcosmos 8y ago
  But is it really? Elevated blood glucose, as in Type 2 Diabetes, has LONG been known to be primarily driven by excessive production of glucose by the liver due to liver insulin resistance. In fact, the way that the drug metformin improves diabetes is by shutting that pathway down. http://diabetes.diabetesjournals.org/content/50/8/1807.short http://diabetes.diabetesjournals.org/content/50/8/1807.short Thats not dietary, thats the hormone insulin being ignored by the liver. This is further complicated by the fact that peripheral tissues, like muscle, are themselves insulin resistant. The TCF7L2 pathway has been shown to be down-regulated in all of these tissues in diabetics.
  - timr 8y ago
    TCF7L2 is a transcription factor. It is involved in many pathways in human biology, of which diabetes is one. Observing that it is downregulated in diabetics provides no evidence for or against any theories concerning BPA.
    - subcosmos 8y ago
      It's also the most statistically significant gene, in the whole dang genome, associated with Type 2 Diabetes. And out of a compound library of 20k chemicals, BPA had the top effect on it. Seems significant to me Also worth noting that BPA has been shown to specifically effect the occupancy of TCF7L2 at transcription factor binding sites in Chip-Seq experiments. http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2015.ED.1.FRI-299 http://press.endocrine.org/doi/abs/10.1210/endo-meetings.201... Lastly, before calling someone else's claims psuedoscientific, you may want to do some homework and check your previous biases. We could certainly use someone with your skills to help model BPAs interaction with the Androgen receptor. Might just save millions of lives....
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- subcosmos 8y ago
  No, there literally are hundreds. Look at the graph in pubmed. https://www.ncbi.nlm.nih.gov/pubmed/?term=bisphenol+a https://www.ncbi.nlm.nih.gov/pubmed/?term=bisphenol+a Forgive me, but I don't have time for this.
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timr 8y ago

"There are literally hundreds of papers on BPA and its links with diabetes." There are literally not. The review you've linked to cites a handful of papers involving minor effects observed in mouse studies. Moreover, the paper you originally cited proves nothing even approximating a mechanism. I'm not suggesting anything about the safety of BPA, but it's utter nonsense to claim that it is a more plausible explanation for the diabetes epidemic than sugar consumption. A few mouse studies do not change 50+ years of established science on the relationship between sugar and diabetes.

subcosmos 8y ago
But is it really? Elevated blood glucose, as in Type 2 Diabetes, has LONG been known to be primarily driven by excessive production of glucose by the liver due to liver insulin resistance. In fact, the way that the drug metformin improves diabetes is by shutting that pathway down. http://diabetes.diabetesjournals.org/content/50/8/1807.short http://diabetes.diabetesjournals.org/content/50/8/1807.short Thats not dietary, thats the hormone insulin being ignored by the liver. This is further complicated by the fact that peripheral tissues, like muscle, are themselves insulin resistant. The TCF7L2 pathway has been shown to be down-regulated in all of these tissues in diabetics.
- timr 8y ago
  TCF7L2 is a transcription factor. It is involved in many pathways in human biology, of which diabetes is one. Observing that it is downregulated in diabetics provides no evidence for or against any theories concerning BPA.
  - subcosmos 8y ago
    It's also the most statistically significant gene, in the whole dang genome, associated with Type 2 Diabetes. And out of a compound library of 20k chemicals, BPA had the top effect on it. Seems significant to me Also worth noting that BPA has been shown to specifically effect the occupancy of TCF7L2 at transcription factor binding sites in Chip-Seq experiments. http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2015.ED.1.FRI-299 http://press.endocrine.org/doi/abs/10.1210/endo-meetings.201... Lastly, before calling someone else's claims psuedoscientific, you may want to do some homework and check your previous biases. We could certainly use someone with your skills to help model BPAs interaction with the Androgen receptor. Might just save millions of lives....
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subcosmos 8y ago
No, there literally are hundreds. Look at the graph in pubmed. https://www.ncbi.nlm.nih.gov/pubmed/?term=bisphenol+a https://www.ncbi.nlm.nih.gov/pubmed/?term=bisphenol+a Forgive me, but I don't have time for this.

deleted 8y ago

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