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Rewritten for normal people: Cancer sometimes becomes resistant to chemotherapy, but we did a study that shows a certain type of lung cancer is highly dependen

Rewritten for normal people: Cancer sometimes becomes resistant to chemotherapy, but we did a study that shows a certain type of lung cancer is highly dependent on a certain amino acid and when you fast intermittently it deprives the cancer of that amino acid and causes the cancer cells to die.

atrexler 8y ago
Well, to be precise- this study shows no evidence of a fasting effect. they show if you starve cells in a dish in a way that might mimic what happens when you fast, you can kill the cells. I didn't see any mention of even mouse studies in there, so I don't know what their in vivo model was but it mostly looks like cell culture to me (apologies if I've missed that). Extrapolating that to humans is extremely hard. For sure a promising result but its pretty preliminary.
- randcraw 8y ago
  The Guidi and Longo paper isn't a study at all. They're summarizing the work of Obrist et al, 2018: https://www.ncbi.nlm.nih.gov/pubmed/29875130 https://www.ncbi.nlm.nih.gov/pubmed/29875130 Apparently efforts similar to these go back to at least six years. "Metabolic reprogramming: A new paradigm for targeting cisplatin resistant cells" describes a recurring research program that began in 2012 which seeks to impede cancer via restraining oxidative metabolism, though I think their method of blocking cancer cell metabolism may be more selective than starving ALL of the patient's cells. http://grantome.com/grant/NIH/IK2-BX001289-03 http://grantome.com/grant/NIH/IK2-BX001289-03
varunpant 8y ago
Fast for how long ? Few days a week ?
- atrexler 8y ago
  I've no idea about the fasting stuff. Just thought its important to make clear this particular study is all about doing stuff to cells or lumps of cells in dishes (again sorry if I missed more involved model system in the paper). Whether thats a good model for cancer in people and how fasting interacts with that I honestly have no idea.
- aviv 8y ago
  Prolonged water fasting of 14 to 40 days or dry fasting (no water, no food) for 4 to 10 days will rid your body of many "diseases" the modern medical world wants you to believe are either incurable or only treatable by whatever patented treatment they can sell you. Fasting is the enemy of Big Pharma and anyone else profiting monetarily in the modern medicine money machine, including doctors who will do all they can before they admit a simple fast fixes stuff they spent 10 years in school studying. Preventing fasting from entering the mainstream is criminal, but more and more people are slowly becoming aware and seeing the results.
  - menacingly 8y ago
    You may be correct in this instance, but I've come to be just as suspicious of folks claiming their healing approach is held back by big pharma as I am of big pharma itself
    - aviv 8y ago
      As you should be, so do your own research, hopefully before a disease shows up and the forces around you (doctors, friends, family) push you towards mainstream treatment options that at best will put you on a lifelong symptom prevention regime instead of actually fixing the underlying cause of whatever "disease" they say you have. Modern medicine invented thousands of names diseases, when all it is is your body becoming acidic and manifesting this terrible state in any sensitive part of your body, hence the naming of diseases begins. It's like cancer. There are no a hundred different types of cancer. That's marketing. Just like 10 types of Macbooks.
      - etatoby 8y ago
        Unfortunately the app I'm using to browse HN does not provide a Vote down button. Are you serious? Do you seriously believe that in an organism as complex as us, all the infinite ways it can fail boil down to a single catchphrase? Do you even know what the scientific method is?
        8y ago
pandasun 8y ago
> Rewritten for normal people Thank you =)

atrexler 8y ago

Well, to be precise- this study shows no evidence of a fasting effect. they show if you starve cells in a dish in a way that might mimic what happens when you fast, you can kill the cells. I didn't see any mention of even mouse studies in there, so I don't know what their in vivo model was but it mostly looks like cell culture to me (apologies if I've missed that). Extrapolating that to humans is extremely hard. For sure a promising result but its pretty preliminary.

randcraw 8y ago
The Guidi and Longo paper isn't a study at all. They're summarizing the work of Obrist et al, 2018: https://www.ncbi.nlm.nih.gov/pubmed/29875130 https://www.ncbi.nlm.nih.gov/pubmed/29875130 Apparently efforts similar to these go back to at least six years. "Metabolic reprogramming: A new paradigm for targeting cisplatin resistant cells" describes a recurring research program that began in 2012 which seeks to impede cancer via restraining oxidative metabolism, though I think their method of blocking cancer cell metabolism may be more selective than starving ALL of the patient's cells. http://grantome.com/grant/NIH/IK2-BX001289-03 http://grantome.com/grant/NIH/IK2-BX001289-03

varunpant 8y ago

Fast for how long ? Few days a week ?

atrexler 8y ago
I've no idea about the fasting stuff. Just thought its important to make clear this particular study is all about doing stuff to cells or lumps of cells in dishes (again sorry if I missed more involved model system in the paper). Whether thats a good model for cancer in people and how fasting interacts with that I honestly have no idea.
aviv 8y ago
Prolonged water fasting of 14 to 40 days or dry fasting (no water, no food) for 4 to 10 days will rid your body of many "diseases" the modern medical world wants you to believe are either incurable or only treatable by whatever patented treatment they can sell you. Fasting is the enemy of Big Pharma and anyone else profiting monetarily in the modern medicine money machine, including doctors who will do all they can before they admit a simple fast fixes stuff they spent 10 years in school studying. Preventing fasting from entering the mainstream is criminal, but more and more people are slowly becoming aware and seeing the results.
- menacingly 8y ago
  You may be correct in this instance, but I've come to be just as suspicious of folks claiming their healing approach is held back by big pharma as I am of big pharma itself
  - aviv 8y ago
    As you should be, so do your own research, hopefully before a disease shows up and the forces around you (doctors, friends, family) push you towards mainstream treatment options that at best will put you on a lifelong symptom prevention regime instead of actually fixing the underlying cause of whatever "disease" they say you have. Modern medicine invented thousands of names diseases, when all it is is your body becoming acidic and manifesting this terrible state in any sensitive part of your body, hence the naming of diseases begins. It's like cancer. There are no a hundred different types of cancer. That's marketing. Just like 10 types of Macbooks.
    - etatoby 8y ago
      Unfortunately the app I'm using to browse HN does not provide a Vote down button. Are you serious? Do you seriously believe that in an organism as complex as us, all the infinite ways it can fail boil down to a single catchphrase? Do you even know what the scientific method is?
      - 8y ago

pandasun 8y ago

> Rewritten for normal people Thank you =)